Trace elements in diabetes mellitus. Peculiarities and clinical validity of determinations in blood cells

Kruse-Jarres, J. D.; Rükgauer, M.

doi:10.1016/s0946-672x(00)80019-x

Cited by 73 publications

(75 citation statements)

References 16 publications

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“…Mg deficiency correlated significantly with the intima-media thickness. The element Se was decreased in the plasma of patients with diabetes, and -consistent with the findings of Kruse-Jarres et al [16] -the current study did not demonstrate any significant difference in the levels of Se between children with T1DM and the controls. However, a decreased level of Se in patients with diabetes, regardless of their gender and age, was reported in a study by Nawarro-alarcon et al [26], and a negative correlation with Hba 1c in a study by Ruiz et al [27] The results of the current study did not demonstrate that Se had any effect on metabolic control or the duration of diabetes.…”

Section: Discussionsupporting

confidence: 92%

“…This study evaluated the levels of elements that participate in various mechanisms of antioxidant defense. Kruse-Jarres et al [16] compared the levels of Zn, cu, cr, and Se in complete blood, plasma, and in blood morphotic elements (erythrocytes, platelets, neutrophils) in children with T1DM and in patients with type 2 diabetes mellitus (T2DM). They measured higher cu levels in all the investigated fractions of patients with T1DM.…”

Section: Discussionmentioning

confidence: 99%

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Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Salmonowicz¹,

Krzystek−Korpacka²,

Noczyńska³

2014

Adv Clin Exp Med

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Background. Magnesium (Mg), selinium (Se), zinc (Zn), manganese (Mn), and copper (cu) are involved in the mechanisms of antioxidant defense. Mn and cu, which participate in the generation of reactive oxygen species (ROS), also have pro-oxidative properties. Objectives. To evaluate the levels of Mg, Se, Zn, Mn, and cu, as well as the effectiveness of antioxidant defense mechanisms in children with Type 1Diabetes Mellitus (T1DM) and in their siblings. The preliminary findings were originally reported in 2009 at the 35 th annual conference of the International Society for Pediatric and adolescent Diabetes (ISPaD) in Ljubljana, Slovenia. Material and Methods. The study involved 87 children with T1DM, 2-19 years old, treated for T1DM for an average of 3.5 years. The sibling and control groups comprised 27 and 41 children, aged 4.5-16.5 years and 10.5-18 years respectively. The parameters named above were assessed in relation to metabolic compensation levels (Hb a1c ) and disease duration. Results. compared with the control group, T1DM children had lower plasma levels of Mg and Zn and higher levels of cu; the siblings had lower levels of Zn; T1DM children had lower copper/zinc superoxide dismutase (cuZnSOD) activity; and both T1DM children and their siblings had higher catalase (caT) activity and lower total antioxidant status (TaS) levels. Conclusions. There may be a correlation between impaired antioxidant status and Mg and Zn deficiency and increased cu levels in T1DM children. Oxidative stress in T1DM is accompanied by alterations in enzymatic activity and non-enzymatic mechanisms of antioxidant defense. The decreased TaS levels noted in T1DM patients may impair the effectiveness of non-enzymatic antioxidant systems. The increased caT activity and unimpaired selenium-dependent glutathione peroxidase (Se-GSHPx) activity point indirectly to enhanced ROS generation in T1DM children. The impaired antioxidant defense found in the siblings of T1DM patients may indicate that genetic factors play a role (Adv Clin Exp Med 2014, 23, 2, 259-268).

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Salmonowicz¹,

Krzystek−Korpacka²,

Noczyńska³

2014

Adv Clin Exp Med

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“…Insulin action was reported to be potentiated by some trace elements like chromium, magnesium, vanadium, zinc, manganese, molybdenum and selenium [6]. Proposed mechanisms of enhancement of insulin action by trace elements include activation of insulin receptor sites [7], serving as cofactors or components for enzyme systems which are involved in glucose metabolism [8], increasing insulin sensitivity and acting as antioxidants for preventing tissue peroxidation [9].…”

Section: Introductionmentioning

confidence: 99%

Trace Elements in Diabetes Mellitus

Praveeena¹,

Pasula²,

K³

2013

JCDR

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Introduction: Diabetes Mellitus is the commonest major metabolic disease and most prevalent diseases worldwide. Its related morbidity is due to its micro and macro angiopathic complications. Aim:The aim of this study was to measure and compare the serum levels of zinc and magnesium in normal individuals and in diabetic patients.Method: Analysis of minerals was done in plasma by using a Varian Spectra AA 220 model atomic absorption spectrophotometer. Result:Our observations showed a definite lowering of serum magnesium (p<0.001) and serum zinc levels (p<0.001) were significant in diabetic group. Conclusion:The cause of diabetic hypomagnesaemia is multifactorial. An altered metabolism, a poor glycaemic control and osmotic diuresis may be contributory factors. Decreased serum zinc levels in diabetes may be caused by an increase in urinary loss. These decreased levels of trace elements cause disturbances in glucose transport across cell membrane lead to insufficient formation and secretion of insulin by pancreas which compromise in the antioxidant defense mechanisms.

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“…In a study (Kruse-Jarres & Rukgauer, 2000), serum levels of selenium in both diabetics and non-diabetics control group was measured in three components of plasma, erythrocytes and complete blood that in all three components, selenium concentration was lower in the diabetic group and this decrease is more clearly shown in erythrocytes . Additionally, in another study, serum level of selenium in patients with diabetes mellitus was determined compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

Serum Selenium Status in Patients with Type 2 Diabetes and Control Group

Heidari

Sepehri

Doostdar

2016

GJHS

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In addition to known risk factors, the role of different micronutrients such as selenium in diabetes incidence has been proposed. Some previous studies have shown an association of selenium deficiency and type 2 diabetes mellitus, while other studies have not confirmed such a relationship. The aim of this study was to evaluate serum level of selenium in patients with Type 2 diabetes compared with the control group. This cross-sectional study was carried out on patients with type 2 diabetes in Zahedan, southeastern Iran. One hundred newly diagnosed type 2 diabetic patients were evaluated for serum selenium level. One hundred subjects from the general population who had normal fasting blood sugar levels were selected as the control group. The control group subjects were matched in pairs with each of patients on the basis of sex, age (± one year), and body mass index (±1). Serum level of selenium was determined by spectrometry method. Results were compared using t-test. The mean serum level of selenium in patients was 94.47±18.07 µg/L whereas in control group was 142.79±23.67 µg/L. The mean serum level of selenium was significantly different between the two groups (P<0.001). Serum levels of selenium in diabetic patients with significant difference statistically were lower than the control group. In order to evaluate serum level of selenium in patients with diabetes, studies with larger sample size are required. Likewise, prospective studies along with selenium supplementation and investigating its effect on incidence of diabetes are accordingly needed.

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Trace elements in diabetes mellitus. Peculiarities and clinical validity of determinations in blood cells

Cited by 73 publications

References 16 publications

Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Trace Elements in Diabetes Mellitus

Serum Selenium Status in Patients with Type 2 Diabetes and Control Group

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