Trace Elements Alleviate Pain in Mice and Humans

Tamba, Bogdan Ionel; Alexa-Stratulat, Teodora

doi:10.1016/b978-0-12-805186-3.00017-5

Cited by 2 publications

(2 citation statements)

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“…In addition, stable Sr isotopes do not have any significant health threat (Gulson & Wong, 2006 ). Sr functions as a moderately effective antiresorptive agent in humans (Tamba & Alexa‐Stratulat, 2017 ). In the clinical setting, therapeutic uses of Sr salts such as strontium ranelate (SrR) are involved in preventing osteoporotic fractures (Meunier et al, 2004 ).…”

Section: Introductionmentioning

confidence: 99%

“…In the clinical setting, therapeutic uses of Sr salts such as strontium ranelate (SrR) are involved in preventing osteoporotic fractures (Meunier et al, 2004 ). Sr appeared to stimulate bone formation and inhibit bone resorption in rodents (Tamba & Alexa‐Stratulat, 2017 ). In poultry, the average intake of Sr is about 19 mg/kg of feed (Doberenz et al, 1969 ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of strontium ranelate and cerium oxide addition in the diet on bone quality and expression level of osteocalcin and alkaline phosphatase genes in broiler chicken

Sabir

ABBAS

2023

Veterinary Medicine & Sci

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Background: In the modern broiler industry, leg and gait disorders are considerable problems. Fast-growing broilers are especially susceptible to bone abnormalities, causing major problems for broiler producers. Strontium ranelate (SrR) has been used successfully for the treatment of osteoporosis in humans. In addition, cerium oxide (CeO) is an anti-stress agent applied in the biological system.Methods: This study was conducted to investigate the effect of SrR, CeO, and their combinations on tibia quality in broilers. A total of 384 one-day-old Ross chicks were divided into six treatments, with four replicates per treatment (16 birds per replicate).The control group was fed a standard diet, and other groups were fed SrR at levels 450, 900 mg/kg feed, CeO at levels 300 and 600 mg/kg feed and a combination of 450 SrR + 300 CeO mg/kg feed. Bone mineral density (BMD), bone mineral content (BMC), bone strength (BS), tibia area, tibia weight, bone Length, bone diameter, minerals in tibia bone of male broilers, alkaline phosphatase gene (ALP) and osteocalcin gene (OC) in male broilers were analysed. Results:The results showed that the addition of SrR and CeO had no significant influence (p > 0.01) on BMD, BMC, BS, bone weight, bone length and bone diameter. While there was a significant interaction between sex and treatments, especially in the combination group, BS in females significantly (p < 0.01) increased compared to the control group. Generally, females were found to be more responsive to treatments than males.Significant increases in gene expression were noticed in OC with the addition of low levels of SrR and CeO and mixed group compared to the control. The gene expression of ALP was increased significantly only in a combination group compared to the control group. Conclusion:It is concluded that SrR and CeO can be used as beneficial additives in the feed to improve the tibia quality of broilers.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of strontium ranelate and cerium oxide addition in the diet on bone quality and expression level of osteocalcin and alkaline phosphatase genes in broiler chicken

Sabir

ABBAS

2023

Veterinary Medicine & Sci

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Selenium Donors at the Junction of Inflammatory Diseases

Alhasan

Kharma

Leroy

et al. 2019

CPD

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Selenium is an essential non-metal trace element, and the imbalance in the bioavailability of selenium is associated with many diseases ranking from acute respiratory distress syndrome, myocardial infarction and renal failure (Se overloading) to diseases associated with chronic inflammation like inflammatory bowel diseases, rheumatoid arthritis, and atherosclerosis (Se unload). The only source of selenium is the diet (animal and cereal sources) and its intestinal absorption is limiting for selenocysteine and selenomethionine synthesis and incorporation in selenoproteins. In this review, after establishing the link between selenium and inflammatory diseases, we envisaged the potential of selenium nanoparticles and organic selenocompounds to compensate the deficit of selenium intake from the diet. With high selenium loading, nanoparticles offer a low dosage to restore selenium bioavailability whereas organic selenocompounds can play a role in the modulation of their antioxidant or antiinflammatory activities.

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Trace Elements Alleviate Pain in Mice and Humans

Cited by 2 publications

References 122 publications

Effect of strontium ranelate and cerium oxide addition in the diet on bone quality and expression level of osteocalcin and alkaline phosphatase genes in broiler chicken

Effect of strontium ranelate and cerium oxide addition in the diet on bone quality and expression level of osteocalcin and alkaline phosphatase genes in broiler chicken

Selenium Donors at the Junction of Inflammatory Diseases

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