Trace Element Levels in Hashimoto Thyroiditis Patients with Subclinical Hypothyroidism

Erdal, Muhammed; Şahi̇n, Mustafa; Haşimi, Adnan; Üçkaya, Gökhan; Kutlu, Mustafa; Sağlam, Kenan

doi:10.1007/s12011-008-8117-8

Cited by 51 publications

(52 citation statements)

References 29 publications

(37 reference statements)

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“…Our results indicating a significant inverse relationship between serum selenium and hsCRP are in agreement with literature [16,17,29]. We found also significant negative correlation between serum selenium and HOMA-IR.…”

Section: Discussionsupporting

confidence: 93%

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Selenium Levels in First-Degree Relatives of Diabetic Patients

Özkaya

Şahi̇n

Çakal

et al. 2008

Biol Trace Elem Res

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The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR) according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 +/- 5.9 vs 88.7 +/- 8.7 microg/dl, p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 +/- 0.9 vs 0.63 +/- 0.4 mg/dL, p < 0.0001; 2.07 +/- 0.84 vs 1.51 +/- 0.69, p < 0.0001; 9.26 +/- 3.8 vs 6.8 +/- 2.98 microU/MI, p < 0.0001; 15.7 +/- 7.4 vs 11.5 +/- 5.1 micromol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = - 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = -0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine levels in individuals with selenium levels < 80 microg/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels >or= 80 (n = 91; 1.23 +/- 0.98 vs 0.81 +/- 0.76 mg/dL, p < 0.003; 1.99 +/- 0.88 vs 1.64 +/- 0.74, p < 0.005; 15.0 +/- 7.6 vs 12.9 +/- 5.7 micromol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR.

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Section: Discussionsupporting

confidence: 93%

“…It is reported that the intake of certain trace elements from supplements is associated with lower CRP concentrations in women [16]. Strong correlations between sensitive CRP and selenium have been reported [16,17]. Plasma selenium levels also found to be correlated positively with insulin resistance [18].…”

Section: Introductionmentioning

confidence: 95%

Selenium Levels in First-Degree Relatives of Diabetic Patients

Özkaya

Şahi̇n

Çakal

et al. 2008

Biol Trace Elem Res

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“…Similarly, Aihara et al [26] did not observe a significant difference in plasma zinc levels between patients with thyroid diseases (hyperthyroidism, hypothyroidism, euthyroidism with previous hyper-or hypothyroidism) and healthy controls. According to Erdal et al [27], there were no significant differences for Zn and Cu between healthy controls and patients with subclinical hypothyroidism. Moncayo et al [28] failed to demonstrate any significant association between serum Zn levels and immunogenic thyroid disease or subacute thyroiditis.…”

Section: Discussionmentioning

confidence: 94%

“…Recently, Moncayo et al [28] revealed significantly decreased serum selenium levels in patients with follicular and papillary thyroid carcinoma and in subjects with subacute silent thyroiditis. Furthermore, Erdal et al [27] observed significantly lower basal levels of serum selenium in patients with subclinical hypothyroidism [23,[33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Thyroid Disorders—Assessments of Trace Elements, Clinical, and Laboratory Parameters

Przybylik-Mazurek

Zagrodzki

Kuźniarz-Rymarz

et al. 2010

Biol Trace Elem Res

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The trace elements studied in this work (Se, Cu, Zn) are the essential constituents or cofactors required to activate numerous enzymes and proteins, playing crucial role in various physiological processes. The disturbed levels of abovementioned elements may adversely affect the endocrine system, resulting in various thyroid disorders among other upsets. The aim of this study was to investigate possible associations between them and parameters of redox balance, thyroid function indices as well as clinical records (duration of disease and therapy, lag time between thyroid surgery and this study examination, LT4 dosage) in patients with different thyroid disorders, including malignant diseases of the gland. In the group of patients with papillary carcinoma, we found a statistically significant higher Cu concentration compared with controls and patients with Hashimoto disease. In the same groups, the parameter of Zn/Cu ratio demonstrated reciprocally arranged statistically significant differences. For the group of papillary cancer patients, there was a negative correlation between lag time since thyroid operation and GPX3 activity. Our data support hypothesis of indirect involvement of Zn and Cu in thyroid regulation. For selenium, lack of simple correlation between its serum level and thyroid indices implies the need for further research on other selenium status parameters more adequately depicting changes in endocrine system.

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“…It is not always appreciated that ID is common in people with AITD owing to the frequent co-morbidity of other autoimmune conditions such as coeliac disease (41)(42)(43) and autoimmune gastritis (44)(45)(46)(47) that often cause ID. Patients with subclinical hypothyroidism or HT frequently have lower serum iron concentration and a higher prevalence of ID than do healthy controls (48,49) . A symbiotic relationship exists between active thyroid hormone concentration and the formation of erythrocytes; T3 is needed to stimulate the proliferation of erythrocyte precursors, both directly and by enhancing the production of erythropoietin (50) .…”

Section: Co-morbidity Of Autoimmune Thyroid Disease and Other Autoimmmentioning

confidence: 99%

Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease

2018

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Hashimoto's thyroiditis (HT) and Graves' disease (GD) are examples of autoimmune thyroid disease (AITD), the commonest autoimmune condition. Antibodies to thyroid peroxidase (TPO), the enzyme that catalyses thyroid-hormone production and antibodies to the receptor for the thyroid-stimulating hormone, are characteristic of HT and GD, respectively. It is presently accepted that genetic susceptibility, environmental factors, including nutritional factors and immune disorders contribute to the development of AITD. Aiming to investigate the effect of iodine, iron and selenium in the risk, pathogenesis and treatment of thyroid disease, PubMed and the Cochrane Library were searched for relevant publications to provide a narrative review. Iodine: chronic exposure to excess iodine intake induces autoimmune thyroiditis, partly because highly-iodinated thyroglobulin (Tg) is more immunogenic. The recent introduction of universal salt iodisation can have a similar, although transient, effect. Iron: iron deficiency impairs thyroid metabolism. TPO is a haem enzyme that becomes active only after binding haem. AITD patients are frequently iron-deficient since autoimmune gastritis, which reduces iron absorption and coeliac disease which causes iron loss, are frequent co-morbidities. In two-thirds of women with persistent symptoms of hypothyroidism despite appropriate levothyroxine therapy, restoration of serum ferritin above 100 µg/l ameliorated symptoms. Selenium: selenoproteins are essential to thyroid action. In particular, the glutathione peroxidases remove excessive hydrogen peroxide produced there for the iodination of Tg to form thyroid hormones. There is evidence from observational studies and randomised controlled trials that selenium, probably as selenoproteins, can reduce TPO-antibody concentration, hypothyroidism and postpartum thyroiditis. Appropriate status of iodine, iron and selenium is crucial to thyroid health.

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Trace Element Levels in Hashimoto Thyroiditis Patients with Subclinical Hypothyroidism

Cited by 51 publications

References 29 publications

Selenium Levels in First-Degree Relatives of Diabetic Patients

Selenium Levels in First-Degree Relatives of Diabetic Patients

Thyroid Disorders—Assessments of Trace Elements, Clinical, and Laboratory Parameters

Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease

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