Tracing the origins of centrioles, cilia, and flagella

Carvalho-Santos, Zita; Azimzadeh, Juliette; Pereira-Leal, José B.; Bettencourt-Dias, Mónica

doi:10.1083/jcb.201011152

Cited by 344 publications

(294 citation statements)

References 129 publications

(202 reference statements)

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“…Even with respect to the centriole there is debate as to whether it perhaps evolved from a single triplet blade (Marshall 2009). However, recent bioinformatics interrogation of genome sequences suggests the structural complexity of the centriole is defined by only a handful of conserved proteins (Carvalho-Santos et al 2011). Central to the definition of ninefold triplet microtubule symmetry is SAS-6, a conserved protein present at the proximal end of centrioles (figure 3).…”

Section: Origin Of Nine-fold Symmetrymentioning

confidence: 99%

Eukaryotic Flagella: Variations in Form, Function, and Composition during Evolution

2014

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Section: Origin Of Nine-fold Symmetrymentioning

confidence: 99%

Eukaryotic Flagella: Variations in Form, Function, and Composition during Evolution

2014

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“…Cilia and the basal bodies that give rise to their axonemal structure are ubiquitously distributed across major eukaryotic groups, with the exception of flowering plants, most fungi and amoebae (Johnson and Leroux, 2010;Carvalho-Santos et al, 2011). Although the membrane surrounding the microtubule-based axonemal core is continuous with the plasma membrane, the ciliary lipidome and proteome are distinct (Nachury et al, 2010;Hsiao et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Early eukaryotic origins for cilia-associated bioactive peptide-amidating activity

Kumar

Blaby‐Haas

Merchant

et al. 2016

Journal of Cell Science

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Ciliary axonemes and basal bodies were present in the last eukaryotic common ancestor and play crucial roles in sensing and responding to environmental cues. Peptidergic signaling, generally considered a metazoan innovation, is essential for organismal development and homeostasis. Peptidylglycine α-amidating monooxygenase (PAM) is crucial for the last step of bioactive peptide biosynthesis. However, identification of a complete PAM-like gene in green algal genomes suggests ancient evolutionary roots for bioactive peptide signaling. We demonstrate that the Chlamydomonas reinhardtii PAM gene encodes an active peptide-amidating enzyme (CrPAM) that shares key structural and functional features with the mammalian enzyme, indicating that components of the peptide biosynthetic pathway predate multicellularity. In addition to its secretory pathway localization, CrPAM localizes to cilia and tightly associates with the axonemal superstructure, revealing a new axonemal enzyme activity. This localization pattern is conserved in mammals, with PAM present in both motile and immotile sensory cilia. The conserved ciliary localization of PAM adds to the known signaling capabilities of the eukaryotic cilium and provides a potential mechanistic link between peptidergic signaling and endocrine abnormalities commonly observed in ciliopathies.

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“…Subdistal appendages are important for mature centrioles to function as MT-anchoring centres during interphase [6,7], whereas distal appendages enable mature centrioles to function as basal bodies for the formation of cilia and flagella [8]. Considerations of phylogeny suggest that evolutionary conservation of centrioles correlates with the need of an organism to form ciliary structures during its life cycle [9,10]. As yeast do not form cilia, they do not rely on centriole-based centrosomes for the organization of MTs.…”

Section: Introductionmentioning

confidence: 99%

Centrosomes as signalling centres

Arquint

Gabryjonczyk

Nigg

2014

Phil. Trans. R. Soc. B

127

114

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Centrosomes—as well as the related spindle pole bodies (SPBs) of yeast—have been extensively studied from the perspective of their microtubule-organizing roles. Moreover, the biogenesis and duplication of these organelles have been the subject of much attention, and the importance of centrosomes and the centriole–ciliary apparatus for human disease is well recognized. Much less developed is our understanding of another facet of centrosomes and SPBs, namely their possible role as signalling centres. Yet, many signalling components, including kinases and phosphatases, have been associated with centrosomes and spindle poles, giving rise to the hypothesis that these organelles might serve as hubs for the integration and coordination of signalling pathways. In this review, we discuss a number of selected studies that bear on this notion. We cover different processes (cell cycle control, development, DNA damage response) and organisms (yeast, invertebrates and vertebrates), but have made no attempt to be comprehensive. This field is still young and although the concept of centrosomes and SPBs as signalling centres is attractive, it remains primarily a concept—in need of further scrutiny. We hope that this review will stimulate thought and experimentation.

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Tracing the origins of centrioles, cilia, and flagella

Cited by 344 publications

References 129 publications

Eukaryotic Flagella: Variations in Form, Function, and Composition during Evolution

Eukaryotic Flagella: Variations in Form, Function, and Composition during Evolution

Early eukaryotic origins for cilia-associated bioactive peptide-amidating activity

Centrosomes as signalling centres

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