Tracers Applied in Radioguided Surgery

Bunschoten, Anton; Berg, Nynke S. van den; Olmos, Renato A. Valdés; Blokland, J. A. K.; Leeuwen, F.W.B. van

doi:10.1007/978-3-319-26051-8_5

Cited by 10 publications

(10 citation statements)

References 133 publications

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“…Unfortunately, radiation dose to the patient does increase. fhSPECT navigation + Ultrasound (Percutaneous interventions) 100,113,114,116,119,120,130,150,156,157,179,[186][187][188]191,[194][195][196]198,199,212,216,220,221,244,245,254] Radioguided occult lesion localization (ROLL) Pulmonary lesions (e.g. lung cancer), thyroid cancer, endometriosis, renal cancer, ovary cancer, colorectal In the evolution of surgical techniques, more and more minimally invasive alternatives are being pursued, of which (robot-assisted) laparoscopic surgery is a prime example [112].…”

Section: Article Highlightsmentioning

confidence: 99%

“…A combination of factors still makes this kind of nuclear detection dominant during surgery: (1) a clear connection to preoperative total body molecular imaging (i.e. SPECT/CT) available, (2) in-depth information offered for lesion localization and confirmation, (3) ease of use due to low sample times (<1 s) and plurality of form factors possible with relative lightweight and small dimensions, and (4) a relative low dose to patient and surgical staff [254].…”

Section: Five-year Viewmentioning

confidence: 99%

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Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

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Introduction: Radioguided surgery is an ever-evolving part of nuclear medicine. In fact, this nuclear medicine sub-discipline actively bridges non-invasive molecular imaging with surgical care. Next to relying on the availability of radio-and bimodal-tracers, the success of radioguided surgery is for a large part dependent on the imaging modalities and imaging concepts available for the surgical setting. With this review, we have aimed to provide a comprehensive update of the most recent advances in the field. Areas covered: We have made an attempt to cover all aspects of radioguided surgery: 1) the use of radioisotopes that emit γ, β + , and/or β − radiation, 2) hardware developments ranging from probes to 2D cameras and even the use of advanced 3D interventional imaging solutions, and 3) multiplexing solutions such as dual-isotope detection or combined radionuclear and optical detection. Expert opinion: Technical refinements in the field of radioguided surgery should continue to focus on supporting its implementation in the increasingly complex minimally invasive surgical setting, e.g. by accommodating robot-assisted laparoscopic surgery. In addition, hybrid concepts that integrate the use of radioisotopes with other image-guided surgery modalities such as fluorescence or ultrasound are likely to expand in the future.

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Section: Article Highlightsmentioning

confidence: 99%

Section: Five-year Viewmentioning

confidence: 99%

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

View full text Add to dashboard Cite

show abstract

“…Alternatively, Costa et al have used ex vivo Cerenkov imaging to identify 68 Ga-PSMA-11 uptake in prostate sections containing primary PCa lesions. Despite the potential displayed by these technologies, the half-life of 68 Ga ( t 1/2, rad = 1.1 h) limits the surgical time frame, the radiation dose to the surgical staff is potentially high, , and renal clearance of 68 Ga-PSMA-11 (kidney retention 139.4 ± 21.4%ID/g at 1 h) means that prostate samples need to be rinsed prior to imaging to remove urine contamination. Furthermore, the signal penetration of β + -emissions (mm range) and the resulting Cerenkov luminescence (<2 mm) limits the implementation to superficial lesions.…”

Section: Psma-targeted Tracersmentioning

confidence: 99%

Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers?

et al. 2019

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Expressed on virtually all prostate cancers and their metastases, the transmembrane protein prostate-specific membrane antigen (PSMA) provides a valuable target for the imaging of prostate cancer. Not only does PSMA provide a target for noninvasive diagnostic imaging, e.g., PSMA-positron emission tomography (PSMA–PET), it can also be used to guide surgical resections of PSMA-positive lesions. The latter characteristic has led to the development of a plethora of PSMA-targeted tracers, i.e., radiolabeled, fluorescent, or hybrid. With image-guided surgery applications in mind, this review discusses these compounds based on clinical need. Here, the focus is on the chemical aspects (e.g., imaging label, spacer moiety, and targeting vector) and their impact on in vitro and in vivo tracer characteristics (e.g., affinity, tumor uptake, and clearance pattern).

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“…While no specific OSCC data exist, for the 99m Tc-based radiocolloids, when applied at the same or a similar activity, the radiation risk associated with this procedure is low [45]. This may, however, change when radiocolloids are used that have, for example, 89 Zr as radiolabel [46, 47]. …”

Section: Dosimetry and Radiation Protectionmentioning

confidence: 99%

The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma

Giammarile

Schilling

Gnanasegaran

et al. 2018

Eur J Nucl Med Mol Imaging

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PurposeSentinel lymph node biopsy is an essential staging tool in patients with clinically localized oral cavity squamous cell carcinoma. The harvesting of a sentinel lymph node entails a sequence of procedures with participation of specialists in nuclear medicine, radiology, surgery, and pathology. The aim of this document is to provide guidelines for nuclear medicine physicians performing lymphoscintigraphy for sentinel lymph node detection in patients with early N0 oral cavity squamous cell carcinoma.MethodsThese practice guidelines were written and have been approved by the European Association of Nuclear Medicine (EANM) and the International Atomic Energy Agency (IAEA) to promote high-quality lymphoscintigraphy. The final result has been discussed by distinguished experts from the EANM Oncology Committee, and national nuclear medicine societies. The document has been endorsed by the Society of Nuclear Medicine and Molecular Imaging (SNMMI).These guidelines, together with another two focused on Surgery and Pathology (and published in specialised journals), are part of the synergistic efforts developed in preparation for the “2018 Sentinel Node Biopsy in Head and Neck Consensus Conference”.ConclusionThe present practice guidelines will help nuclear medicine practitioners play their essential role in providing high-quality lymphatic mapping for the care of early N0 oral cavity squamous cell carcinoma patients.

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Tracers Applied in Radioguided Surgery

Cited by 10 publications

References 133 publications

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers?

The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma

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