Trace Element Status and Hypothyroidism: A Systematic Review and Meta-analysis

Ghaedi, Ehsan; Sadeghi, Erfan; Mohammadi, Hamed; Hadi, Amir; Clark, Cain C. T.; Askari, Gholamreza

doi:10.1007/s12011-019-01963-5

Cited by 52 publications

(43 citation statements)

References 52 publications

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“…Of the 8 men with overt hyperthyroidism, only 1 (12.5%) were under treatment. Mean, median and range of participants treated with thiamazole were respectively 7.5 (±1.0), 7.5 (5)(6)(7)(8)(9)(10), and range of 5 to 10 mg. Of the 183 incident cases of hypothyroidism, 49 (26.8%) were identified based on TSH and FT4 levels and 134 (73.2%) were identified by use of medication. Of them, 142 (77.6%) were women and 113 (79.6) of them where under treatment.…”

Section: Resultsmentioning

confidence: 99%

Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Sgarbi

Janovsky

Pittito

et al. 2021

Archives of Endocrinology and Metabolism

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Objective: To evaluate incidence of subclinical and overt hyperthyroidism and hypothyroidism. Subjects and methods: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study of 15,105 civil servants, examined at baseline and over a 4-year follow-up. This analysis included 9,705 participants with normal thyroid function at baseline, follow-up information about thyroid function and with no report of using drugs that may interfere in the thyroid function. Thyroid function was defined by TSH/FT4 levels or routine use of thyroid hormones/anti-thyroid medications. Annual and cumulative (over 4-year) incidence rates were presented as percentages (95% Confidence Intervals). Results: The incidence of all overt and subclinical thyroid disease was 6.7% (1.73%/year): 0.19% for overt hyperthyroidism (0.048%/year), 0.54% for subclinical hyperthyroidism (0.14%/year), 1.98% for overt hypothyroidism (0.51%/year), and 3.99% for subclinical hypothyroidism (1.03%/year). The incidence of all thyroid diseases was higher in women, when compared to men, with a low women:men ratio (1.36). For Blacks the highest incidence was for overt hyperthyroidism, while for Whites, the highest incidence was for overt hypothyroidism. However, the highest incidence of overt hyperthyroidism was detected in Asian descendants. The presence of antithyroperoxidase antibodies at baseline was associated with higher incidence of overt thyroid diseases. Conclusion: These results showed a high incidence of hypothyroidism, which is compatible with a country with a more-than-adequate iodine intake. The low women:men ratio of the incidence of thyroid dysfunction highlights the importance of the diagnosis of thyroid diseases among men in Brazil.

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Section: Resultsmentioning

confidence: 99%

Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Sgarbi

Janovsky

Pittito

et al. 2021

Archives of Endocrinology and Metabolism

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“…Selenium can also affect metabolic disorders through its association with thyroid hormone function [10,44]. Hypothyroxinaemia has been found to be associated with obesity [45], and a meta-analysis by Talebi et al found significantly lower levels of Se in patients with hypothyroidism compared to healthy people [46].…”

Section: Discussionmentioning

confidence: 99%

Serum Microelements in Early Pregnancy and their Risk of Large-for-Gestational Age Birth Weight

