Tracheal epithelial cell-exosome-derived MiR-21-5p inhibits alveolar macrophage pyroptosis to resist pulmonary bacterial infection through PIK3CD-autophagy pathway

Wang, Jun; Gan, Lin; Li, Fengyang; Li, Qin; Wu, Tong; Wu, Zengshuai; Chen, Peiru; Scicluna, Brendon P.; Feng, Xin; Gu, Jingmin; Han, Wenyu; Li, Na; Lei, Liancheng

doi:10.1016/j.lfs.2023.122340

Life Sciences

2024

DOI: 10.1016/j.lfs.2023.122340

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Tracheal epithelial cell-exosome-derived MiR-21-5p inhibits alveolar macrophage pyroptosis to resist pulmonary bacterial infection through PIK3CD-autophagy pathway

Jun Wang,

Lin Gan,

Fengyang Li

et al.

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Cited by 2 publications

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The expression patterns of exosomal miRNAs in the Pacific oyster after high-temperature stress or Vibrio stimulation

Liu,

Gao,

Zhou

et al. 2024

Developmental & Comparative Immunology

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The expression patterns of exosomal miRNAs in the Pacific oyster after high-temperature stress or Vibrio stimulation

Liu,

Gao,

Zhou

et al. 2024

Developmental & Comparative Immunology

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Bacterial Programmed Cell Death Induced by Nanotherapeutic Strategies

Hu,

Shao,

Dong

et al. 2024

ACS Materials Lett.

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Programmed cell death (PCD) is crucial for cell renewal, embryogenesis, the immune response, tissue growth regulation, and other essential biological processes. Recent evidence underscores the potential of harnessing PCD to combat bacterial infections, particularly in eradicating antibiotic-resistant superbugs. Extensive efforts have been devoted to developing PCD-mediated anti-infective agents by drawing insights from materials science, chemistry, immunology, and microbiology. In this review, the challenges in addressing bacterial infections and the potential of PCD-based approaches to revolutionize treatment are first summarized and discussed. Then, a comprehensive examination of PCD-mediated nanoantibacterial therapy, encompassing various pathways, such as bacterial apoptosis, ferroptosis, cuproptosis, immunogenic cell death, NETosis, autophagy, and pyroptosis, is provided. Finally, the barriers and prospects of PCD-driven antimicrobial strategies are explored.

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Tracheal epithelial cell-exosome-derived MiR-21-5p inhibits alveolar macrophage pyroptosis to resist pulmonary bacterial infection through PIK3CD-autophagy pathway

Cited by 2 publications

References 45 publications

The expression patterns of exosomal miRNAs in the Pacific oyster after high-temperature stress or Vibrio stimulation

The expression patterns of exosomal miRNAs in the Pacific oyster after high-temperature stress or Vibrio stimulation

Bacterial Programmed Cell Death Induced by Nanotherapeutic Strategies

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