Tracheobronchial Amyloidosis: A Case Report and Review of the Literature

Birkeland, Andrew C.; McHugh, Jonathan B.; Spector, Matthew E.

doi:10.4303/jcrm/235859

Cited by 13 publications

(14 citation statements)

References 10 publications

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“…Tracheobronchial amyloidosis, manifested by amyloid deposits limited specifically to tracheal and bronchial tissue, is a rare disorder with only a few hundred published cases [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] . Patients classically present with non-specific symptoms related to fixed upper airway obstruction caused by tracheal stenosis [9] .…”

Section: Discussionmentioning

confidence: 99%

Tracheobronchial amyloidosis: A case report and review of literature

Crain

Lakhani

Balar

et al. 2021

Radiology Case Reports

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Tracheobronchial amyloidosis, manifested by amyloid deposits limited specifically to tracheal and bronchial tissue, is a rare manifestation with only a few hundred published cases. Patients classically present with symptoms related to fixed upper airway obstruction caused by tracheal stenosis. Clinical symptoms are non-specific and include hoarseness, dyspnea, cough, stridor, hemoptysis, and dysphagia, which are similar to those caused by more common airway disorders, often leading to incorrect, missed, and delayed diagnosis. The wide-spread use of computerized tomography (CT) imaging has the potential of dramatically advancing the early diagnosis of tracheobronchial amyloidosis. We present a case of a patient with chronic and progressive hoarseness, diagnosed with tracheobronchial amyloidosis, with a focus on unusually clear and precise CT soft tissue neck imaging. CT imaging demonstrated nodular circumferential raised mass-like thickening involving the long-segment posterior wall of the distal trachea. The wall thickening also extended into the proximal left main stem bronchi, but spared the distal bronchial tree. This resulted in moderate (approximately 50%) narrowing of the tracheal lumen, which explained the patient's hoarseness. Routine CT imaging of patients with chronic and progressive respiratory symptoms, including cough, hoarseness, and dyspnea, is recommended. Tracheobronchial amyloidosis is an uncommon disease, but it may become more commonly recognized with broader use of more effective CT imaging protocols.

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Section: Discussionmentioning

confidence: 99%

Tracheobronchial amyloidosis: A case report and review of literature

Crain

Lakhani

Balar

et al. 2021

Radiology Case Reports

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“…The role of pharmacological drug therapy in TBA is unclear; however, it has been used in systemic diseases. The various drugs which have been tried are melphalan, dexamethasone, bortezomib, and haematopoietic stem cell transplantation with variable response [13].…”

Section: Discussionmentioning

confidence: 99%

Tracheobronchial amyloidosis: an uncommon disease with a common presentation

Mangla

Vadala

Kadli

et al. 2020

Respirology Case Reports

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Amyloidosis is an uncommon heterogeneous and multi‐systemic disease characterized by extracellular amyloid deposition. The size of proteins varies and forms a part of local disease or systemic process. Light chain amyloidosis (AL) is the most prevalent form of systemic amyloidosis which may also be seen in localized disease. Isolated tracheobronchial amyloidosis (TBA) is rather unusual with local amyloid deposition which may pose a diagnostic dilemma with subsequent therapeutic challenge. Awareness of such a presentation is crucial in the diagnosis of this rare disease. We describe three cases who presented with haemoptysis, which on further evaluation were diagnosed as isolated TBA, and a review of literature.

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“…Sarcomatoid chromophobe RCC frequently have multiple gains (polysomy) of chromosomes 1, 2, 6, 10 and 17 [6].…”

Section: Discussionmentioning

confidence: 99%

Recurrent metastatic clear cell renal carcinoma with sarcomatoid dedifferentiation treated with surgery and Cabozantinib

et al. 2020

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Renal cell carcinoma with sarcomatoid dedifferentiation is an entity of RCC that has undergone an anaplastic transformation with both a carcinomatous and a sarcomatous component. The standard treatment in metastatic patients is immunotherapy. The aim of this article is to describe our case of metastatic recurrent RCC with sarcomatoid dedifferentiation in a 59 year old male patient treated with nephrectomy and multiple metastasectomies followed by Cabozantinib. Consecutive PET-CT scans showed no evidence of recurrence, three years after the last metastasectomy, and the patient is having currently a normal life. Sarcomatoid dedifferentiation remains a poor prognosis factor in RCC. Surgery for metastases followed by Cabozantinib may be a therapeutic option in metastatic young patients. However, a prospective randomized trial would be the best option to validate this approach.

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Tracheobronchial Amyloidosis: A Case Report and Review of the Literature

Cited by 13 publications

References 10 publications

Tracheobronchial amyloidosis: A case report and review of literature

Tracheobronchial amyloidosis: A case report and review of literature

Tracheobronchial amyloidosis: an uncommon disease with a common presentation

Recurrent metastatic clear cell renal carcinoma with sarcomatoid dedifferentiation treated with surgery and Cabozantinib

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