“…I t is held th a t tracheostom y should be postponed u n til an acu te d eterioration of the p a tie n t's condition m akes its in stitu tio n m an d ato ry [6,18]. In view of th e im provem ent of v en tilato ry fu n c tion afte r tracheostom y [6,9,14,17] it appears justified, however, to stu d y the effect of reduction of anatom ical dead space in these p a tie n ts before onset of an acute episode of respiratory failure so as ev en tu ally to take steps aim ed at perm anent reduction of dead space.At th e end of expiration dead space betw een the carina and th e ex tern al orifices of th e airw ays m ainly contains air w ith the com position of alveolar air; could this p a rt of dead space be elim inated, tid al air would be decreased by a corresponding volum e. F urth erm o re, C 0 2 norm ally contained in this p a rt of th e airw ays no longer would be re b rea th e d , leading to a decrease in m inute ventilation as a physio logical response set to m aintain the existing P a C 0 2 level [21], The decrease in m inute volum e of v en tilatio n will th u s be determ ined by the influence of reduction in dead space on the P a C 0 2 level. E ven in conditions of chronic hypercarbia this level is kept in a ra th e r narrow range th roughout daily fluctuations [3], W henever increase in respira tory dead space is a prom inent pathological feature, reduction in its size should be valuable.…”