Trace elements and diabetes: Assessment of levels in tears and serum

Cancarini, Anna; Fostinelli, Jacopo; Napoli, Luca; Gilberti, Maria Enrica; Apostoli, Pietro; Semeraro, Francesco

doi:10.1016/j.exer.2016.10.020

Cited by 37 publications

(23 citation statements)

References 32 publications

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“…However, urinary Mn levels of coke oven workers were associated with hyperglycemia risk but not with diabetes risk, which might be due to the small sample size of diabetes and the relatively young population; researchers also found that the concentrations of urinary Mn in the occupational population were higher than those in the general population [ 62 , 63 ]. Moreover, results were inconsistent in some studies concerning the Mn concentration in the samples of scalp hair, tears, and lymphocytes among individuals with T2DM [ 56 , 59 , 64 – 66 ].…”

Section: Mn and Type 2 Diabetes Mellitus/insulin Resistancementioning

confidence: 97%

The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions

Yang

2018

Oxidative Medicine and Cellular Longevity

354

225

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Manganese (Mn) is an essential element that is involved in the synthesis and activation of many enzymes and in the regulation of the metabolism of glucose and lipids in humans. In addition, Mn is one of the required components for Mn superoxide dismutase (MnSOD) that is mainly responsible for scavenging reactive oxygen species (ROS) in mitochondrial oxidative stress. Both Mn deficiency and intoxication are associated with adverse metabolic and neuropsychiatric effects. Over the past few decades, the prevalence of metabolic diseases, including type 2 diabetes mellitus (T2MD), obesity, insulin resistance, atherosclerosis, hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and hepatic steatosis, has increased dramatically. Previous studies have found that ROS generation, oxidative stress, and inflammation are critical for the pathogenesis of metabolic diseases. In addition, deficiency in dietary Mn as well as excessive Mn exposure could increase ROS generation and result in further oxidative stress. However, the relationship between Mn and metabolic diseases is not clear. In this review, we provide insights into the role Mn plays in the prevention and development of metabolic diseases.

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Section: Mn and Type 2 Diabetes Mellitus/insulin Resistancementioning

confidence: 97%

The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions

Yang

2018

Oxidative Medicine and Cellular Longevity

354

225

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“…50,51 It has been reported that selenium concentration was higher in diabetic patients than in healthy people. 52,53 Once developing DM, the body needs more antioxidant species to fight against oxidative and inflammatory responses. Therefore, selenium as a potent antioxidant and a physiological modulator is inspired for use in DM care.…”

Section: Se-based Nanomedicines For Oncotherapymentioning

confidence: 99%

Selenium as a pleiotropic agent for medical discovery and drug delivery

Guan¹,

Yan²,

Li³

et al. 2018

IJN

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Selenium as a biologically active element lends much support to health maintenance and disease prevention. It is now presenting pleiotropic effects on therapy and drug delivery. In this study, a profiling on the physiological functions, therapeutic significances, clinical/preclinical performances, and biomedical and drug delivery applications of selenium in different modalities was carried out. Major interests focused on selenium-based nanomedicines in confronting various diseases pertaining to selenium or not, especially in antitumor and antidiabetes. Furthermore, the article exclusively discusses selenium nanoparticles featured by ameliorative functions with emphasis on their applications in medical practice and drug delivery. The state-of-the-art in medical discovery as well as research and development on selenium and nano-selenium is discussed in this review.

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“…The advantage of the method was its non-invasive character. They found that there were significantly higher levels of zinc, chromium and cobalt, manganese, barium, and lead in the tears of diabetic patients than in a healthy control group (7).…”

Section: Introductionmentioning

confidence: 98%

Potential of Selected Trace Elements in Patients with Diabetes Mellitus

Ferencikova

Osina

2018

Acta Medica Martiniana

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Based on the high prevalence, diabetes mellitus (DM) is considered as a worldwide problem. More than 8.3 % of the world population is suffering from this disease. One of the causing factors of this disease can be the absence or imbalance of trace, essential elements. It can cause collapses of antioxidant defence and glucose intolerance. It plays a role in the pathogenesis and progression to diabetes mellitus. This review focuses on chromium, copper, selenium, vanadium, and zinc. Many studies deal with these elements but there is variability in opinions. Insulin-mimetic activity and ability to control the concentrations of blood glucose were confirmed. However, these effects were of more importance in patients with prediabetes. In patients with prediabetes, due to the supplementation of selected trace elements, it is possible to normalize the blood glucose level and prevent the development of diabetes mellitus. The importance of supplementation was confirmed for chromium and zinc. The supplementation of vanadium has a positive effect on the normalization of glycaemia but it is necessary to control the level as it can have toxic effects during long-term treatment. Conversely, higher copper concentrations in the body adversely affect patients and chelation therapy is needed. Selenium must be kept in the standard concentration and regular control of the concentration in the body is necessary. For this reason it is necessary to continue with analysis and the creation of new methodologies that could unify the view on the issue.

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Trace elements and diabetes: Assessment of levels in tears and serum

Cited by 37 publications

References 32 publications

The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions

The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions

Selenium as a pleiotropic agent for medical discovery and drug delivery

Potential of Selected Trace Elements in Patients with Diabetes Mellitus

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