Trace Element Studies on Tinospora cordifolia (Menispermaceae), Ocimum sanctum (Lamiaceae), Moringa oleifera (Moringaceae), and Phyllanthus niruri (Euphorbiaceae) Using PIXE

Ramadurai, Gowrishankar; Kumar, M. Ravi; Menon, Vinay; Divi, Sai Mangala; Saravanan, Mythili; Magudapathy, P.; Panigrahi, Bibhuranjan; Nair, Krishnan; Venkataramaniah, K.

doi:10.1007/s12011-009-8439-1

Cited by 79 publications

(42 citation statements)

References 19 publications

(17 reference statements)

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“…[28] Administration of OS to streptozocin-induced diabetic rats for 30 days significantly reduced the plasma level of TBARS and improved the status of the antioxidant enzymes catalase, SOD and GPx in vital organs such as the liver and kidney. [29] Similarly, aqueous extract OS L is sued for management of diabetes and related complications [30,31] (while methanolic extract of OS Linn. reverses dyslipidemia and oxidative stress in alloxan induced type I diabetic rat model.…”

Section: Antidiabeticmentioning

confidence: 99%

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Upadhyay

2017

IJGP

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The present review article explains medicinal and therapeutic uses of Tulsi plant in traditional medicine. Tulsi (Ocimum sanctum [OS] Linn.) is an aromatic plant belongs to family Lamiaceae. It is traditionally used for preparation of various Ayurvedic formulations for treatment of bronchitis, influenza, and asthma. Hot concoction of Tulsi leaves is usually provided for immediate relief in cold, sneezing nose, cough, malaria, and dengue. This article explains the biological effectiveness of OS against diabetes mellitus, hypertension, cancers, respiratory diseases, arthritis, various microbes, and parasites. Tulsi extracts and its various bio-organic constituents showed antioxidant activity, anti-atherogenic effect, anti-aging, immunomodulatory, anti-inflammatory, antistress, hepatoprotective, radioprotective, antihelmintic, repellent and larvicidal activity. Tulsi active ingredients showed anti-inflammatory properties and also play a role in modulation of both cellular and humeral immunity. Plant shows healing properties in hepatic injury and gastric ulcer. It relieves from stress, restore and improve body immunity and digestion. Ocimum basilicum L. contains (-)-linalool, eugenol and methyl chavicol, methyl chavicol (93.0%), gamma-caryophyllene as major constituents. Minor oil constituents are (+)-delta-cadinene, 3-carene, alpha-humulene, citral, and (-)-trans-caryophyllene. Tulsi oil contains high alpha-linolenic acid contents mainly eicosanoid precursor polyunsaturated fatty acids which are anti-inflammatory in nature. Tulsi also contains camphor, caryophyllene oxide, cineole, methyleugenol, limonene, myrcene, and thymol, which are known insect repellents. Its essential oil (EO) can be used to abate the growth of mosquitoes and control malaria. It is a good repellant and can be used for deterring flies, mosquitoes and insects. No doubt Tulsi plant is a good source of natural products mainly phyto-constituents and EO which can be used as alternative medicine for the treatment of various ailments and human health problems but proper composition and appropriate formulation is required before being used.

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Section: Antidiabeticmentioning

confidence: 99%

Untitled

Upadhyay

2017

IJGP

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“…This shows that the ethanolic extract possesses the potential to lower reactive free radical levels which may ameliorate oxidative dama- ge and this may be traceable to the rich presence of flavonoids which have antioxidant property (35). M. oleifera is a rich source of anti-oxidants (25)(26)(27) which are largely responsible for its antioxi-dant activity (40)(41).…”

Section: Blood Glucose and Antidiabetic Studiesmentioning

confidence: 99%

“…Highly appreciable levels of four natural antioxidants of dietary origin: vitamins A, C and E and phenolics are found in M. oleifera. Studies have estimated 46 antioxidants in Moringa which are important to cells in combating free radicals (25)(26)(27). This study was therefore aimed at investigating the effect of ethanolic extract of dried flowers of M. oleifera in streptozotocin-induced diabetes in rats.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and Antioxidant Activities of Ethanolic Extract of Dried Flowers of Moringa oleifera in Streptozotocin-induced Diabetic Rats

Arise¹,

Aburo²,

Farohunbi³

et al. 2016

Acta Facultatis Medicae Naissensis

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SU M M A RYThis study was undertaken to determine the antidiabetic and antioxidant effects of oral administration of ethanolic extract of Moringa oleiferaflower on stretozotocin-induced diabetic rats at 100, 200, and 300 mg/kg b.w. Thirty (30) male experimental albino rats were grouped randomly into six groups: groups A, B, and F are the control, diabetic control and reference drug groups, while C-E received 100, 200, and 300mg/kg b.w of the extract, respectively. Blood samples and organs were collected to assay for blood glucose level and antioxidant enzymes.Levels of blood glucose, serum lipids and lipid peroxidation as well as aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine aminotransferase (ALT) activities were significantly reduced (p<0.05) in STZ-induced diabetic rats orally administered ethanolic extract of M. oleifera flower. However, the body weight; catalase and superoxide dismutase activities were significantly increased (p < 0.05) when compared with the controls.M. oleifera flower ethanolic extract administered orally therefore exhibited improved lipid metabolism, glucose-lowering potential and is hence beneficial in preventing diabetic complications as a result of lipid peroxidation and oxidative systems in streptozotocin-induced diabetic rats. It could thus be employed therapeutically in managing diabetes mellitus.

