Trace minerals in experimental subarachnoid haemorrhage: zinc, copper and manganese levels in rat brain tissue, blood and urine

Cosan, T. Erhan; Demir, Temir Ali; Yayla, Elif; Coşan, Didem Turgut; Berber, Asiye; Kaynak, Zerrin

doi:10.1007/s00701-006-0745-1

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…Calibration was performed using manganese aqueous standards prepared in 5% nitric acid from a commercial standard solution (Perkin-Elmer Pure AS Standard). The calibration curve for Mn was linear over the range from 1–200 μg/L, and the mean Mn concentration determined from vehicle control samples (0.44 ± 0.09 ppm) was comparable to a published precedent (Cosan et al, 2006). …”

Section: Methodssupporting

confidence: 82%

In Vivo Imaging with a Cell-Permeable Porphyrin-Based MRI Contrast Agent

Lee

Zhang

Dhar

et al. 2010

Chemistry & Biology

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SUMMARY Magnetic resonance imaging (MRI) with molecular probes offers the potential to monitor physiological parameters with comparatively high spatial and temporal resolution in living subjects. For detection of intracellular analytes, construction of cell-permeable imaging agents remains a challenge. Here we show that a porphyrin-based MRI molecular imaging agent, Mn-(DPA-C2)2-TPPS3, effectively penetrates cells and persistently stains living brain tissue in intracranially injected rats. Chromogenicity of the probe permitted direct visualization of its distribution by histology, in addition to MRI. Distribution was concentrated in cell bodies after hippocampal infusion. Mn-(DPA-C2)2-TPPS3 was designed to sense zinc ions, and contrast enhancement was more pronounced in the hippocampus, a zinc-rich brain region, than in the caudate nucleus, which contains relatively little labile Zn2+. Membrane permeability, optical activity, and high relaxivity of porphyrin-based contrast agents offer exceptional functionality for in vivo imaging.

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Section: Methodssupporting

confidence: 82%

In Vivo Imaging with a Cell-Permeable Porphyrin-Based MRI Contrast Agent

Lee

Zhang

Dhar

et al. 2010

Chemistry & Biology

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“…For instance, Cu blood concentrations increase dramatically in many conditions including metabolic defects, such as Menkes syndrome and Wilson disease [47][48][49], pregnancy [50], and inflammation [51]. Blood Mn levels were also found to decrease in experimental subarachnoid hemorrhage [52]. This is the first evidence that Cu and Mn status were affected in experimental SOX deficiency.…”

Section: Discussionmentioning

confidence: 94%

Ceruloplasmin, Copper, Selenium, Iron, Zinc, and Manganese Levels in Normal and Sulfite Oxidase Deficient Rat Plasma: Effects of Sulfite Exposure

Herken

Kocamaz

Kucukatay

et al. 2008

Biol Trace Elem Res

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A noticeable effect of sulfite treatment was observed on the plasma ceruloplasmin ferroxidase activity of rats with normal sulfite oxidase activity when compared to normal controls. The plasma levels of selenium, iron, and zinc were unaffected by sulfite in normal and sulfite oxidase (SOX)-deficient rats. While plasma level of Mn was decreasing, plasma Cu level increased in SOX-deficient rats. Treating SOX-deficient groups with sulfite did not alter plasma level of Mn but made plasma level of Cu back to its normal level. This is the first evidence that Cu and Mn status were affected in experimental sulfite oxidase deficiency induced by low molybdenum diet with tungsten addition deserving further research to determine the underlying mechanisms of these observations in experimental sulfite oxidase deficiency.

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“…Both copper and zinc act as antioxidants mainly through their associated enzyme Cu, Zn superoxide dismutase and ceruloplasmin. Zn and Cu containing superoxide dismutase have been much reported in the literature and are important to antioxidant defense and catalyze the conversion of two O 2 -to O 2 and H 2 O 2 in the cytosol [9]. Thus, it is clear that Cu and Zn play an important role in the development of oxidative stress.…”

Section: Discussionmentioning

confidence: 98%

“…These were then cleaned with distilled water and dried in an oven overnight at 100°C [9]. The tissue samples were weighed and transferred into metal-free glass tubes for digestion.…”

Section: Measurements Of Trace Elementsmentioning

confidence: 99%

The Effect of β-Glucan on Trace Element Levels in Intra-Abdominal Sepsis in Rats

Özdemir

Toplan

Ercan

et al. 2009

Biol Trace Elem Res

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Sepsis is associated with the development of progressive damage in multiple organ systems. The beneficial effect of glucans has been attributed to modulation of immune function and enhances defense against bacterial, viral, fungal, and parasitic infections. The aim of this study was to investigate the putative protective effect of ß-glucan on changes of trace element levels in various tissues after experimental sepsis in rats. Sepsis was induced by cecal ligation and perforation (CLP) in 28 male Wistar albino rats. To evaluate this, rats were divided into four groups as sham operated, ß-glucan treated sham operated, CLP, and ß-glucan treated CLP. Sixteen hours after operation, rats were decapitated and zinc (Zn) and copper (Cu) levels were determined in the liver, kidney, heart, diaphragm, and lung tissues. The results demonstrate that sepsis significantly decreased zinc and copper levels of all tissues. The decrease in tissue zinc and copper levels demonstrates the role of trace elements in sepsis-induced tissue damage. Our results indicated that ß-glucan administration did not return the zinc and copper levels to the control group level, and it seems likely that the given dose of ß-glucan was insufficient to prevent sepsis-induced organ injury.

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Trace minerals in experimental subarachnoid haemorrhage: zinc, copper and manganese levels in rat brain tissue, blood and urine

Cited by 8 publications

References 26 publications

In Vivo Imaging with a Cell-Permeable Porphyrin-Based MRI Contrast Agent

In Vivo Imaging with a Cell-Permeable Porphyrin-Based MRI Contrast Agent

Ceruloplasmin, Copper, Selenium, Iron, Zinc, and Manganese Levels in Normal and Sulfite Oxidase Deficient Rat Plasma: Effects of Sulfite Exposure

The Effect of β-Glucan on Trace Element Levels in Intra-Abdominal Sepsis in Rats

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