Trace elements and antioxidant enzymes associated with oxidative stress in the pre-eclamptic/eclamptic mothers during fetal circulation

Negi, Reena; Pande, Deepti; Karki, Kanchan; Kumar, Ashok; Khanna, Ranjana S.; Khanna, Hari D.

doi:10.1016/j.clnu.2012.04.005

Cited by 64 publications

(47 citation statements)

References 25 publications

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“…However, low levels of Mn and Zn had an eff ect on the inhibition of LOO˙ as the correlations were mostly negative. These results contradict previous studies where these minerals were found to contribute to cell defense against ROS (30,31). For example, Zn showed protective eff ects against oxidative damage and lipid peroxidation in cellular environment (35,36).…”

Section: Correlation Between Antioxidant Activities and Tac Tfc Tpccontrasting

confidence: 56%

“…However, excess of Fe was reported to catalyze the generation of ROS in a cellular study (35). These confl icting results could be explained by the protective mechanism of these minerals that was achieved by forming a complex structure with some specifi c cellular molecules, such as superoxide dismutase, catalase and glutathione peroxidase (30)(31)(32)36). Thus, the chemical reactions in the antioxidant assays used in this experiment may limit the activities of trace elements and prevent their interaction with ROS.…”

Section: Correlation Between Antioxidant Activities and Tac Tfc Tpcmentioning

confidence: 91%

“…Some trace elements such as Zn, Se, Cu and Mn were reported to be included in human cell defense mechanisms against reactive oxygen species (ROS) (30,31). These minerals act as cofactors of several antioxidant enzymes.…”

Section: Mineral Profi Le Of Black Glutinous Rice Branmentioning

confidence: 99%

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Correlation of Phytochemical, Metal Contents and Antioxidant Activities of Black Glutinous Rice Bran and Potential Chemoprevention

Ngamdee

Wichai

Jiamyangyuen

2016

Food Technol. Biotechnol.

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SummaryIn this work total anthocyanin content (TAC), total fl avonoid content (TFC), total phenolic content (TPC) and minerals found in fi ve black glutinous rice cultivars (MS, SK, PY, PC and KK) from Thailand were analyzed. The antioxidant activity of anthocyanin-rich black glutinous rice bran extracts against nitric oxide radical (NO˙), superoxide radical (O 2˙¯) and lipid peroxyl radical (LOO˙) was also determined. Potential chemopreventive property of rice bran extract was screened based on cellular bioassays for phase II detoxification enzyme induction. Quinone reductase (QR) induction in murine hepatoma cells was used as a marker for this eff ect. Rice bran extract of cultivar KK had the highest TAC, of SK the highest TFC and of PC the highest TPC. The best antioxidants against NO˙, O 2˙¯ and LOO˙ were cultivars KK, MS, and SK, respectively. Overall, TAC, TFC and TPC had a combinatorial eff ect on the antioxidant activities of all extracts; none of them dominated. Minerals may not play a role in the antioxidant activity of the extracts because most correlations between them and the antioxidant activity were unpredictable. However, rice bran contained high mass fractions of some essential minerals on dry mass basis, including Zn (103-133 μg/g), Se (11-18 μg/g) and Cu (3.8-7.1 μg/g). Chemopreventive study indicated that PC cultivar was the most potent chemopreventor with the lowest concentration of an inducer needed to double the QR activity (CD value) of 0.7 μg/mL. These fi ndings showed that black glutinous rice bran is rich in phytochemicals and some essential minerals, and has a potential chemopreventive property.

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Section: Correlation Between Antioxidant Activities and Tac Tfc Tpccontrasting

confidence: 56%

Section: Correlation Between Antioxidant Activities and Tac Tfc Tpcmentioning

confidence: 91%

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Correlation of Phytochemical, Metal Contents and Antioxidant Activities of Black Glutinous Rice Bran and Potential Chemoprevention

Ngamdee

Wichai

Jiamyangyuen

2016

Food Technol. Biotechnol.

