Trace elements in human cancerous and healthy tissues: A comparative study by EDXRF, TXRF, synchrotron radiation and PIXE

Zinc Inhibits Hedgehog Autoprocessing

“…Decrease in zinc is observed early in the course of prostate cancer development, and the trend continues toward castration-resistant disease (40). Several studies showed the depression of zinc concentration in the cancerous human lung tissues, especially in the small cell lung cancer, the most malignant form in lung cancer (17,19,41). For ovarian cancer, serum zinc decreased in patients subsequently diagnosed with ovarian cancer, whereas in tumor tissue, the concentration of zinc also decreased (20,21).…”

Determination of cadmium, cobalt, copper, iron, manganese, and zinc in thyroid glands of patients with diagnosed nodular goitre using ion chromatography

“…Engström et al described the potential of inductively coupled plasma-sector field mass spectrometry (ICP-SFMS) in the determination of 68 elements in various animal tissues [16]. Inductively coupled plasma atomic emission spectrometry (ICP-AES) [17], neutron activation analysis (NAA) [18], X-ray fluorescence spectrometry (XRF) [19], total-reflection X-ray fluorescence (TRXRF) [20], particleinduced X-ray emission (PIXE) [21] are the other most commonly used techniques in trace analysis of human tissues and body fluids.…”

Abstracts

“…Bromine is always increased in diseased breast samples and Zn shows a tendency to decrease or to remain constant (Geraki et al 2002). For Fe and Cu, a tendency for an increase in tumor samples was observed, while the remaining observed elements did not show a special pattern (Carvalho et al 2007). The decrease of Zn in cancerous tissues is in agreement with low Zn levels found in other pathologies, e.g., atherosclerosis, malignant tumors, and cirrhotic liver (Carvalho et al 2001).…”