Traceability of pulsed flow rates consisting of constant delivered volumes at given time interval

Bissig, Hugo; Tschannen, Martin; Huu, M.A. de

doi:10.1016/j.flowmeasinst.2020.101729

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…The accuracy of bolus and basal rate delivery, in nominal conditions, showed globally good results in agreement with the manufacturers' specifications [16,17]. Larger deviations are observed at short observation windows (typically less than 1h in basal rate), due to the inherent noise induced by the pumping engine itself and the so-called stick-slip effect of the piston against the internal wall of the insulin container [18][19][20]. Other insulin pump designs have been studied to improve short-term variability of insulin delivery and shorten occlusion detection time [21][22][23][24].…”

Section: Introductionsupporting

confidence: 69%

Displacement Micropump with Check Valves for Diabetes Care—The Challenge of Pumping Insulin at Negative Pressure

Chappel

2024

Encyclopedia

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The displacement micropump with passive check valves is an attractive solution for precise insulin infusion in patients with type I diabetes. Unlike most insulin pumps that push insulin from a cartridge using a piston, a displacement micropump will first pull insulin from the reservoir before infusing it into the patient. This dual sequence introduces new challenges in terms of insulin stability, notably if the reservoir is not pressurized. After an introduction to displacement micropumps and a brief review of the insulin degradation mechanism, micropump design rules are discussed in light of microfluidic theory.

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Section: Introductionsupporting

confidence: 69%

Displacement Micropump with Check Valves for Diabetes Care—The Challenge of Pumping Insulin at Negative Pressure

Chappel

2024

Encyclopedia

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“…Depending on the basal rate (insulin flow rate), the volume of the single dose and the time interval between single doses (i.e., the cycle time) are varying as we will show later in this paper. Several authors report on gravimetric [2,4,5] or optical methods [6,7] to analyse the so-called dose-to-dose accuracy for clinically relevant periods of time.…”

Section: Introductionmentioning

confidence: 99%

Calibration of insulin pumps based on discrete doses at given cycle times

Bissig

Büker

Stolt

et al. 2022

Biomedical Engineering / Biomedizinische Technik

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One application in the medical treatment at very small flow rates is the usage of an Insulin pump that delivers doses of insulin at constant cycle times for a specific basal rate as quasi-continuous insulin delivery, which is an important cornerstone in diabetes management. The calibration of these basal rates are performed by either gravimetric or optical methods, which have been developed within the European Metrology Program for Innovation and Research (EMPIR) Joint Research Project (JRP) 18HLT08 Metrology for drug delivery II (MeDDII). These measurement techniques are described in this paper, and an improved approach of the analytical procedure given in the standard IEC 60601-2-24:2012 for determining the discrete doses and the corresponding basal rates is discussed in detail. These improvements allow detailed follow up of dose cycle time and delivered doses as a function of time to identify some artefacts of the measurement method or malfunctioning of the insulin pump. Moreover, the calibration results of different basal rates and bolus deliveries for the gravimetric and the optical methods are also presented. Some analysis issues that should be addressed to prevent misinterpreting of the calibration results are discussed. One of the main issues is the average over a period of time which is an integer multiple of the cycle time to determine the basal rate with the analytical methods described in this paper.

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