Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease

Abstract

Aim: In the present study, we aimed to assess serum concentrations of zinc (Zn), copper (Cu), iron (Fe), cadmium (Cd), lead (Pb), manganese (Mn), vitamins A (retinol), D (cholecalciferol) and E (α-tocopherol) in patients with coronary artery disease (CAD) and to compare with healthy controls.Methods: A total of 30 CAD patients and 20 healthy subjects were included in this study. Atomic absorption spectrophotometry (UNICAM-929) was used to measure heavy metal and trace element concentrations. Serum α-tocopherol, retinol and cholecalciferol were measured simultaneously by high performance liquid chromatography (HPLC).Results: Demographic and baseline clinical characteristics were not statistically different between the groups. Serum concentrations of retinol (0.3521±0.1319 vs. 0.4313±0.0465 mmol/I, p=0.013), tocopherol (3.8630±1.3117 vs. 6.9124±1.0577 mmol/I, p<0.001), cholecalciferol (0.0209±0.0089 vs. 0.0304±0.0059 mmol/I, p<0.001) and Fe (0.5664±0.2360 vs. 1.0689±0,4452 µg/dI, p<0.001) were significantly lower in CAD patients. In addition, while not statistically significant serum Cu (1.0164±0.2672 vs. 1.1934±0.4164 µg/dI, p=0.073) concentrations were tended to be lower in patients with CAD, whereas serum lead (0.1449±0.0886 vs. 0.1019±0.0644 µg/dI, p=0.069) concentrations tended to be higher.Conclusions: Serum level of trace elements and vitamins may be changed in patients with CAD. In this relatively small study we found that serum levels of retinol, tocopherol, cholecalciferol, iron and copper may be lower whereas serum lead concentrations may be increased in patients with CAD.

Investigation of some trace element levels (Zn, Fe, Mn, Mg, Cu, Cd, Co, Pb) in patients with burst fractures

“…[17] As shown in Table 2, serum levels of Zn were lower in the patient group than in the healthy group. Although these findings were consistent with those reported by Cobanoglu et al (2010), [11] Mazdak et al (2010), [18] and Cebi et al (2010), [10] they contradicted the findings reported for patients with malignant glioma by Arslan et al [19] Although Zn has the ability to stimulate collagen synthesis in osteoblasts and activate alkaline phosphatase, these processes have a crucial role in the mineralization and calcification of bones. [20] Zn deficiency is commonly associated with numerous disorders such as retarded bone growth.…”

“…[7][8][9] Neurological injury has been shown to occur in 30%-90% of patients with burst fracture due to damage in the proximal portion of the spinal cord, conus medullaris, or the filaments of the cauda equina. [10,11] The treatment of burst fractures remains controversial. Some authors propose non-surgical methods, such as resting for a while, stability, or medical treatments, unless neurological…”

Comparative Study of Elemental Concentrations in the Scalp Hair and Nails of Myocardial Infarction Patients Versus Controls from Pakistan

“…In past few studies, the Mn content was reported higher in plasma of atherosclerosis patients than in controls but showed less accumulation in heart and aorta of the patients. Cebi et al [5] revealed that the rise of Mn level in plasma of patients is so rapid and specific that it may be used as a diagnostic indicator for recent MI. Strontium was significantly associated with increased events of cardiovascular diseases.…”

“…The major underlying pathology in atherosclerosis is the slow development and subsequent rupture of thrombogenic lipidladen plaques in the blood vessels leading to tissue hypoxia and necrosis that shows as heart attack [3,4]. Studies on the roles of trace elements in health and disease over the past 50 years have led to a good understanding of their mode of actions and their essentiality to life [5]. For instance, elemental deficiency and toxicity effects should be accompanied by changes in pathology and status of immunoactivity of the body; because some elements are essential component of enzymes, hormones, and other biological active substances [6].…”

Levels of serum trace elements in ischemic stroke patients

“…Cebi et al, (2011) analyzed the serum Cd levels in patients with coronary artery diseases but determined no significant differences between them and a healthy control group. However, no study has been found in the literature that evaluates Cd levels in IS patients.…”