Tracheal regeneration using polycaprolactone/collagen-nanofiber coated with umbilical cord serum after partial resection

Jang, Yoon Seok; Jang, Chul Ho; Cho, Yong Beom; Kim, Minseong; Kim, GeunHyung

doi:10.1016/j.ijporl.2014.10.022

Cited by 26 publications

(25 citation statements)

References 31 publications

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Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

“…Jang, Jang, Cho, Kim, and Kim () fabricated PCL–collagen electrospun scaffold and modified with human umbilical cord serum. The fabricated scaffold was implanted in 4 × 8‐mm anterior tracheal defect in rats, and at 7 weeks of postsurgery, nanofibrous scaffold showed complete cartilaginous tissue regeneration and luminal epithelization without any in vivo inflammatory response (Jang et al, ). In another case, polyethylene terephthalate and polyurethane (PET/PU) nanofibrous scaffold was seeded with autologous bone marrow‐derived mononuclear cells and placed in a bioreactor and after that regenerated into fully vascularized tissue with epithelial and mucosal layer formation in rat model (Ajalloueian et al, ).…”

Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

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Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Dhasmana

Singh

2020

J Tissue Eng Regen Med

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Airway system is a vital part of the living being body. Trachea is the upper respiratory portion that connects nostril and lungs and has multiple functions such as breathing and entrapment of dust/pathogen particles. Tracheal reconstruction by artificial prosthesis, stents, and grafts are performed clinically for the repairing of damaged tissue. Although these (above-mentioned) methods repair the damaged parts, they have limited applicability like small area wounds and lack of functional tissue regeneration. Tissue engineering helps to overcome the abovementioned problems by modifying the traditional used stents and grafts, not only repair but also regenerate the damaged area to functional tissue. Bioengineered tracheal replacements are biocompatible, nontoxic, porous, and having 3D biomimetic ultrastructure with good mechanical strength, which results in faster and better tissue regeneration. Till date, the bioengineered tracheal replacements studies have been going on preclinical and clinical levels. Besides that, still many researchers are working at advance level to make extracellular matrix-based acellular, 3D printed, cell-seeded grafts including living cells to overcome the demand of tissue or organ and making the ready to use tracheal reconstructs for clinical application. Thus, in this review, we summarized the tracheal tissue engineering aspects and their outcomes. K E Y W O R D S biocompatible, chondrocytes, ECM, in vivo, tissue engineering, trachea

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Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Dhasmana

Singh

2020

J Tissue Eng Regen Med

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“…Various studies describing the usage of small rectangular shapes show no evidence of stenosis and minimal granulation tissue over time. Histology displays regeneration of ciliated epithelium and neuro-vascularization on luminal surface (Park et al, 2018a;Park et al, 2012;Kwon et al, 2014;Jang et al, 2014). When larger defects were created and repaired on larger animals, results are variable.…”

Section: Non-circumferential Reconstructionmentioning

confidence: 99%

3D-bioprinted tracheal reconstruction: an overview

Frejo

Grande

2019

Bioelectron Med

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Congenital tracheomalacia and tracheal stenosis are commonly seen in premature infants. In adulthood, are typically related with chronic obstructive pulmonary disease, and can occur secondarily from tracheostomy, prolong intubation, trauma, infection and tumors. Both conditions are life-threatening when not managed properly. There are still some surgical limitations for certain pathologies, however tissue engineering is a promising approach to treat massive airway dysfunctions. 3D-bioprinting have contributed to current preclinical and clinical efforts in airway reconstruction. Several strategies have been used to overcome the difficulty of airway reconstruction such as scaffold materials, construct designs, cellular types, biologic components, hydrogels and animal models used in tracheal reconstruction. Nevertheless, additional long-term in vivo studies need to be performed to assess the efficacy and safety of tissue-engineered tracheal grafts in terms of mechanical properties, behavior and, the possibility of further stenosis development.

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“…Previously, we have reported on the excellent effects of polycaprolactone/collagen nanofiber (PCL/CoNF) combined with hUCS for bone regeneration and tracheal regeneration [14,15].…”

Section: Introductionmentioning

confidence: 99%

Effect of polycaprolactone/collagen/hUCS microfiber nerve conduit on facial nerve regeneration

Jang

Lee

Kim

et al. 2016

International Journal of Biological Macromolecules

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Tracheal regeneration using polycaprolactone/collagen-nanofiber coated with umbilical cord serum after partial resection

Cited by 26 publications

References 31 publications

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

3D-bioprinted tracheal reconstruction: an overview

Effect of polycaprolactone/collagen/hUCS microfiber nerve conduit on facial nerve regeneration

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