Tracing the Dynamics of Stem Cell Fate

Chatzeli, Lemonia; Simons, Benjamin D.

doi:10.1101/cshperspect.a036202

Cited by 31 publications

(34 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is possible that Müller cells constitute a progenitor compartment under conditions of normal somatic growth, but are converted into facultative stem cells to participate in notochord regeneration. A similar conversion of tissue‐specific progenitor cells into facultative stem cells has recently been proposed for regenerating vertebrate tissues (Carriei et al, 2017; Chatzeli & Simmons, 2020).…”

Section: Resultsmentioning

confidence: 75%

Tail regeneration in a cephalochordate, the Bahamas lancelet,Asymmetron lucayanum

Holland

Somorjai

2020

Journal of Morphology

View full text Add to dashboard Cite

Lancelets (Phylum Chordata, subphylum Cephalochordata) readily regenerate a lost tail. Here, we use light microscopy and serial blockface scanning electron microscopy (SBSEM) to describe tail replacement in the Bahamas lancelet, Asymmetron lucayanum. One day after amputation, the monolayered epidermis has migrated over the wound surface. At 4 days, the regenerate is about 3% as long as the tail length removed. The re‐growing nerve cord is a tubular outgrowth of ependymal cells, and the new part of the notochord consists of several degenerating lamellar cells anterior to numerous small vacuolated cells. The cut edges of the mesothelium project into the regenerate as tubular extensions. These tubes anastomose with each other and with midline mesodermal canals beneath the regenerating edges of the dorsal and ventral fins. SBSEM did not reveal a blastema‐like aggregation of undifferentiated cells anywhere in the regenerate. At 6 days, the regenerate (10% of the amputated tail length) includes a notochord in which the small vacuolated cells mentioned above are differentiating into lamellar cells. At 10 days, the regenerate is 22% of the amputated tail length: myocytes have appeared in the walls of the myomeres, and sclerocoels have formed. By 14 days, the regenerate is 35% the length of the amputated tail, and the new tissues resemble smaller versions of those originally lost. The present results for A. lucayanum, a species regenerating quickly and with little inter‐specimen variability, provide the morphological background for future cell‐tracer, molecular genetic, and genomic studies of cephalochordate regeneration.

show abstract

Section: Resultsmentioning

confidence: 75%

Tail regeneration in a cephalochordate, the Bahamas lancelet,Asymmetron lucayanum

Holland

Somorjai

2020

Journal of Morphology

View full text Add to dashboard Cite

show abstract

“…Quantitative biophysical modeling of the resulting clonal size and composition led to strikingly reproducible interpretative models where SC pool maintenance involves a process referred to as “population asymmetry,” where individual SCs are endowed with equivalent potential, and choose stochastically between asymmetric division, amplification, or differentiation at each fate decision time point. Homeostatic mechanisms balance amplification and differentiation events at the population level (reviewed in [ 1,2 ] ). Such models predict clonal SC behavior in, for example, the interfollicular epidermis, the male germ line, intestinal crypts, and the esophageal epithelium in mouse, and in the human airway epithelium.…”

Section: Introduction – Homeostasis In Stem Cell Pools: Facts and Modelsmentioning

confidence: 99%

Neural stem cell pools in the vertebrate adult brain: Homeostasis from cell‐autonomous decisions or community rules?

2020

View full text Add to dashboard Cite

Adult stem cell populations must coordinate their own maintenance with the generation of differentiated cell types to sustain organ physiology, in a spatially controlled manner and over long periods. Quantitative analyses of clonal dynamics have revealed that, in epithelia, homeostasis is achieved at the population rather than at the single stem cell level, suggesting that feedback mechanisms coordinate stem cell maintenance and progeny generation. In the central nervous system, however, little is known of the possible community processes underlying neural stem cell maintenance. Recent work, in part based on intravital imaging made possible in the adult zebrafish, conclusively highlights that homeostasis in neural stem cell pools may rely on population asymmetry and long‐term spatiotemporal coordination of neural stem cell states and fates. These results suggest that neural stem cell assemblies in the vertebrate brain behave as self‐organized systems, such that the stem cells themselves generate their own intrinsic niche.

show abstract

“… 17 The formation of two daughter cells from cell division, 36 , 37 the division into two cells, 17 , 37 , 38 or separation of a stem cell from the parent cell to produce two daughters are the potential fate of stem cell differentiation. 39 Until differentiating into more advanced progenitor cells, it produces multiple folds of cells in a systematic way. 40 , 41 …”

Section: Fate Of Pluripotent and Multipotent Cellsmentioning

confidence: 99%

Pluripotent and Multipotent Stem Cells and Current Therapeutic Applications: Review

Worku¹

2021

SCCAA

View full text Add to dashboard Cite

There is numerous evidence for the presence of stem cells, which is important for the treatment of a wide variety of disease conditions. Stem cells have a great therapeutic effect on different degenerative diseases through the development of specialized cells. Embryonic stem (ES) cells are derived from preimplantation embryos, which have a natural karyotype. This cell has the capacity of proliferation indefinitely and undifferentiated. Stem cells are very crucial for the treatment of different chronic and degenerative diseases. For instance, stem cell clinical trials have been done for ischemic heart disease. Also, the olfactory cells for spinal cord lesions and human fetal pancreatic cells for diabetes mellitus are the other clinical importance of stem cell therapy. Extracellular matrix (ECM) and other environmental factors influence the fate and activity of stem cells.

show abstract

Tracing the Dynamics of Stem Cell Fate

Cited by 31 publications

References 117 publications

Tail regeneration in a cephalochordate, the Bahamas lancelet,Asymmetron lucayanum

Tail regeneration in a cephalochordate, the Bahamas lancelet,Asymmetron lucayanum

Neural stem cell pools in the vertebrate adult brain: Homeostasis from cell‐autonomous decisions or community rules?

Pluripotent and Multipotent Stem Cells and Current Therapeutic Applications: Review

Contact Info

Product

Resources

About