Trace metals in blood and urine of newborn/mother pairs, adolescents and adults of the Flemish population (2007–2011)

Baeyens, Willy; Vrijens, Jan; Gao, Yue; Croes, Kim; Schoeters, Greet; Hond, Elly Den; Sioen, Isabelle; Bruckers, Liesbeth; Nawrot, Tim S.; Nelen, Vera; Mieroop, Els Van Den; Morrens, Bert; Loots, Ilse; Larebeke, N. Van; Leermakers, Martine

doi:10.1016/j.ijheh.2014.06.007

Cited by 62 publications

(44 citation statements)

References 54 publications

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“…HBM surveys in Flanders (2007Flanders ( -2011 identified regional differences in urinary cadmium and toxic arsenic in industrial hot-spot areas, which could be related to socio-economic factors and were used to trigger preventive policies (Vrijens et al, 2014).…”

Section: Methods Of Quantificationmentioning

confidence: 99%

“…However, Flanders' FLEHS, France's ENNS, Canada's CHMS and USA's NHANES have measured different species of arsenic such as inorganic As(III), As(V), MMA, DMA as well as organic arsenobetaine, arsenocholine, and trimethylarsine oxide. In the FLEHS study, it was observed that levels of inorganic arsenic (more toxic form) were higher in participants living near an industrial plant than control participants (Vrijens et al, 2014).…”

Section: Analysed Substances and Substance Groupsmentioning

confidence: 96%

“…For example, it was observed from the French ELFE study that pregnant women have a significant exposure to phthalates, reflecting a potential high exposure in the hospitals (Zeman et al, 2013), and findings from the South Korean MOCEH study suggested that prenatal exposure to phthalates may be inversely associated with the neurodevelopment of infants (Kim et al, 2011b). In the Flanders' FLEHS study, a strong correlation for Pb, As, and Tl was found between levels in cord blood and maternal blood, suggesting that these metals are transported to the fetus from the mother (Baeyens et al, 2014), and it appears that prenatal exposure to metals have adverse effects on newborns. The MOCEH study indicated a negative relationship between maternal Pd and Cd levels during late pregnancy period and neurodevelopment (Kim et al, 2013b).…”

Section: Pregnant Women and Newbornsmentioning

confidence: 99%

“…but also areas with elevated fish consumers or with high pollutant levels detected in home-grown vegetables or drinking water (Schoeters et al, 2012a). For example, significant correlations between fish consumption and arsenic concentrations in the urine samples of both adolescents and adults have been made from the FLEHS results (Baeyens et al, 2014).…”

Section: Investigation Of Exposure Sourcesmentioning

confidence: 99%

“…Communication to participants/scientific community/public: The results have been published (Vrijens et al, 2014). In addition, personal results were communicated to the participants after analysis Review of HBM and its application to exposure assessment for food safety EFSA supporting publication 2015:EN-724 60…”

Section: Reference Valuesmentioning

confidence: 99%

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Review of the state of the art of human biomonitoring for chemical substances and its application to human exposure assessment for food safety

Choi¹,

Mørck²,

Polcher³

et al. 2015

EFS3

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Human biomonitoring (HBM) measures the levels of substances in body fluids and tissues. Many countries have conducted HBM studies, yet little is known about its application towards chemical risk assessment, particularly in relation to food safety. Therefore a literature search was performed in several databases and conference proceedings for 2002 -2014. Definitions of HBM and biomarkers, HBM techniques and requirements, and the possible application to the different steps of risk assessment were described. The usefulness of HBM for exposure assessment of chemical substances from food source, and for the implementation of a systematic Post Market Monitoring (PMM) approach for regulated chemical substances was evaluated. An inventory of HBM programmes provides detailed information about study design, analytical methods, reference values (RV) and biomarkers used. Environmental monitoring and associations between HBM values and food, as well as coverage of substances and remaining deficits are highlighted. The review of study results provides information on emerging chemicals, higher exposed and particularly vulnerable populations.Conclusions: HBM can bring added value for chemical risk assessment in food safety areas (namely exposure assessment), and for the implementation of a systematic PMM approach. But further work needs to be done to improve usability. Major deficits are the lack of HBM guidance values on a considerable number of substance groups, for which health based guidance values (HBGVs) have been developed, insufficient knowledge regarding exposure sources, and incomplete dietary intake assessment. Recommendations: We recommend to foster development of HBM based guidance values and validated analytical methods/BMs, stronger inclusion of substances of interest for EFSA in European surveys, expanded monitoring of highly exposed and vulnerable subgroups, uptake of EFSA guidance concerning dietary intake assessment, as well as biobanking, surveillance synergies and targeted research, and an EU wide collaborative approach to support the future use of HBM in PMM.©BiPRO GmbH, 2015 DISCLAIMERThe present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors. The present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded foll...

