Tracheobronchial calcification: an observation in three children after mitral valve replacement and warfarin sodium therapy.

Taybi, Hooshang; Capitanio, Marie A.

doi:10.1148/radiology.176.3.2389031

Cited by 54 publications

(10 citation statements)

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“…153,154 Nonhemorrhagic complications of VKAs, such as tracheal calcifi cation or hair loss, have been described on rare occasions in young children. 155,156 Two cohort studies described reduced bone density in children receiving warfarin for . 1 year.…”

Section: Adverse Effects Of Vkasmentioning

confidence: 99%

Antithrombotic Therapy in Neonates and Children

Monagle

Chan

Goldenberg

et al. 2012

Chest

1,236

559

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Section: Adverse Effects Of Vkasmentioning

confidence: 99%

Antithrombotic Therapy in Neonates and Children

Monagle

Chan

Goldenberg

et al. 2012

Chest

1,236

559

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“…19 Overexpression of MGP was shown to inhibit normal chondrocyte and cartilage mineralization, 20 whereas inhibi-tion of MGP maturation by warfarin treatment induced calcification of cartilage and aorta, both in animals [21][22][23] and humans. 24,25 Moreover, in aortas, mineralization induced by warfarin was observed limited to elastic fibers, in the absence of necrotic material, and therefore attributable to an active process. 22,26 Therefore, defects in MGP carboxylation seems to be associated with elastin mineralization.…”

mentioning

confidence: 99%

Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients

Gheduzzi

Boraldi

Annovi

et al. 2007

Laboratory Investigation

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Mature MGP (Matrix g-carboxyglutamic acid protein) is known to inhibit soft connective tissues calcification. We investigated its possible involvement in pseudoxanthoma elasticum (PXE), a genetic disorder whose clinical manifestations are due to mineralization of elastic fibers. PXE patients have lower serum concentration of total MGP compared to controls (Po0.001). Antibodies specific for the noncarboxylated (Glu-MGP) and for the g-carboxylated (Gla-MGP) forms of MGP were assayed on ultrathin sections of dermis from controls and PXE patients. Normal elastic fibers in controls and patients were slightly positive for both forms of MGP, whereas Gla-MGP was more abundant within control's than within patient's elastic fibers (Po0.001). In patients' calcified elastic fibers, Glu-MGP intensively colocalized with mineral precipitates, whereas Gla-MGP precisely localized at the mineralization front. Data suggest that MGP is present within elastic fibers and is associated with calcification of dermal elastic fibers in PXE. To investigate whether local cells produce MGP, dermal fibroblasts were cultured in vitro and MGP was assayed at mRNA and protein levels. In spite of very similar MGP mRNA expression, cells from PXE patients produced 30% less of Gla-MGP compared to controls. Data were confirmed by immunocytochemistry on ultrathin sections. Normal fibroblasts in vitro were positive for both forms of MGP. PXE fibroblasts were positive for Glu-MGP and only barely positive for Gla-MGP (Po0.001). In conclusion, MGP is involved in elastic fiber calcification in PXE. The lower ratio of Gla-MGP over Glu-MGP in pathological fibroblasts compared to controls suggests these cells may play an important role in the ectopic calcification in PXE.

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“…31,32 Antiplatelet therapy ( Figure 3) Aspirin 21,33 Inhibition of COX-1 and COX-2 activity • With 0.4-1.0 OD units, the probability of platelet-activating antibodies being present (and hence a diagnosis of HIT being tenable), was very low (≈5%).…”

Section: Lmwh Level 4-6 H After Dosementioning

confidence: 99%