Trace elements in renal disease and hemodialysis

Miura, Yoshinori; Nakai, Keiko; Suwabe, Akira; Sera, K.

doi:10.1016/s0168-583x(01)01122-3

Cited by 24 publications

(20 citation statements)

References 19 publications

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“…Mayer et al, found decreased arsenic levels in 85 patients who were suffering from renal failure and undergoing haemodialysis treatment [22]. Higher arsenic (As) concentrations have been reported in the blood and bone marrow of patients with renal failure [23,24]. In healthy subjects, arsenic is usually excreted in urine and it is removed to a certain extent by haemodialysis; however, the removal of arsenic by haemodialysis may not be sufficient, thus leading to its accumulation in the body of haemodialysis patients [25][26][27].…”

Section: Resultsmentioning

confidence: 99%

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Palaneeswari

Pm²,

Silambanan³

et al. 2013

JCDR

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Background: In India, there is a rising burden of chronic diseases like hypertension and diabetes. It has been estimated that 25-40% of these patients are likely to develop chronic kidney disease (CKD), with a significant percentage requiring renal replacement therapy. Haemodialysis is the most common method which is used to treat advanced and permanent kidney failure. Derangements in the metabolism of several toxic and trace elements such as antimony, arsenic cadmium, molybdenum, nickel, and selenium have been reported for several decades in patients with chronically reduced renal functions. Overall, the available literature suggests that the blood levels of some elements such as cadmium, chromium, fluorine, iodine, lead, or vanadium are high in end-stage renal disease (ESRD). Aim and Objectives:Our aim was to study the levels of blood arsenic and cadmium in ESRD patients who were on maintenance haemodialysis (MHD), and to study whether there was any relationship between their concentrations and the duration of the MHD. Methods:The blood lead levels were determined in 50 healthy subjects with normal renal functions and in 50 patients with ESRD, who were on MHD. None of them had any history of smoking or any industrial exposure. Results:The results of the study revealed that the blood arsenic and cadmium concentrations were higher in the ESRD patients who were on MHD than in the healthy adults. The blood arsenic and cadmium concentrations were found to increase with the duration of the MHD. Conclusion:The mild increase in the blood arsenic and cadmium concentrations, with an increase in the duration of the MHD in the study population, may be viewed in the wider context, that a prolonged exposure to arsenic and cadmium, even at low levels, may result in renal damage and/or progression of an already existing CKD.

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Section: Resultsmentioning

confidence: 99%

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Palaneeswari

Pm²,

Silambanan³

et al. 2013

JCDR

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“…Although recent improvement of the dialysis technique has made it possible to prevent some serious complications as a result of these changes of trace elements, problems still remain [10].…”

Section: Discussionmentioning

confidence: 99%

“…Some researchers reported that the observed low concentrations of plasma zinc in HD patients may possibly be because of a restricted food intake combined with an impaired absorption of zinc by the intestine [3,10].…”

Section: Discussionmentioning

confidence: 99%

Trace Element Status of Chronic Renal Patients Undergoing Hemodialysis

Kızıltaş

Ekin

Erkoç

2008

Biol Trace Elem Res

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The purpose of this study was to examine the status of trace elements (Cu, Zn, and Fe) and minerals (Mg, K, Na, and Cl) and the level of biochemical parameters (urea, creatinine, total protein, albumin, and glucose) in hemodialysis (HD) patients. This study included 30 HD patients (25 men and 5 women) aged 52.12 +/- 3.13 years and 30 healthy subjects (23 men and 7 women) aged 51.64 +/- 2.22 years. This study investigated the status of trace elements and minerals in HD patients. It was found that the total HD patients (before and after dialysis) had statistically lower Zn and albumin in the after-dialysis group K and Cl levels and higher Mg, creatinine, and urea in the before-dialysis group K and in the after-dialysis group glucose levels than those of the controls. It was determined that the results might be helpful in monitoring patients with renal failure in terms of insufficiency or excess of trace elements and minerals. There was positive correlation for Mg-K (r = 0.64; p = 0.001), creatinine-urea (r = 0.59; p = 0.001), K-urea (r = 0.56; p = 0.001), K-creatinine (r = 0.52; p = 0.003), Mg-creatinine (r = 0.47; p = 0.008), Zn-albumin (r = 0.40; p = 0.028), and Zn-creatinine (r = 0.40; p = 0.031) in the before-dialysis session. There was also positive correlation for creatinine-urea (r = 0.56; p = 0.001), K-urea (r = 0.39; p = 0.035), and Mg-creatinine (r = 0.38; p = 0.041) in the after-analysis session. As a result of the analysis of regression between serum levels of albumin and zinc in total HD patients, the use of the level of albumin might be a suitable choice in determining zinc deficiency resulting from the decrease in the level of zinc in parallel to that of albumin. The results also suggest that the relationship between creatinine and K, Mg, and Zn could be ascribed to the loss of renal function.

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“…In End-Stage Renal Disease (ESRD) patients, different factors affect whole blood and serum level of trace elements, such as increased oral intake, failure of renal excretion, grade of renal failure and metabolic changesrelated with renal failure (Miura et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Copper and Zinc Serum Level in Patients Receiving Hemodialysis

Raoofi¹,

Hakimelahi²,

Sanie³

et al. 2015

OnLine Journal of Biological Sciences

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Decreased kidney function can accumulate trace elements. Increased trace elements can have toxic features. On the other hand, studies are showing that concentration of some trace elements could be decreased in chronic kidney disease patients as well. Because these patients are at risk for alterations of trace elements, we measured serum level of zinc and copper trace elements in hemodialysis patients and compare it with the control group. We analyzed the trace elements' copper and zinc concentration in the whole blood of 52 ESRD patients who were treated with hemodialysis as case group and also of 52 age and sex matched healthy people as control group. Whole blood trace element concentration was determined by atomic absorption spectrometry. The serum concentrations of zinc and copper were significantly lower in case group compared to control group. The serum concentration of zinc and copper trace elements in end-stage renal failure patients is disturbed. Due to the discrepancy in findings of different studies, further studies in large scale are recommended to determine the serum concentration of trace elements in these patients.

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Trace elements in renal disease and hemodialysis

Cited by 24 publications

References 19 publications

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Trace Element Status of Chronic Renal Patients Undergoing Hemodialysis

Copper and Zinc Serum Level in Patients Receiving Hemodialysis

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