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Section: Methods Of Quantificationmentioning

confidence: 99%

Section: Analysed Substances and Substance Groupsmentioning

confidence: 96%

Section: Pregnant Women and Newbornsmentioning

confidence: 99%

Section: Investigation Of Exposure Sourcesmentioning

confidence: 99%

Section: Reference Valuesmentioning

confidence: 99%

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Review of the state of the art of human biomonitoring for chemical substances and its application to human exposure assessment for food safety

Choi¹,

Mørck²,

Polcher³

et al. 2015

EFS3

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Exposure and Risk Assessment of Hg, Cd, As, Tl, Se, and Mo in Women of Reproductive Age Using Urinary Biomonitoring

Coscollà

Sánchez²,

Corpas-Burgos

et al. 2021

Enviro Toxic and Chemistry

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The present study analyzed the exposure and risk assessment of 4 toxic (Hg, Cd, As, Tl) and 2 essential (Se, Mo) elements in 119 Spanish women of reproductive age. The focus was on the elements for which risk‐based benchmark, biomonitoring equivalents, or health‐related human biomonitoring values have already been established. All elements presented frequencies of detection of 100% (greater than the limit of detection), except for Cd (99%). The 95th percentile concentrations were, for the toxic metals, 358.37 µg/L (total As), 1.10 µg/L (Cd), 0.41 µg/L (Tl), and 3.03 µg/L (total Hg) and, for the essential elements, 68.95 µg/L (total Se) and 154.67 (Mo). We examined sociodemographic factors and dietary habits of women as predictors of urinary metal concentrations. Arsenic was positively associated with fish, shellfish, and canned fish consumption, whereas Mo was found to be associated with the consumption of cereals and pastry products. Maternal urine levels of As were negatively correlated with gestational age. In a risk‐assessment context, hazard quotients (HQs) using the 95th percentile ranged from 0.08 (Tl) to 15.1 (urinary speciated As), with Cd presenting an HQ of 1.1 (95th percentile). None of the essential metals presented concentrations higher than their upper intake level; however, 3% of the mothers showed lower levels of Se than the estimated average requirement (EAR) biomonitoring equivalent, and 20% of the mothers were found to have lower levels of Mo than the EAR biomonitoring equivalent, suggesting a nutritionally inadequate diet. Environ Toxicol Chem 2021;40:1477–1490. © 2021 SETAC

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Transplacental exposure to carcinogens and risks to children: evidence from biomarker studies and the utility of omic profiling

Botsivali

Kyrtopoulos

2019

Arch Toxicol

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Trace metals in blood and urine of newborn/mother pairs, adolescents and adults of the Flemish population (2007–2011)

Cited by 62 publications

References 54 publications

Review of the state of the art of human biomonitoring for chemical substances and its application to human exposure assessment for food safety

Review of the state of the art of human biomonitoring for chemical substances and its application to human exposure assessment for food safety

Exposure and Risk Assessment of Hg, Cd, As, Tl, Se, and Mo in Women of Reproductive Age Using Urinary Biomonitoring

Transplacental exposure to carcinogens and risks to children: evidence from biomarker studies and the utility of omic profiling

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