“…2) Based on final anatomic and physiological phenotypes, CHDs have been classified into at least 25 distinctive types, such as ventricular septal defect (VSD), double-orifice mitral valve, atrial septal defect, coronary artery anomaly, patent ductus arteriosus, Ebstein's anomaly, tetralogy of Fallot, double outlet right ventricle (DORV), aortic stenosis, transposition of the great arteries, truncus arteriosus, interrupted aortic arch, coarctation of the aorta, pulmonary stenosis, endocardial cushion defect, hypoplastic left ventricle, and anomalous pulmonary venous connection. 1,[2][3][4][5][6][7][8] Although minor CHDs may resolve spontaneously, 2) severe CHDs require timely intervention in the first year of life and otherwise may give rise to reduced exercise capacity and poor health-related quality of life, [9][10][11] neurodevelopmental anomaly or brain injury, [12][13][14] pulmonary arterial hypertension, [15][16][17][18][19] hemorrhagic or thromboembolic stroke, [20][21][22] dementia, 23) infective endocarditis, [18][19][20][21][22][23][24][25][26][27][28][29][30] myocardial infarction, 31,32) myocardial fibrosis, [33][34]…”