Tracheal Reconstruction

Janssen, Luuk M.; Osch, Gerjo J. V. M. van; Li, Jia Ping; Kops, Nicole; Groot, K. de; Hoff, Johannes W. Von den; Feenstra, Louw; Hardillo, José A.

doi:10.1001/archoto.2009.29

Cited by 14 publications

(3 citation statements)

References 27 publications

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“…Furthermore it has good initial stability and is well tolerated by tissues as it does not evoke foreign body reactions [14]. In general, a porous implant structure is favorable for improving ingrowth of blood vessels and bone, as well as for overcoming the mismatch between the Young’s modulus between bone (10–30 GPa) and titanium (about 110 GPa for Ti6Al4V), which can lead to stress-shielding and, consequently, to loosening of the implant-bone interface [15,16].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Functionalized Porous Titanium Implants for Enhancing Angiogenesis in Vitro

et al. 2016

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Implant constructs supporting angiogenesis are favorable for treating critically-sized bone defects, as ingrowth of capillaries towards the center of large defects is often insufficient. Consequently, the insufficient nutritional supply of these regions leads to impaired bone healing. Implants with specially designed angiogenic supporting geometry and functionalized with proangiogenic cytokines can enhance angiogenesis. In this study, Vascular Endothelial Growth Factor (VEGF) and High Mobility Group Box 1 (HMGB1) were used for incorporation into poly-ε-caprolactone (PCL)-coated porous titanium implants. Bioactivity of released factors and influence on angiogenesis of functionalized implants were evaluated using a migration assay and angiogenesis assays. Both implants released angiogenic factors, inducing migration of endothelial cells. Also, VEGF-functionalized PCL-coated titanium implants enhanced angiogenesis in vitro. Both factors were rapidly released in high doses from the implant coating during the first 72 h.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Functionalized Porous Titanium Implants for Enhancing Angiogenesis in Vitro

et al. 2016

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“…Furthermore, it was also discovered in the craniofacial surgery that after 1 year implantation, the surface of the titanium plate was generally covered with dense, fibrous connective tissue (Armencea et al, 2019). Janseen et al found the porous titanium is suitable for the soft tissue ingrowth and combination (Janssen et al, 2009). He used a porous titanium mesh to reconstruct a tracheal support placed under the mucosa of rabbit trachea.…”

Section: Discussionmentioning

confidence: 99%

A Novel Design of Temporomandibular Joint Prosthesis for Lateral Pterygoid Muscle Attachment: A Preliminary Study

Zou

Zhong

Xiong

et al. 2021

Front. Bioeng. Biotechnol.

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Introduction: In temporomandibular joint (TMJ) replacement operation, due to the condylectomy, the lateral pterygoid muscle (LPM) lost attachment and had impact on the mandible kinematic function. This study aimed to design a novel TMJ replacement prosthesis for LPM attachment and to verify its feasibility by preliminary in vitro and in vivo experiments.Materials and Methods: An artificial TMJ prosthesis designed with a porous structure on the condylar neck region for LPM attachment was fabricated by a 3D printed titanium (Ti) alloy. A rat myoblast cell line (L6) was tested for adhesion and biocompatibility with porous titanium scaffolds in vitro by cell counting Kit-8 (CCK-8), scanning electron microscope (SEM), flow cytometry (FCM), real-time quantitative polymerase chain reaction (RT-qPCR), immunocytofluorescense, western blotting, etc. The porous titanium scaffolds were further embedded in the rat intervertebral muscle to analyze muscle growth and biomechanical strength in vivo. The novel artificial TMJ prosthesis was implanted to reconstruct the goat's condyle and LPM reattachment was analyzed by hard tissue section and avulsion force test.Results: L6 muscle cells showed good proliferation potential on the porous Ti scaffold under SEM scanning and FCM test. In RT-qPCR, immunocytofluorescense and western blotting tests, the L6 cell lines had good myogenic capacity when cultured on the scaffold with high expression of factors such as Myod1 and myoglobin, etc. In the in vivo experiment, muscles penetrated into the porous scaffold in both rats and goats. In rat's intervertebral muscle implantation, the avulsion force was 0.716 N/mm2 in 4 weeks after operation and was significantly increased to 0.801 N/mm2 at 8 weeks (p < 0.05). In goat condylar reconstruction with the porous scaffold prosthesis, muscles attached to the prosthesis with the avulsion force of 0.436 N/mm2 at 8 weeks, but was smaller than the biological muscle-bone attachment force.Conclusion: The novel designed TMJ prosthesis can help LPM attach to its porous titanium scaffold structure area for future function.

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“…[4] Utilization of metallic foams enables utilization of titanium in soft tissue applications such as tracheal replacement where mechanical properties of the structure are vital. [5] In such structures, understanding the mechanisms of the interactions of the 3D titanium structures with soft tissues is important, but it has not been as widely studied as the interaction of titanium with hard tissues.…”

Section: Introductionmentioning

confidence: 99%

Titanium Microbead‐Based Porous Implants: Bead Size Controls Cell Response and Host Integration

Vrana

Dupret‐Bories

Schultz

et al. 2013

Adv Healthcare Materials

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Openly porous structures in implants are desirable for better integration with the host tissue. Sintered microbead-based titanium implants for oto-rhinolaryngology applications, which create an environment where the cells can migrate in the areas between the microbeads, are developed. This structure promotes fibrovascular tissue formation within the implant in vivo. In this study, it is determine to what extent these events can be controlled by changing the physical environment of the implants both in vitro and in vivo. By cell tracking, it is observed that the size of the beads and the distance between the neighboring beads significantly affect the ability of cells to develop cell-to-cell contacts and to bridge the pores. Live cell staining shows that as the bead size gets smaller, the probability to observe cells that fill the porous areas is higher. This also affects the initial attachment and distribution of the cells and collagen secretion by fibroblasts. Obtaining a fast coverage of the system also enables co-culture systems where, the number and the distribution of the second cell type are boosted by the presence of the first. This concept is utilized to increase the attachment of vascular endothelial cells by an initial layer of fibroblasts. By decreasing the bead diameter, the overall colonization of the implant can be significantly increased in vivo. The effect of bead size has a similar pattern both in rats and rabbits, with faster colonization of smaller bead-based structures. Using smaller beads would improve clinical outcomes as faster integration facilitates the attainment of functionality by the implant.

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Tracheal Reconstruction

Abstract: Porous titanium is an inert biomaterial that provides support and allows easy revascularization of a mucosal graft. Titanium, in combination with viable autologous tissues, is a good alternative for tracheal reconstruction.

Cited by 14 publications

References 27 publications

Evaluation of Functionalized Porous Titanium Implants for Enhancing Angiogenesis in Vitro

Evaluation of Functionalized Porous Titanium Implants for Enhancing Angiogenesis in Vitro

A Novel Design of Temporomandibular Joint Prosthesis for Lateral Pterygoid Muscle Attachment: A Preliminary Study

Titanium Microbead‐Based Porous Implants: Bead Size Controls Cell Response and Host Integration

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