Trace element nanoparticles improved diabetes mellitus; a brief report

Introduction: Hyperglycemia in people with diabetes mellitus and its lack of control are associated with irreversible consequences. Glycation of proteins and enzymes, especially antioxidant enzymes in uncontrolled diabetes mellitus, affects these consequences. Consumption of bioactive compounds containing antioxidants and minerals as well as the use of adjunct therapies, such as cold atmospheric plasma therapy, can be effective in preventing and controlling the consequences of diabetes mellitus.Objective: In this research, we investigated whether cold plasma treatment of diabetic samples was effective in altering the activity of oxidative enzymes, some biochemical elements, and biochemical parameters.Methods: Thirty individuals with type 2 diabetes mellitus and 30 healthy individuals, as controls, participated in the study. The samples were exposed to cold argon plasma jet for 10 minutes (by a 10 kHz pulsed DC power supply with an amplitude up to 20.0 kV). The following contents of the serum samples of all participants were evaluated according to the instructions of the used kits before and after the cold argon plasma jet treatment: the activity of catalase, superoxide dismutase, and glutathione peroxidase enzymes; the concentration of glucose, hydrogen peroxide, and selenium binding protein 1 (as an indicator of blood selenium); and the concentration of copper, zinc, iron, and magnesium.Results: The activity of antioxidant enzymes and minerals significantly increased in diabetic samples treated with cold plasma (P value < 0.05). No significant changes were observed in the concentrations of glucose, hydrogen peroxide, or selenium binding protein 1 in diabetic samples treated with cold plasma.Conclusions: Using cold argon plasma jet as an adjunct method, which will reduce the glycation of enzymes and improve some minerals, can reduce the risk of diabetes complications in patients with diabetes mellitus.Keywords:Antioxidant enzymes, Cold plasma, Diabetes mellitus, Minerals.

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“…In summation, some of the minerals, trace elements, and antioxidants in bioactive compounds have antidiabetic effects [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

The effect of cold plasma on antioxidant enzymes, minerals, and some of the levels of the biochemical parameters in the subjects with type 2 diabetes mellitus samples

Martirosyan¹,

Ghomi

Ashoori

et al. 2021

BCHD

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“…As an important trace element in human, copper participates in different biological processes, including mitochondrial respiration and antioxidant defense [ 32 ]. It has been shown that copper nanoparticles have antioxidant and free radical scavenging ability and improve cardiovascular function in diabetic mice [ 33 ]. As a trace element, zinc participates in cell division, immune response, and the control of insulin secretion.…”

Section: Discussionmentioning

confidence: 99%

Effects of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Selenium Distribution in Mice Model with Type 1 Diabetes

Xing

Zhou

Wang

et al. 2022

Biol Trace Elem Res

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The effect of selenium on diabetes is significant. As pharmaceutical chaperones, tauroursodeoxycholic acid (TUDCA) and 4-phenylbutyric acid (4-PBA) can effectively improve the oxidative stress of the endoplasmic reticulum. This study established a mice model with type 1 diabetes (T1D) to evaluate the effects of pharmaceutical chaperones on selenium distribution. Streptozotocin was used to induce Friend virus B-type mice to establish a T1D mice model. Mice were administered with TUDCA or 4-PBA. Selenium levels in different tissues were measured by inductively coupled plasma-mass spectroscopy (ICP-MS). After treatment with TUDCA and 4-PBA, related laboratory findings such as glucose and glycated serum protein were significantly reduced and were closer to normal levels. At 2 weeks, 4-PBA normalized selenium levels in the heart, and 4-PBA and TUDCA maintained the selenium in the liver, kidney, and muscle at normal. At 2 months, 4-PBA and TUDCA maintained the selenium in the heart, liver, and kidney at normal levels. The serum selenium had a positive correlation with zinc and copper in the diabetes group and the control group, while the serum selenium had no significant association with magnesium and calcium at 2 weeks and 2 months. TUDCA and 4-PBA have crucial effects on selenium distribution in diabetic mice, and further research is needed to research their internal mechanisms.

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“…Furthermore, metal NPs seem to be less harmful compared to mineral salts and have a multifunctional effect on the organism. [63]…”

Section: Biological Applications Of Nps For Diabetesmentioning

confidence: 99%

Untitled

2024

IJGP

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Diabetes mellitus is a prevalent metabolic syndrome that is associated with high blood glucose levels. When diet and exercise fail to control hyperglycemia, patients are forced to start therapy with antidiabetic agents. These drugs cause several drawbacks that can affect the course of treatment; however, due to the side effects of these drugs, plant extract and bioactive compounds with antidiabetic properties are gaining as alternative treatment for diabetes. Natural products are biocompatible, cheaper, and expected to cause few side effects and patient compliance to therapy is reduced. Over the past few years', nanotechnology has found in the development of novel delivery modalities that effectively enhance antidiabetic regimen efficacy. Efforts have been targeted toward the protection of the drug by encapsulating it into a nanocarrier system and efficiently release the drug in a gradual as well as controllable manner. These systems have been applied to overcome the limitations and improve the efficacy of plant-based antidiabetic drugs. The main challenges in the formulations of plant-based nanocarriers are the loading capacity of the plant extract and the stability of the carriers. A special emphasis is placed on metallic nanoparticles with their advantages and associated complications being reported to high light their effectiveness for treating hyperglycemia. The additional inputs of nanotechnological approaches regarding exploration of herbal potential may lead to certain novel drug molecules and act as an advantage in management of diabetes for betterment of mankind.

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Trace element nanoparticles improved diabetes mellitus; a brief report

Cited by 17 publications

References 10 publications

The effect of cold plasma on antioxidant enzymes, minerals, and some of the levels of the biochemical parameters in the subjects with type 2 diabetes mellitus samples

The effect of cold plasma on antioxidant enzymes, minerals, and some of the levels of the biochemical parameters in the subjects with type 2 diabetes mellitus samples

Effects of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Selenium Distribution in Mice Model with Type 1 Diabetes

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