Abstract:<p>Evolution of metabolism is a longstanding yet unresolved question, and
several hypotheses were proposed to address this complex process from a
Darwinian point of view. Modern statistical bioinformatic approaches targeted to the comparative
analysis of genomes are being used to detect signatures of natural selection at
the gene and population level, as an attempt to understand the origin of
primordial metabolism and its expansion. These studies, however, are still mainly
centered on genes and the prote… Show more
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