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“…Recientes investigaciones realizadas han demostrado la presencia en sus hojas de elementos traza como Cl, K, Ca, Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn, Br y Sr en concentraciones variables pero siendo lo más relevante los altos niveles de Cr en su extracto (3).…”

Section: Introduccionunclassified

Moringa oleifera acute effect on dexamethasone-induced hyperglycemia in Wistar rats

Santacruz¹,

Barreto

Malvetti

et al. 2016

An. Fac. Cienc. Méd. (Asunción)

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RESUMEN INTRODUCCIÓN:Se han atribuido muchos efectos beneficiosos a la moringa oleífera en varias publicaciones siendo de gran interés su efecto hipoglicemiante por disminución de la absorción intestinal de glucosa, aunque no está definido si su eficacia hipoglicemiante sería igual o mayor a algún hipoglicemiante oral conocido. El objetivo del presente estudio fue determinar el efecto agudo de moringa oleífera en hiperglucemia inducida por dexametasona en ratas Wistar hembras, así como comparar su efecto hipoglicemiante con la metformina. MATERIALES Y MÉTODOS: Estudio experimental, tres grupos de cinco ratas Wistar hembras, con peso de 188 ± 11 gramos. Se realizó la medición de la glucemia basal con glucómetro, después de 12 horas de ayuno, la inicial al principio del experimento, luego fueron tratadas con dexametasona 10 mg/kg/día, subcutánea, durante 10 días y se tomó la glicemia post dexametasona . Los días 11 a 14, recibieron el grupo 1 (suero fisiológico), grupo 2 (moringa oleífera 300 mg/kg/día) y grupo 3 (metformina 14,28 mg/kp/día), por sonda oro gástrica, el día 15 se tomó la glucemia post tratamiento. Se analizó el promedio, desviación estándar y la correlación mediante la prueba la prueba T de Student, se consideró P < a 0,05 como significativa. RESULTADOS: Grupo 1 (control): glucemia inicial (117 ± 21 mg/dl), post-dexametasona (445 ± 260 mg/dl) y post tratamiento (222 ± 5 mg/dL), Grupo 2 (moringa oleífera): glucemia inicial (95±27 mg/dl), post dexametasona (413 ± 184 mg/dl) y post tratamiento (102 ± 18 mg/dl) y del Grupo 3 (metformina): glucemia inicial (110 ± 5 mg/dl), post-dexametasona (470 ± 146 mg/dl) y post tratamiento (88 ± 11 mg/dL). La glucemia pos tratamiento mostró diferencias entre el grupo 1 y 2 (p < 0,0001), entre el grupo 1 y 3 (p < 0,0001) no hallándose diferencias entre los grupos moringa oleífera y metformina (p = 0,1). DISCUSIÓN: la moringa oleífera disminuye en forma aguda la hiperglucemia inducida por dexametasona en ratas hembras Wistar, con la misma eficacia que la metformina Palabras clave: moringa oleífera, hiperglicemia, ratas Wistar, mefformina. ABSTRACTSanta Cruz F et al  Efecto agudo de moringa oleífera sobre la hiperglucemia inducida por ... An. Fac. Cienc. Méd. (Asunción) / Vol. 48 -Nº 1, 2015 42INTRODUCTION: It has been attributed many beneficial effects of moringa oleífera in various publications to be of great interest for its hypoglycemic effect due to decreased intestinal absorption of glucose; although it is not defined if his hypoglycemic efficacy would be equal to or greater than any known oral hypoglycemic agent. The objective of this study was to determine the acute effect of moringa oleífera on hyperclycemia induced by dexamethasone in female Wistar rats and compare its hypoglycemic effect with metformin. MATERIALS AND METHODS: Experimental study, wiht 3 groups of 5 female Wistar rats, weighing 188 ± 11 grams. Measuring the basal blood glucose meter was performed after 12 hours of fasting, the initial glycemia at the beginning of the experiment and were then ...

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Trace Element Studies on Tinospora cordifolia (Menispermaceae), Ocimum sanctum (Lamiaceae), Moringa oleifera (Moringaceae), and Phyllanthus niruri (Euphorbiaceae) Using PIXE

Cited by 79 publications

References 19 publications

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Antidiabetic and Antioxidant Activities of Ethanolic Extract of Dried Flowers of Moringa oleifera in Streptozotocin-induced Diabetic Rats

Moringa oleifera acute effect on dexamethasone-induced hyperglycemia in Wistar rats

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