Trace Elements in Chronic  Haemodialysis Patients and Healthy  Individuals-A Comparative Study

Lokesh, S.; Green, Siva Ranganathan; Radhakrishnan, Hema; Kadavanu, Tony; Ramachandrappa, Arunkumar; Tiwari, Shashank Rakesh; Rajkumar, Amirtha Lakshmi; Ezhumalai, G

doi:10.7860/jcdr/2016/22031.8618

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…The GM of blood Cs levels is 2.39 μg/L in this study, which is similar in China (2.01 μg/L) [ 17 ] and a little less in India (1.0 μg/L) [ 18 ]. In the present study, GM of blood Cs levels was 2.65 μg/L for men and 2.45 μg/L for women ( p < 0.001).…”

Section: Discussionsupporting

confidence: 64%

Determination of Trace Metal Levels in the General Population of Korea

Kim

Lim

Lee

et al. 2017

IJERPH

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The purpose of this study was to determine the levels of trace metals in the blood of the general Korean population. A total of 258 healthy individuals, according to their regular medical check-ups, (119 males and 139 females, age ranging from 12 to 78 years old) were enrolled from December 2014 to December 2016. Levels of 10 trace elements were determined using inductively coupled plasma mass spectrometry (ICP-MS). The geometric mean (GM) levels for lead, arsenic, cesium, mercury, aluminum, cadmium, copper, manganese, selenium, and zinc were 15.97 μg/L, 7.19 μg/L, 2.39 μg/L, 3.41 μg/L, 10.57 μg/L, 0.78 μg/L, 979.8 μg/L, 11.06 μg/L, 111.37 μg/L, and 872.7 μg/L, respectively. There were significant gender-related differences in the levels of several metals; male individuals had higher Pb, As, Cs, Hg, and Se than females, while females had higher Cd, Cu, and Mn than males. We noticed remarkably high blood levels of Hg, As and Al in the Korean population. The element concentrations reported represent a new contribution to the knowledge of the blood chemistry for the Korea population. The data can be used to assess the clinical health of this population.

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Section: Discussionsupporting

confidence: 64%

Determination of Trace Metal Levels in the General Population of Korea

Kim

Lim

Lee

et al. 2017

IJERPH

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“…However, the high content of heavy metals, mercury in particular, in large wild fish is also known, and another high risk category, that of pregnant women, are counseled to avoid eating them, as mercury can impede foetal growth. While our knowledge of such hidden dangers in the overall population is constantly accumulating, the little that is known about dialysis patients identifies them as a population at high risk for the chronic poisoning agents of our polluted world [ 112 , 113 , 114 , 115 , 116 ].…”

Section: Diet and Dialysis: Four Questions And Four Paradoxesmentioning

confidence: 99%

The Diet and Haemodialysis Dyad: Three Eras, Four Open Questions and Four Paradoxes. A Narrative Review, Towards a Personalized, Patient-Centered Approach

et al. 2017

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The history of dialysis and diet can be viewed as a series of battles waged against potential threats to patients’ lives. In the early years of dialysis, potassium was identified as “the killer”, and the lists patients were given of forbidden foods included most plant-derived nourishment. As soon as dialysis became more efficient and survival increased, hyperphosphatemia, was identified as the enemy, generating an even longer list of banned aliments. Conversely, the “third era” finds us combating protein-energy wasting. This review discusses four questions and four paradoxes, regarding the diet-dialysis dyad: are the “magic numbers” of nutritional requirements (calories: 30–35 kcal/kg; proteins > 1.2 g/kg) still valid? Are the guidelines based on the metabolic needs of patients on “conventional” thrice-weekly bicarbonate dialysis applicable to different dialysis schedules, including daily dialysis or haemodiafiltration? The quantity of phosphate and potassium contained in processed and preserved foods may be significantly different from those in untreated foods: what are we eating? Is malnutrition one condition or a combination of conditions? The paradoxes: obesity is associated with higher survival in dialysis, losing weight is associated with mortality, but high BMI is a contraindication for kidney transplantation; it is difficult to limit phosphate intake when a patient is on a high-protein diet, such as the ones usually prescribed on dialysis; low serum albumin is associated with low dialysis efficiency and reduced survival, but on haemodiafiltration, high efficiency is coupled with albumin losses; banning plant derived food may limit consumption of “vascular healthy” food in a vulnerable population. Tailored approaches and agreed practices are needed so that we can identify attainable goals and pursue them in our fragile haemodialysis populations.

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Trace Elements and Chronic Kidney Disease: A Cross-Sectional Study from Jamaica

et al. 2021

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Background: Several environmental studies have reported that low-level exposure to nephrotoxic elements increases the risk of chronic kidney disease (CKD). In developing countries, finite resources can limit epidemiological studies and environmental risk assessment; however, the unique soil profile in Jamaica has raised some concerns for the potential exposure to populations who are of high risk. Method: This study investigated the potential for using trace element profiling in CKD, by analysing blood concentration levels of vanadium, chromium, iron, cobalt, copper, zinc, selenium, strontium (Sr), arsenic, barium, cadmium, mercury, and lead. Trace element analysis was conducted using inductively coupled plasma mass spectrometry. Results: One hundred and fifty-eight individuals were included and were predominantly of African descent (98%) and their ages ranged from 21 to 90 years old. Three main correlation clusters were evident: firstly, vanadium, chromium, copper, silicon, and selenium, with mercury and barium more distantly related; secondly, lead, arsenic, nickel, and Sr; and thirdly, iron and zinc. Cadmium was an outlier. Blood Sr was strongly associated with estimated glomerular filtration rate (r = -0.83; p<0.001) and strong linear progression models (r2=0.96; p<0.001). Algorithmic models placed Sr as the highest-ranking trace element biomarker (area under the curve: 95.6%; p<0.001). Discussion: The decline in kidney function may result in the retention of non-essential trace elements. Strong corresponding trends between kidney function and blood Sr concentration indicate biomarker potential for a trace element with a unique profile in patients with CKD. Other significant relationships may also be unveiled as CKD biomarkers as trace element profiling is explored in the region.

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Trace Elements in Chronic Haemodialysis Patients and Healthy Individuals-A Comparative Study

Cited by 5 publications

References 12 publications

Determination of Trace Metal Levels in the General Population of Korea

Determination of Trace Metal Levels in the General Population of Korea

The Diet and Haemodialysis Dyad: Three Eras, Four Open Questions and Four Paradoxes. A Narrative Review, Towards a Personalized, Patient-Centered Approach

Trace Elements and Chronic Kidney Disease: A Cross-Sectional Study from Jamaica

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