Trace level determination of eleven nervous system–active pharmaceutical ingredients by switchable solvent-based liquid-phase microextraction and gas chromatography–mass spectrometry with matrix matching calibration strategy

Bozyiğit, Gamze Dalgıç; Ayyıldız, Merve Fırat; Chormey, Dotse Selali; Engin, Güleda Önkal; Bakırdere, Sezgin

doi:10.1007/s10661-021-09708-5

Cited by 7 publications

(2 citation statements)

References 40 publications

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“…Gas chromatography (GC) is a separation and analysis technique with high sensitivity and selectivity, and widely used in petrochemical, [1] environmental, [2] food, [3] pharmaceutical [4] and biological analysis [5] . The research on the developing highly selective stationary phases is the main content to work out the issues for separating complex samples in GC.…”

Section: Introductionmentioning

confidence: 99%

High‐Resolution Performance of Polycaprolactone Functionalized with Guanidinium Ionic Liquid for Gas Chromatography

Chi

Chen

et al. 2023

Chemistry & Biodiversity

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This work firstly reported a new polycaprolactone based material functionalized with guanidinium ionic liquid (PCL‐GIL) as the stationary phase with high resolution performance for capillary gas chromatography (GC). It is composed of polycaprolactone (PCL) and guanidinium ionic liquid (GIL) with amphiphilic conformation. The PCL‐GIL capillary column coated by static method exhibited high column efficiency of 3942 plates/m and moderate polarity. As a result, the PCL‐GIL column exhibited high‐resolution capability. For a mixture of 27 analytes with a wide ranging polarity and outperformed the PCL‐2OH and HP‐35 columns, showing its advantageous separation capability for analytes of diverse types. Moreover, the PCL‐GIL column showed high resolving capability for various positional isomers and cis‐/trans‐isomers, including alkylbenzenes, chlorobenzenes, naphthalenes, bromonitrobenzenes, chloronitrobenzenes, benzaldehydes, phenols, alcohols, respectively. In a word, PCL derivatized by GIL units as a new type of stationary phase has a promising future in GC separations.

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Section: Introductionmentioning

confidence: 99%

High‐Resolution Performance of Polycaprolactone Functionalized with Guanidinium Ionic Liquid for Gas Chromatography

Chi

Chen

et al. 2023

Chemistry & Biodiversity

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“…The most frequently used analytical techniques to determine trace levels of pharmaceuticals in water are high performance liquid chromatography coupled with ultraviolet detection (HPLC-UV) [ 51 ] or mass spectrometry (HPLC-MS) [ 5 ], as well as gas chromatography-mass spectrometry (GC-MS) [ 52 ]. Due to the polar, non-volatile, and thermally unstable nature of pharmaceuticals, LC-MS and LC-MS/MS are frequently used to analyze them in aqueous samples [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

A Fully Automated Online SPE-LC-MS/MS Method for the Determination of 10 Pharmaceuticals in Wastewater Samples

Belay

Precht

Mortensen

et al. 2022

Toxics

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The increasing use of pharmaceuticals, their presence in the aquatic environment, and the associated toxic effects, have raised concerns in recent years. In this work, a new multi-residue analytical method was developed and validated for the determination of 10 pharmaceuticals in wastewaters using online solid-phase extraction (online SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). The compounds included in the method were antineoplastics (cabazitaxel, docetaxel, doxorubicin, etoposide, irinotecan, methotrexate, paclitaxel, and topotecan), renin inhibitors (aliskiren), and antidepressants (maprotiline). The method was developed through several experiments on four online SPE cartridges, three reversed phase chromatography columns, and four combinations of mobile phase components. Under optimal conditions, very low limits of detection (LODs) of 1.30 to 10.6 ng L−1 were obtained. The method was repeatable, with relative standard deviations (RSD, %) for intraday and interday precisions ranged from 1.6 to 7.8 and from 3.3 to 13.2, respectively. Recovery values ranged from 78.4 to 111.4%, indicating the reproducibility of the method. Matrix effects were mainly presented as signal suppression, with topotecan and doxorubicin being the two most affected compounds (31.0% signal suppression). The proposed method was successfully applied to hospital effluents, detecting methotrexate (4.7–9.3 ng L−1) and maprotiline (11.2–23.1 ng L−1). Due to the shorter overall run time of 15 min, including sample preparation, and reduced sample volume (0.9 mL), this on-line SPE-LC-MS/MS method was extremely convenient and efficient in comparison to the classical off-line SPE method. The proposed method was also highly sensitive and can be used for ultratrace quantification of the studied pharmaceuticals in wastewaters, providing useful data for effective environmental monitoring.

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Polystyrene‐Coated Magnetite Nanoparticles Based Dispersive Micro‐Solid Phase Extraction of Active Pharmaceutical Ingredients of Antidepressant Drugs and Determination by GC‐MS

et al. 2022

Self Cite

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A dispersive micro-solid phase extraction (D-μ-SPE) method based on polystyrene coated magnetic nanoparticles (PS@MNPs) was used to preconcentrate the active ingredients of three antidepressant drugs from aqueous solution to be determined by gas chromatography mass spectrometry. Eight prominent parameters of the D-μ-SPE method were optimized univariately to boost the recovery and extraction efficiency of the analytes. The three analytes recorded very low detection limits between 0.40 and 0.60 ng/mL, and the dynamic range was broad with high linearity. Medical wastewater was selected as test sample to evaluate the method's applicability and accuracy, and the percent recovery results obtained ranged between 90 and 98 % for two different spike concentrations. The proximity of the recovery results to 100 % and the low standard deviations validated the developed method's accuracy and precision, respectively.

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Trace level determination of eleven nervous system–active pharmaceutical ingredients by switchable solvent-based liquid-phase microextraction and gas chromatography–mass spectrometry with matrix matching calibration strategy

Cited by 7 publications

References 40 publications

High‐Resolution Performance of Polycaprolactone Functionalized with Guanidinium Ionic Liquid for Gas Chromatography

High‐Resolution Performance of Polycaprolactone Functionalized with Guanidinium Ionic Liquid for Gas Chromatography

A Fully Automated Online SPE-LC-MS/MS Method for the Determination of 10 Pharmaceuticals in Wastewater Samples

Polystyrene‐Coated Magnetite Nanoparticles Based Dispersive Micro‐Solid Phase Extraction of Active Pharmaceutical Ingredients of Antidepressant Drugs and Determination by GC‐MS

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