Lewandowska

Lubiński

2020

Nutrients

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Excessive birth weight has serious perinatal consequences, and it “programs” long-term health. Mother’s nutritional status can be an important element in fetal “programming”; microelements such as selenium (Se), zinc (Zn), copper (Cu), and iron (Fe) are involved in many metabolic processes. However, there are no studies assessing the relationship of the microelements in the peri-conceptual period with the risk of excessive birth weight. We performed a nested case control study of serum microelements’ levels in the 10–14th week of pregnancy and assessed the risk of large-for-gestational age (LGA) newborns using the data from a prospective cohort of pregnant women recruited in 2015–2016 in Poznań, Poland. Mothers delivering LGA newborns (n = 66) were examined with matched mothers delivering appropriate-for-gestational age (AGA) newborns (n = 264). Microelements’ levels were quantified using mass spectrometry. The odds ratios of LGA (and 95% confidence intervals) were calculated by multivariate logistic regression. In the whole group, women with the lowest quartile of Se had a 3 times higher LGA risk compared with women in the highest Se quartile (AOR = 3.00; p = 0.013). Importantly, the result was sustained in the subgroup of women with the normal pre-pregnancy BMI (AOR = 4.79; p = 0.033) and in women with a male fetus (AOR = 6.28; p = 0.004), but it was not sustained in women with a female fetus. There were no statistical associations between Zn, Cu, and Fe levels and LGA. Our study provides some preliminary evidence for the relationships between lower serum Se levels in early pregnancy and a higher risk of large-for-gestational age birth weight. Appropriate Se intake in the periconceptual period may be important for optimal fetal growth.

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“…Sample size determination was based on a parallel design randomized controlled trial where type I and II error rates were considered to be 5 and 20% (statistical power of 80%), respectively. According to a past study (Machin, Campbell, Tan, & Tan, 2018; Spaggiari et al, 2017; Talebi, Ghaedi, et al, 2019; Talebi, Karimifar, et al, 2020), we considered the minimum detectable standardized effect size for LT4 dose to be 0.8. With regard to formula, we needed a minimum of 26 participants per group.…”

Section: Methodsmentioning

confidence: 99%

“…As well, hypothyroidism is represented a potential risk of obesity (Sanyal & Raychaudhuri, 2016). Untreated hypothyroidism is linked to various clinical signs, like constipation, fatigue, weight gain, infertility, depression, and bradycardia (Gaitonde, Rowley, & Sweeney, 2012; Talebi, Ghaedi, et al, 2019; Talebi, Karimifar, Heidari, Mohammadi, & Askari, 2020). However, many patients, despite being treated with adequate thyroid hormone replacement, still experience hypothyroid‐related symptoms, affecting patient quality of life (Freeman, Adunlin, Mercadel, Danzi, & Klein, 2019).…”

Section: Introductionmentioning

confidence: 99%

The effect of synbiotic supplementation on anthropometric indices, appetite, and constipation in people with hypothyroidism: A randomized, double‐blind, placebo‐controlled trial

Karimifar

Heidari

Mohammadi

et al. 2020

Phytotherapy Research

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Hypothyroidism and obesity are two highly prevalent conditions that appear to be closely related. Hypothyroidism is correlated with weight gain, loss of appetite, constipation, and a higher incidence of obesity. The present study aimed to investigate the effects of synbiotic supplementation on anthropometric indices, appetite, and constipation in subjects with hypothyroidism. Sixty subjects with hypothyroidism were assigned into two groups to receive either 500 mg/day of synbiotic (n = 30) or a placebo (n = 30) per day for 8 weeks. Anthropometric indices, appetite, and constipation were assessed at study baseline and end of the trial. At the end of trial, waistto-hip ratio was significantly decreased in the synbiotic group (p = .030), whereas there were no significant differences between groups. We did not observe any statistically significant change in appetite or other anthropometric indices (p > .05). Compared with the placebo synbiotic supplementation led to a significant reduction in constipation (p = .048). The results of the present trial indicated that synbiotic supplementation may have favorable results in constipation among subjects with hypothyroidism for 8 weeks. Further studies with larger sample size and longer duration are needed to confirm our findings.

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Trace Element Status and Hypothyroidism: A Systematic Review and Meta-analysis

Abstract: This document is the author's post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

Cited by 52 publications

References 52 publications

Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Serum Microelements in Early Pregnancy and their Risk of Large-for-Gestational Age Birth Weight

The effect of synbiotic supplementation on anthropometric indices, appetite, and constipation in people with hypothyroidism: A randomized, double‐blind, placebo‐controlled trial

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