Trace Level Recognition of Zn²⁺ and Cd²⁺ by Biocompatible Chemosensor inside Androecium, Diagnosis of Pick’s Disease from Urine and Biomimetic β-Cell Exocytosis

Abstract

Two chemosensors with varying substitution have been synthesized for selective detection of d10 metal ion analyte Zn2+ and Cd2+ by fluorometric method from aqueous medium at very low limit of detection. Density functional theory (DFT)-based Loewdin spin population analysis reveals that methoxy-substituted chemosensor is much stronger donor than bromo-substituted chemosensor. Eventually, bromo and methoxy substituted chemosensors are moderate and strong donor, respectively, toward selective detection of Cd2+ and Zn2+ by luminescence induced phenomenon (blue for Cd2+ and cyan for Zn2+). The mechanism of sensing could be explained by PET-CHEF-C = N isomerization-ILCT pathway. 1H NMR, ESI-MS and FT-IR has been carried out in order to explore the selective ion sensing mechanism. Intracellular detection of Zn2+ and Cd2+ has been carried out inside androecium (filament and pollens) of Tecoma Stans. Extracellular detection of Zn2+ for yeast cells represents the bio mimetic model experiments toward β-cells exocytosis as a marker of diabetes mellitus. The unprecedented and novel feature of the present biocompatible chemosensor is its application as biosensor to detect in vivo Zn2+ from human urine specimen which could be a next generation diagnostic tool for Pick’s disease.

Solvent-Regulated Fluorimetric Differentiation of Al3+ and Zn2+ Using an AIE-Active Single Sensor

“…However, a prominent change in fluorescence occurred after the addition of Zn 2+ centered near 527 nm (Figure b). H 2 L could clearly distinguish Zn 2+ from other metal ions and also from Cd 2+ by emission intensities, although discrimination of zinc from cadmium is a huge challenging task due to their similar physical properties. , With a gradual addition of Zn 2+ to H 2 L , a strong emission band at nearly 527 nm, ∼10-fold enhancement of the red-shifting emission (Δλ = 18 nm) (from 509 to 527 nm), was observed with deepening of greenish color (Figure c). No further changes of the emission intensity of the system were noticed above 2.5 equiv (50 μM) Zn 2+ ions.…”

A novel dihydro phenylquinazolinone-based two-in-one colourimetric chemosensor for nickel(ii), copper(ii) and its copper complex for the fluorescent colourimetric nanomolar detection of the cyanide anion

“…Cu is the 3rd most important trace element, aer Fe and Zn in various biological metabolic processes. [12][13][14] The free copper commonly found in water is potentially toxic to living organisms and the ecosystem. A high concentration of copper in the body for a short period can cause various serious diseases such as amyotrophic lateral sclerosis, 15 Alzheimer's disease, 16 Parkinson's disease, 17 Wilson's disease 18 and Menkes syndrome.…”

Dynamics of Transition Metal and their Application in Biomedical Industry

“…It is coordinated to the Co (II) ion through its carboxylato oxygen atom, forming octahedral [Co(mef) 2 (MeOH) 4 ] or [Co(mef) 2 (MeOH) 2 (N^N)] (where mef = mefenamic acid and N^N = 2,2′-bipyridine, 1,10-phenanthroline or (pyridine) 2 ) complexes which is in accordance with the physicochemical and spectroscopic data. In later studies, Cu(II) complexes of mefenamic acid, naproxen, diclofenac, diflunisal and flufenamic acid, Co (II) complexes of naproxen and tolfenamic acid, and Mn (II) complexes of tolfenamic acid have been reported by the researchers that showed antiinflammatory activity [53].…”