Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states

Andersen, Marianne S.; Hannezo, Édouard; Ulyanchenko, Svetlana; Estrach, Soline; Antoku, Yasuko; Pisano, Sabrina; Boonekamp, Kim E.; Sendrup, Sarah; Maimets, Martti; Pedersen, Marianne Terndrup; Johansen, Jens Vilstrup; Clement, Ditte L.; Feral, Chloé C.; Simons, Benjamin D.; Jensen, Kim B.

doi:10.1038/s41556-019-0362-x

Cited by 30 publications

(40 citation statements)

References 40 publications

(45 reference statements)

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“…To identify the mechanisms that underlie the switch in cell behavior, we focused on one of the first, and most important, transitions that a specified tissue faces; the establishment of homeostasis. In many tissues, development continues after birth with an extremely rapid but physiological level of expansion that encompasses the postnatal growth of the animal, and culminates in the establishment of homeostasis 11, 12 . Once the homeostatic steady state is achieved, adult epithelial cells have been shown to retain the ability to repurpose certain developmental features as a mechanism to promote their plasticity and enhance their regenerative capacity 6, 13, 14 .…”

Section: Mainmentioning

confidence: 99%

A biomechanical switch regulates the transition towards homeostasis in esophageal epithelium

McGinn

Hallou

Han

et al. 2021

Preprint

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Epithelial cells are highly dynamic and can rapidly adapt their behavior in response to tissue perturbations and increasing tissue demands. However, the processes that finely control these responses and, particularly, the mechanisms that ensure the correct switch to and from normal tissue homeostasis are largely unknown. Here we explore changes in cell behavior happening at the interface between postnatal development and homeostasis in the epithelium of the mouse esophagus, as a physiological model exemplifying a rapid but controlled tissue growth transition. Single cell RNA sequencing and histological analysis of the mouse esophagus reveal significant mechanical changes in the epithelium upon tissue maturation. Organ stretching experiments further indicate that tissue strain caused by the differential growth of the mouse esophagus relative to the entire body promotes the emergence of a defined committed population in the progenitor compartment as homeostasis is established. Our results point to a simple mechanism whereby the mechanical changes experienced at the whole tissue level are integrated with those 'sensed' at the cellular level to control epithelial cell behavior and tissue maintenance.

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Section: Mainmentioning

confidence: 99%

A biomechanical switch regulates the transition towards homeostasis in esophageal epithelium

McGinn

Hallou

Han

et al. 2021

Preprint

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“…Aging-associated changes [ 127,128] Ionizing irradiation X-ray, -radiation, UV light Cancer regression accompanied by side effects [ 125,126] Oncogene activation HRas, KRas, NRas, BRAF Cancer progression or suppression [129][130][131] Loss of tumor suppressors p53, PTEN Tumor inhibition; cancer progression [ 132,133] Oxidative stress Inducers of reactive oxygen species (e.g., paraquat, hydrogen peroxide)…”

Section: The Biology and Impact Of Cellular Senescencementioning

confidence: 99%

Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

et al. 2020

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Aging is a physiological decline in both structural homeostasis and functional integrity, progressively affecting organismal health. A major hallmark of aging is the accumulation of senescent cells, which have entered a state of irreversible cell cycle arrest after experiencing inherent or environmental stresses. Although cellular senescence is essential in several physiological events, it plays a detrimental role in a large array of age-related pathologies. Recent biomedical advances in specifically targeting senescent cells to improve healthy aging, or alternatively, postpone natural aging and age-related diseases, a strategy termed senotherapy, have attracted substantial interest in both scientific and medical communities. Challenges for aging research are highlighted and potential avenues that can be leveraged for therapeutic interventions to control aging and age-related disorders in the current era of precision medicine.

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“…36,47 Clonal tracing studies also revealed that the sebaceous duct is an integral part of the infundibulum rather than the SG. 36 The differentiation of sebaceous duct cells is controlled by GATA6 (GATA-binding factor 6), a transcription factor that is upregulated in Lrig1 progeny 48,49 (Figure 1B). Together, the results point to a dual fate of Lrig1-positive stem cells giving rise either to the SG or the sebaceous duct and infundibulum.…”

Section: S Tem Cell S In S Ebaceous G L and Homeos Ta S Ismentioning

confidence: 99%

“…Furthermore, a release from the spatial confinement of the SG was associated with a reduction in matrix stiffness pointing to a potential role of mechanical properties of the stroma surrounding the SG. 36 Whole-exome sequencing of human sebaceous carcinoma demonstrated distinct tumor subtypes based on mutational genetics. 86 Tumor subtypes are dominated by either mismatch repairderived insertions and deletions or by an ultraviolet (UV)-induced signature of single nucleotide mutations.…”

Section: S Ebaceous G L and S Tem Cell S And C An Cermentioning

confidence: 99%

Stem and progenitor cells in sebaceous gland development, homeostasis and pathologies

Geueke

Niemann

2021

Experimental Dermatology

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Sebaceous glands (SGs) are acinar holocrine-secreting appendages of the epidermis and localize to most areas of the body surface. 1 Generally, SGs constitute a crucial component of the pilosebaceous unit and are intimately associated with the junctional zone (JZ), an area of the upper and permanent part of the hair follicle (HF). While the outer layer of the SG contains proliferative cells, the inner compartment is composed of sebocytes, specialized keratinocytes, that produce a mixture of an oily and waxy material, called sebum. [1][2][3] Upon differentiation and maturation of sebocytes, the lipidcontaining sebum is released by holocrine secretion through a specialized secretory duct of the gland into the follicular canal to reach the surface of the skin. 4 This complex mixture of lipids contributes significantly to the barrier function of mammalian skin by reducing water loss from the surface of the skin and facilitates water repulsion and thermoregulation. 1,5 Although all the details of the physiological complexity of SGs are not completely understood, sebum has antimicrobial activity, contains antioxidants and protects against UVB-induced apoptosis. 1,4,[6][7][8] Distinct regions of the skin and surface epithelium generate SGs independently from HF structures, e.g.

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Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states

Cited by 30 publications

References 40 publications

A biomechanical switch regulates the transition towards homeostasis in esophageal epithelium

A biomechanical switch regulates the transition towards homeostasis in esophageal epithelium

Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities

Stem and progenitor cells in sebaceous gland development, homeostasis and pathologies

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