Tracheal telocytes

Rusu, Mugurel Constantin; Jianu, Adelina Maria; Mirancea, Nicolae; Didilescu, Andreea Cristiana; Mănoiu, Vasile Sorin; Păduraru, D

doi:10.1111/j.1582-4934.2011.01465.x

Cited by 58 publications

(32 citation statements)

References 24 publications

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“…A peculiar type of interstitial (stromal) cells named telocytes (TCs; cell bearing long prolongations/stromal cells with telopodes – Tps ‐) has been described and adopted by several laboratories [for review see and for details visit http://www.telocytes.com]. Formerly called interstitial‐like (Cajal‐like) cells, TCs have been observed in several tissues and organs, including skin, respiratory tract, cardiovascular system, gastrointestinal tract, liver, gallbladder, pancreas, parotid gland, female reproductive system, breast, placenta, urinary tract and meninges and choroid plexus .…”

Section: Introductionmentioning

confidence: 99%

Telocytes in neuromuscular spindles

Díaz‐Flores

Gutiérrez

Sáez

et al. 2013

J Cellular Molecular Medi

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A new cell type named telocyte (TC) has recently been identified in various stromal tissues, including skeletal muscle interstitium. The aim of this study was to investigate by means of light (conventional and immunohistochemical procedures) and electron microscopy the presence of TCs in adult human neuromuscular spindles (NMSs) and lay the foundations for future research on their behaviour during human foetal development and in skeletal muscle pathology. A large number of TCs were observed in NMSs and were characterized ultrastructurally by very long, initially thin, moniliform prolongations (telopodes – Tps), in which thin segments (podomeres) alternated with dilations (podoms). TCs formed the innermost and (partially) the outermost layers of the external NMS capsule and the entire NMS internal capsule. In the latter, the Tps were organized in a dense network, which surrounded intrafusal striated muscle cells, nerve fibres and vessels, suggesting a passive and active role in controlling NMS activity, including their participation in cell-to-cell signalling. Immunohistochemically, TCs expressed vimentin, CD34 and occasionally c-kit/CD117. In human foetus (22–23 weeks of gestational age), TCs and perineural cells formed a sheath, serving as an interconnection guide for the intrafusal structures. In pathological conditions, the number of CD34-positive TCs increased in residual NMSs between infiltrative musculoaponeurotic fibromatosis and varied in NMSs surrounded by lymphocytic infiltrate in inflammatory myopathy. We conclude that TCs are numerous in NMSs (where striated muscle cells, nerves and vessels converge), which provide an ideal microanatomic structure for TC study.

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Section: Introductionmentioning

confidence: 99%

Telocytes in neuromuscular spindles

Díaz‐Flores

Gutiérrez

Sáez

et al. 2013

J Cellular Molecular Medi

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“…FIB-SEM tomography, the most advanced and powerful technique to visualize cells confirmed the existence of TCs [16]. Since their identification in 2010, TCs have been found in various mammalian organs and tissues and contribute to form a complex interstitial network for the maintenance of tissue homeostasis, such as heart [17][18][19][20][21], lung [22][23][24], placenta [25], pancreas [26,27], skin [28,29], skeletal muscle [30][31][32], uterus [33][34][35][36][37][38], urinary system [39][40][41], and others [42][43][44][45][46][47][48][49][50][51][52][53][54][55]. Furthermore, increasing evidence has demonstrated the presence of TCs within stem cell niches [23,29,31,49,56,57] and indicated the potential involvement of TCs in tissue regeneration/r...…”

Section: Introductionmentioning

confidence: 99%

Telocytes in Pregnancy-Induced Physiological Liver Growth

Wang

Bei

Zhao

et al. 2015

Cell Physiol Biochem

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Background/Aims: We previously documented the presence of Telocytes (TCs) in liver and further indicated the potential roles of TCs in liver regeneration after hepatectomy. Pregnancy-induced liver growth, other than liver regeneration after hepatectomy, is a physiological hepatic adaption to meet the enhanced nutritional and metabolic demands. However, the possible roles of TCs in pregnancy-induced liver growth remain unknown. Methods: Pregnant mice were sacrificed at different time points (pregnancy day 0.5, 4.5, 8.5, 10.5, 12.5, 14.5, 16.5, and 18.5). The liver weight was used to evaluate the liver growth during pregnancy. Hepatocytes proliferation was determined by albumin and 5-ethynyl-2'- deoxyuridine (EdU) double immunostaining while TCs were counted by double immunolabeling for CD34/PDGFR-α. Results: Pregnancy-induced liver growth was preceded by increased proliferation of hepatocytes at pregnancy day 4.5, 8.5, 14.5 and 16.5. Furthermore, the number of TCs in liver detected by double immunolabeling for CD34/PDGFR-α was significantly increased at pregnancy day 4.5 and day 14.5, that was coincident with the occurrence of two peaks of hepatic cell proliferation during pregnancy. Conclusion: Our results suggest a possible relationship between TCs and hepatocyte proliferation in pregnancy-induced liver growth.

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“…Following ether anesthesia, the animals were euthanatized as described elsewhere [Rusu et al, 2012a[Rusu et al, , 2012d. The study also included 10 autopsy samples of human urinary bladder anterior wall (56-to 73-year-old donor cadavers, 6 males and 4 females).…”

Section: Methodsmentioning

confidence: 99%

Suburothelial Interstitial Cells

Rusu¹,

Folescu

Mănoiu

et al. 2014

Cells Tissues Organs

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The suburothelium has received renewed interest because of its role in sensing bladder fullness. Various studies evaluated suburothelial myofibroblasts (MFs), interstitial cells (ICs), interstitial Cajal cells (ICCs) or telocytes (TCs), which resulted in inconsistencies in terminology and difficulties in understanding the suburothelial structure. In order to elucidate these issues, the use of electron microscopy seems to be an ideal choice. It was hypothesized that the cell population of the suburothelial band is heterogeneous in an attempt to clarify the above-mentioned inconsistencies. The suburothelial ICs of the bladder were evaluated by immunohistochemistry (IHC) and transmission electron microscopy (TEM). Bladder samples from 6 Wistar rats were used for IHC and TEM studies and human bladder autopsy samples were used for IHC. Desmin labeled only the detrusor muscle, while all the myoid structures of the bladder wall were positive for α-smooth muscle actin (SMA). A distinctive α-SMA-positive suburothelial layer was identified. A layered structure of the immediate suburothelial band was detected using TEM: (1) the inner suburothelial layer consisted of fibroblasts equipped for matrix synthesis; (2) the middle suburothelial layer consisted of smooth muscle cells (SMCs) and myoid ICCs, and (3) the outer suburothelial layer consisted of ICs with TC morphology, building a distinctive network. In conclusion, the suburothelial layer consists of distinctive types of ICs but not MFs. The myoid layer, with SMCs and ICCs, which could be considered identical to the α-SMA-positive cells in the suburothelial band, seems the best-equipped layer for pacemaking and signaling. Noteworthy, the network of ICs also seems suitable for stromal signaling.

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Tracheal telocytes

Cited by 58 publications

References 24 publications

Telocytes in neuromuscular spindles

Telocytes in neuromuscular spindles

Telocytes in Pregnancy-Induced Physiological Liver Growth

Suburothelial Interstitial Cells

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