Trace Element Nutrition and Bone Metabolism

Beattie, John; Avenell, Alison

doi:10.1079/nrr19920013

Cited by 172 publications

(112 citation statements)

References 182 publications

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“…Alkaline phosphatase cofactor; antioxidant and superoxide dismutase (SOD) cofactor (730,731) ; skeletal growth and maturation, and bone metabolism (732) ; chemical inactivator (46) ; formation of active carcinogenic compounds (93) ; Zn-binding compounds and cancer cell death (733) ; oesophagus cancer (734) ; Zn sensing receptor and cell signalling (735) ; immune functions (736) ; inflammatory diseases and cell signalling mechanisms (737) ; type 2 diabetes (738) ; food intake (739) Mn (569,700) : Antioxidant (740) ; metalloenzyme constituent and enzyme activation (569) ; bone health (732,741) ; manganese-SOD, NFkB activation and carcinogenic process (742) ; manganese-SOD and tumour growth (743) Cu (204,700) : Antioxidant (744) ; Cu-containing/binding proteins (569) ; bone health (732,745) ; central nervous system dysfunction (700) ; immune and cardiac dysfunctions (700,746,747) ; heart health (748,749) ; anti-cancer effect and DNA binding (750) ; risk of CHD (751,752) Se (204) :…”

Section: Appendixmentioning

confidence: 99%

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

2010

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Epidemiological studies have clearly shown that whole-grain cereals can protect against obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety, reduced transit time and glycaemic response), fibre (improved faecal bulking and satiety, viscosity and SCFA production, and/or reduced glycaemic response) and Mg (better glycaemic homeostasis through increased insulin secretion), together with the antioxidant and anti-carcinogenic properties of numerous bioactive compounds, especially those in the bran and germ (minerals, trace elements, vitamins, carotenoids, polyphenols and alkylresorcinols), are today well-recognised mechanisms in this protection. Recent findings, the exhaustive listing of bioactive compounds found in whole-grain wheat, their content in whole-grain, bran and germ fractions and their estimated bioavailability, have led to new hypotheses. The involvement of polyphenols in cell signalling and gene regulation, and of sulfur compounds, lignin and phytic acid should be considered in antioxidant protection. Whole-grain wheat is also a rich source of methyl donors and lipotropes (methionine, betaine, choline, inositol and folates) that may be involved in cardiovascular and/or hepatic protection, lipid metabolism and DNA methylation. Potential protective effects of bound phenolic acids within the colon, of the B-complex vitamins on the nervous system and mental health, of oligosaccharides as prebiotics, of compounds associated with skeleton health, and of other compounds such as a-linolenic acid, policosanol, melatonin, phytosterols and para-aminobenzoic acid also deserve to be studied in more depth. Finally, benefits of nutrigenomics to study complex physiological effects of the 'whole-grain package', and the most promising ways for improving the nutritional quality of cereal products are discussed. Whole-grain wheat: Bioactive compounds: Physiological mechanisms: Health IntroductionThere is growing evidence that whole-grain cereal products protect against the development of chronic diseases. The most important of these in terms of public health are obesity (1,2) , the metabolic syndrome (3,4) , type 2 diabetes (5,6) , CVD (7) and cancers (8 -12) . Whole-grain cereal consumption has also been shown to be protective against mortality, as was shown with inflammation-related death (i.e. noncardiovascular and non-cancer inflammatory diseases such as, for example, respiratory system diseases) (13) and with cancer and CVD (4,14,15) . These conclusions are supported by the effects of consuming refined cereal products (bread, pasta and rice), as these have been associated with an increased risk of digestive tract, pharynx, larynx and thyroid cancers in northern Italians (16) . However, an association between a lower risk of developing a chronic disease and a high whole-grain cereal consumption does not mean a direct causal relationship and provides no information about the physiological mechanisms involved.These metabolic diseases are related to our daily lifestyle, no...

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Section: Appendixmentioning

confidence: 99%

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

2010

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“…Increasing evidence in the literature indicates that the secretion of these therapeutic ions from engineered biomaterials facilitate bone healing process by supplying more appropriate environment to cell proliferation, differentiation and gene expression (16)(17). Sr has an opposite effect on bone homeostasis.…”

Section: Characterization Of Mmt-pcl Composite Scaffoldsmentioning

confidence: 99%

Preparation and Characterization of Montmorillonite/Polycaprolactone Composite Scaffold Containing Strontium for Bone Tissue Engineering Studies

Demir

2016

Journal of the Turkish Chemical Society, Section A: Chemistry

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Abstract:In this study, composite scaffolds containing strontium-modified MMT and polycaprolactone (SrMMT-PCL) were prepared by using particulate leaching technique. The macrostructure and morphology of composite scaffolds were characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The released amount of Sr 2+ from scaffolds into cell culture medium was examined by inductive coupled plasma optical emission spectrometer (ICP-OES). The pore size distribution of scaffolds was determined by mercury intrusion porosimetry. The mechanical properties of the scaffolds were also evaluated. The results of XRD confirmed intercalation of PCL into MMT layers. TGA studies concluded that the MMT in PCL promoted the thermal degradation of the matrix. ICP results showed that Sr 2+ was released from composite scaffolds. The majority of pore volume seems to be occupied by pores around 250-350 µm. SEM observations demonstrated the macroporous structure of the composite scaffolds obtained by using the particulate leaching method. As a result, the gained data suggest that obtained tissue-engineered scaffold has the potential to serve as a suitable template for bone tissue engineering applications.

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“…A large number of trace elements affect longitudinal growth and bone metabolism (Beattie & Avenell, 1992), but for the purposes of the present review we will confine attention to the major influences on the growth plate.…”

Section: Trace Elementsmentioning

confidence: 99%

Micronutrients and longitudinal growth

Loveridge¹

1993

Proc. Nutr. Soc.

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Trace Element Nutrition and Bone Metabolism

Cited by 172 publications

References 182 publications

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

Preparation and Characterization of Montmorillonite/Polycaprolactone Composite Scaffold Containing Strontium for Bone Tissue Engineering Studies

Micronutrients and longitudinal growth

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