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“…Although a limited number of studies have been carried out on fetal oxidative status and umbilical cord blood, the results have consistently shown an upregulation of oxidative stress markers and altered antioxidant status in fetal circulation [ 58 ]. The fetus is affected by oxidative stress in PE, and this raises a concern about fetal and neonatal outcomes [ 59 , 60 ].…”

Section: Oxidative Damage Markersmentioning

confidence: 99%

Oxidative Stress in Low Birth Weight Newborns

Negi

Pande

Karki

et al. 2014

Free Radicals in Human Health and Disease

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Free radical damage has been recognized to be a common pathogenic mechanism of many neonatal diseases. An excessive and/or sustained increase in free radical production associated with diminished effi cacy of the antioxidant defense systems results in oxidative stress, which occurs in many pathologic processes and contributes signifi cantly to disease and can be the key link between size at birth and increased morbidity later in life. Low birth weight is closely associated with fetal and neonatal mortality and morbidity, inhibited growth and cognitive development, and chronic diseases later in life. Low birth weight is considered the primary factor associated with a poor perinatal outcome of maternal preeclampsia/ eclampsia and premature birth. High oxidative stress and low level of enzymatic antioxidants and antioxidant nutrients such as vitamins A, E, and C, zinc, copper, and selenium and antioxidant status might be increasing the risk of pathogenesis of major complications in low birth weight newborns.

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“…Alternatively, many studies have found that maternal, fetal or placental Se concentrations positively correlate with fetal growth and successful pregnancies (Bogden et al, 2006; Klapec et al, 2008; Negi et al, 2012; Sun et al, 2014; Rayman et al, 2011, 2015, 2003). The adverse Cd-associated pregnancy and birth outcomes may be mitigated by concurrently higher levels of Se.…”

Section: Introductionmentioning

confidence: 99%

Maternal exposure to selenium and cadmium, fetal growth, and placental expression of steroidogenic and apoptotic genes

Everson

Kappil

Hao

et al. 2017

Environmental Research

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Background Cadmium (Cd) and selenium (Se) antagonistically influence redox balance and apoptotic signaling, with Cd potentially promoting and Se inhibiting oxidative stress and apoptosis. Alterations to placental redox and apoptotic functions by maternal exposure to Cd and Se during pregnancy may explain some of the Cd and Se associations with fetal development. Objectives Investigate associations between Cd and Se concentrations in maternal toenails with placental expression patterns of tumor necrosis factor (TNF) and steroidogenic genes involved in redox reactions and test associations with fetal growth. Methods In a sub-sample from the Rhode Island Child Health Study (n = 173), we investigated the relationships between: (1) maternal toenail Cd and Se concentrations and fetal growth using logistic regression, (2) Cd and Se interactions with factor scores from placental TNF and steroidogenic expression patterns (RNAseq) using linear models, and (3) TNF and steroidogenic expression factors with fetal growth via analysis of covariance. Results Se was associated with decreased odds of intrauterine growth restriction (IUGR) (OR = 0.27, p-value = 0.045). Cd was associated with increased odds of IUGR (OR = 1.95, p-value = 0.13) and small for gestational age (SGA) births (OR = 1.46, p-value = 0.11), though not statistically significant. Cd and Se concentrations were antagonistically associated with placental TNF and steroidogenic expression patterns, which also differed by birth size. Conclusions Se may act as an antagonist to Cd and as a modifiable protective factor in fetal growth restriction, and these data suggest these effects may be due to associated variations in the regulation of genes involved in placental redox balance and/or apoptotic signaling.

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Trace elements and antioxidant enzymes associated with oxidative stress in the pre-eclamptic/eclamptic mothers during fetal circulation

Cited by 64 publications

References 25 publications

Correlation of Phytochemical, Metal Contents and Antioxidant Activities of Black Glutinous Rice Bran and Potential Chemoprevention

Correlation of Phytochemical, Metal Contents and Antioxidant Activities of Black Glutinous Rice Bran and Potential Chemoprevention

Oxidative Stress in Low Birth Weight Newborns

Maternal exposure to selenium and cadmium, fetal growth, and placental expression of steroidogenic and apoptotic genes

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