Tracheobronchiomegaly

Aaby, Gene V.; Blake, Hu A.

doi:10.1016/s0003-4975(10)66538-1

Cited by 52 publications

(13 citation statements)

References 4 publications

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“…Tracheobronchomegaly is characterized by severe dilatation of the trachea and main bronchi and is believed to be due to degeneration of elastic tissue in the trachea (Hasleton, 1996). A rare congenital form of tracheobronchomegaly (Mounier-Kuhn syndrome) has been reported in children with cutis laxa (Aaby and Blake, 1966;Wanderer et al, 1969), and in association with Marfan syndrome (Shivaram et al, 1990)-both of these conditions are genetic disorders of elastin synthesis. Finally, the effect of elastin degeneration with advancing age may be important.…”

Section: Discussion Elastic Fibers In the Trachea And Bronchimentioning

confidence: 99%

Novel insights into the elastic and muscular components of the human trachea

2009

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Despite its probable importance in health and disease, the elastic tissue in the trachea has rarely been investigated. In addition, various aspects of the trachealis muscle are controversial. The aim of this study was to clarify this clinically relevant anatomy. Ten cadaveric tracheobronchial specimens (age range 68-101 years; seven males; no major airway pathology) were qualitatively investigated by microdissection. Serial histologic sections from multiple sites in three specimens were analyzed after staining for elastin. Findings were correlated with observations from video tracheobronchoscopies. An extensive and prominent meshwork of elastic tissue was found within the trachea and bronchi. Elastic fibers were predominantly longitudinal and aggregated into discrete bundles within the membranous wall of the trachea and main bronchi; a discrete fibroelastic membrane bridging the membranous wall of the trachea; and vertical laminae connecting the ends of successive cartilages. The longitudinal elastic bundles continued into the segmental bronchi, becoming thinner and more circumferentially distributed. Trachealis consisted of a transverse layer of smooth muscle deep to the fibroelastic membrane of the membranous wall of the trachea, together with scattered longitudinal muscle bundles, mostly embedded within the fibroelastic membrane in the distal half of the trachea. In conclusion, there is an extensive but relatively neglected elastic framework within the tracheobronchial tree. This is likely to have major clinical relevance to the pathophysiology of respiratory disease and ageing. The trachealis muscle is more complex than previously stated.

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Section: Discussion Elastic Fibers In the Trachea And Bronchimentioning

confidence: 99%

Novel insights into the elastic and muscular components of the human trachea

2009

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“…It has been suggested that a congenital con nective tissue defect could be responsible [9]. This is corroborated by the occasional association of TBM with Ehler-Danlos syndrome [10] and cutis laxa [11]. Other authors consider TBM an acquired disease [12,13], Parris and Johnson [13] presented a case of an adult TBM secondary to intensive radiotherapy.…”

Section: Discussionmentioning

confidence: 98%

Tracheobronchomegaly Associated with Interstitial Pulmonary Fibrosis

Vidal

Peña²,

Mosquera³

et al. 1991

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“…The aetiology of this rare syndrome is not clearly understood, although associations with cutis laxa in children [2], Ehlers-Danlos syndrome in adults [3], occurrence in two siblings [4] and absence of tracheobronchial muscle fibres and myenteric plexus [5] suggest that a developmental or congenital connective tissue defect is responsible for this disease. However, presentation of tracheobronchomegaly in the third or fourth decade of life and the absence of a connective tissue disorder in most cases favour an acquired cause.…”

Section: Discussionmentioning

confidence: 99%