Trace Elements and Skin Pigmentation

Molokhia, Mohamed M.; Portnoy, Benjamin

doi:10.1111/j.1365-2133.1973.tb02958.x

Cited by 7 publications

(1 citation statement)

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“…Heavy metals can also elicit hyperpigmentation, which can arise after the extensive use of drugs containing arsenic, bismuth, gold, or silver (98). The metals are believed to act by binding, and thereby inactivating, sulfydryl compounds in the skin that normally inhibit TYR activity.…”

Section: The Action Of Drugs Chemicals Etc On Human Skin Pigmentamentioning

confidence: 99%

Human skin pigmentation: melanocytes modulate skin color in response to stress

2007

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All organisms, from simple invertebrates to complex human beings, exist in different colors and patterns, which arise from the unique distribution of pigments throughout the body. Pigmentation is highly heritable, being regulated by genetic, environmental, and endocrine factors that modulate the amount, type, and distribution of melanins in the skin, hair, and eyes. In addition to its roles in camouflage, heat regulation, and cosmetic variation, melanin protects against UV radiation and thus is an important defense system in human skin against harmful factors. Being the largest organ of the body that is always under the influence of internal and external factors, the skin often reacts to those agents by modifying the constitutive pigmentation pattern. The focus of this review is to provide an updated overview of important physiological and biological factors that increase pigmentation and the mechanisms by which they do so. We consider endocrine factors that induce temporary (e.g., during pregnancy) or permanent (e.g., during aging) changes in skin color, environmental factors (e.g., UV), certain drugs, and chemical compounds, etc. Understanding the mechanisms by which different factors and compounds induce melanogenesis is of great interest pharmaceutically (as therapy for pigmentary diseases) and cosmeceutically (e.g., to design tanning products with potential to reduce skin cancer risk).

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Section: The Action Of Drugs Chemicals Etc On Human Skin Pigmentamentioning

confidence: 99%