Trace Elements Profile among Alcohol Abusers in a Nigerian Community

Stanley, PC; Okeke, Edith; Ukoli, Christian

doi:10.4314/jasem.v11i1.46832

Cited by 3 publications

(3 citation statements)

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“…The drinking of alcohol was not statistically associated with blood Cu concentration. Some literature studies did not find differences between drinkers and abstainers [37], others noted a relationship between Cu blood levels and consumption of wine [38]. This metal has been found in wine as a residue of the Cu-based pesticide treatment of grapes and the migration from containers [39].…”

Section: Discussionmentioning

confidence: 99%

Assessment of reference ranges for blood Cu, Mn, Se and Zn in a selected Italian population

Bocca

Madeddu

Asara

et al. 2011

Journal of Trace Elements in Medicine and Biology

100

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Section: Discussionmentioning

confidence: 99%

Assessment of reference ranges for blood Cu, Mn, Se and Zn in a selected Italian population

Bocca

Madeddu

Asara

et al. 2011

Journal of Trace Elements in Medicine and Biology

100

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“…Evidence has implied the influence of these exposures onto the concentration of trace elements. Different levels of physical activity (68) weight category (38,69), smoking status (70), alcohol consumption (71) and diet (72,73) were reported to also influence the concentrations. Therefore, there is a need to look more specifically into environmental exposures, which are likely to disclose changes in the level of the elements.…”

Section: Future Direction Of Trace Elements Study and Crcmentioning

confidence: 99%

Tissue and Serum Trace Elements Concentration among Colorectal Patients: A Systematic Review of Case-Control Studies

Nawi¹,

Chin²,

Shah³

et al. 2019

ijph

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Background: Trace elements play a pivotal role in Colorectal Cancer (CRC) inhibition and development process. This systematic review provides the basic comparison of case-control studies focusing on concentration of trace elements between those with CRC and controls Methods: The systematic review searched through two databases of Medline and Cochrane up to 24th June 2017. The search strategy focused on Population, Intervention, Comparison, and Outcomes (PICO). We searched the role of trace elements in cancer and focusing on case-control studies in CRC to obtain an insight into the differences in trace element concentrations between those with and without cancer. Results: The serum concentrations of Ca, Cu, Mg, Mn, Se, Si, and Zn were lower in CRC patients but for Co and S the levels were higher in CRC patients. The concentrations of Cd, Cr, Cu, Mg, Mn, Pb, and Zn were increased in patients with metastasis, but not in Se. As for colon tissue specimens, inconsistent levels were reported between studies, notably in Cu, Se, and Zn. No changes were reported for B and Ca levels. Most of the trace elements in the tissue specimens showed higher concentrations of Cr, Fe, K, Mg, P, Rb, S, and Si compared to Br. Conclusion: With the growing interest to understand the link between trace elements in carcinogenesis and the possible interactions, multi assessment analysis of a larger cohort of samples is necessary.

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“…Previous research has shown that ADS patients are predisposed to Zinc (hypozincemia) and magnesium (hypomagnesemia) deficiencies [ 16 - 21 ]. This was attributed to various reasons that include alcohol-induced diuresis (excessive urination) and liver failure resulting in abnormal absorption and transport, among others [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

The Activities of Zinc and Magnesium Among Alcohol Dependence Syndrome Patients: A Case-Control Study From a Tertiary Care Teaching Hospital in South India

Pavuluri¹,

Jangili²,

Ryakam³

et al. 2022

Cureus

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Introduction Alcohol dependence syndrome (ADS) is a medical condition characterized by regular and excessive consumption of alcohol. ADS is a brain disorder wherein people consume alcohol despite knowing the physical, social, and financial consequences. Zinc and magnesium are microelements that are essential in the proper functioning of human physiological and biological processes. However, the homeostasis of these microelements' is disturbed among ADS patients. The present study aims to assess Zinc and magnesium activities among ADS patients and age-matched controls. Methods The study included 100 ADS patients and an equal number of the control group and was conducted between August and September 2021. The study was performed after acquiring approval from the institutional ethics committee. All the study cases were patients attending the department of Psychiatry, RVM Institute of Medical Sciences & Research Centre who were diagnosed with ADS. Both groups used the colorimetric method on ERBA Chem 5+ semi autoanalyzer to estimate serum zinc and magnesium levels. Results Among the 100 cases of ADS, 84 (84%) were males, and 16 (16%) were females. Patients were between the age group of 20 and 68 (mean: 42.8 years). Of the 100 controls, 84 (84%) were males, and 16 (16%) were females with a mean age of 43.1 years. The activities of Zinc among ADS patients and the control group were 88.53±18.7 μg/dL and 144.9±38.47 μg/dL (p<0.0001), respectively. The activities of magnesium among the ADS patients and the control group were 1.96±0.46 mg/dL and 2.88±0.4 mg/dL (p<0.0001), respectively. Conclusions The activities of Zinc and magnesium have been noted to be significantly lower among ADS patients. Because both these microelements play a vital role in human cells' metabolic and physiologic activities, therapeutic interventions to compensate for such deficiencies while managing ADS patients may prove beneficial.

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Trace Elements Profile among Alcohol Abusers in a Nigerian Community

Cited by 3 publications

References 1 publication

Assessment of reference ranges for blood Cu, Mn, Se and Zn in a selected Italian population

Assessment of reference ranges for blood Cu, Mn, Se and Zn in a selected Italian population

Tissue and Serum Trace Elements Concentration among Colorectal Patients: A Systematic Review of Case-Control Studies

The Activities of Zinc and Magnesium Among Alcohol Dependence Syndrome Patients: A Case-Control Study From a Tertiary Care Teaching Hospital in South India

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