Trace element concentrations in renal cell carcinoma

Karcioglu, Zeynel A.; Sarper, R.; Rinsvelt, H.A. Van; Guffey, J. A.; Fink, R.W.

doi:10.1002/1097-0142(197809)42:3<1330::aid-cncr2820420344>3.0.co;2-z

Cited by 30 publications

(9 citation statements)

References 43 publications

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“…The zinc levels in both types of neoplastic tissue were found to be ≈ 60% lower than that from normal eyes. Although the data in that study were consistent with other studies that demonstrated considerable reductions of zinc content in malignant tissues, reports of elevated zinc levels in cancerous organs have also been made 30 –33 . To date, no causal relationship has been made between any altered level of dietary zinc and oncogenesis.…”

Section: Discussionsupporting

confidence: 88%

The influence of aging and low zinc nutrition on the choroid in the pig: I. The melanocyte

Lewis²,

MacKay³

et al. 1999

Veterinary Ophthalmology

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The effects of low zinc nutrition and aging on central choroidal melanocytes were examined in the pig. Three populations of pigs (young, pregnant and aged), were maintained on either control (C) or low zinc (LZ) diets. Twenty-five weanling boars were sacrificed at 2, 4, 8, 10, and 12-month intervals, and nine pregnant sows and eight aged sows were sacrificed after a 6-month interval. Melanocytes of the central choroid were morphologically and morphometrically examined. The melanocyte was found to be conservative in its form, which was mostly elliptical longitudinal profile, throughout the different age populations that were fed the C diet. Morphometric observations revealed that this cell type increased in size in the oldest animals, having been 40% greater than that in the younger two populations. However, the overall percentage area occupied by melanocytes remained the same throughout all age groups. In the animals that were fed the LZ diets, a large subpopulation of choroidal melanocytes was oval to round in shape in the pregnant and aged groups. Many members of this subpopulation possessed less opaque pigment than the elliptically shaped cell. Measurements of the size and percentage area occupied in these oldest groups increased significantly. In addition to the change of size, shape and melanin opaqueness, unusually large melanosomes were consistently observed in the pregnant and aged LZ groups. Low zinc nutrition had a remarkable age-related impact on the usually quiescent melanocyte.

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Section: Discussionsupporting

confidence: 88%

The influence of aging and low zinc nutrition on the choroid in the pig: I. The melanocyte

Lewis²,

MacKay³

et al. 1999

Veterinary Ophthalmology

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“…Iron is required as a cofactor for the catalytic activity of HPHs [6], and is also a pivotal nutrient for cell growth and cell cycle regulation [7]. Furthermore, it has been reported that iron is more abundant in RCC tissues than in non-tumor tissues [8]. Although we did not examine tumor and non-tumor tissue iron levels, hepcidin mRNA expression was higher in the RCCs with metastasis than in those without metastasis, indicating that an increase of hepcidin mRNA expression might be associated with elevation of the iron content in tumor cells.…”

Section: Discussionmentioning

confidence: 99%

“…Iron is a pivotal nutrient for cell growth and cell cycle regulation, so iron chelators may be useful for the treatment of cancer [7]. It has been reported that iron is more abundant in RCCs than in the surrounding non-tumor tissues [8]. Therefore, it is of interest to investigate the factors that modulate iron metabolism in RCC.…”

Section: Introductionmentioning

confidence: 99%

Increased serum hepcidin-25 level and increased tumor expression of hepcidin mRNA are associated with metastasis of renal cell carcinoma

et al. 2009

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BackgroundHepcidin has an important role in iron metabolism. We investigated whether hepcidin was involved in renal cell carcinoma (RCC).MethodsWe measured serum hepcidin-25 levels in 32 patients by liquid chromatograpy (LC)-mass spectrometry (MS)/MS, and assessed hepcidin mRNA expression in paired tumor and non-tumor tissue samples from the surgical specimens of 53 consecutive patients with RCC by real-time reverse transcription polymerase chain reaction.ResultsThe serum hepcidin-25 level was higher in patients with metastatic RCC than nonmetastatic RCC (P < 0.0001), and was positively correlated with the serum interleukin-6 and C-reactive protein levels (P < 0.001). Expression of hepcidin mRNA was lower in tumor tissues than in non-tumor tissues (P < 0.0001). The serum hepcidin-25 level was not correlated with the expression of hepcidin mRNA in the corresponding tumor tissue specimens from 32 patients. Hepcidin mRNA expression in tumor tissue was correlated with metastatic potential, but not with histological differentiation or tumor stage. Kaplan-Meier analysis showed that over expression of hepcidin mRNA was related to shorter overall survival in RCC patients. Univariate analysis (Cox proportional hazards model) showed that the hepcidin mRNA level was an independent prognostic factor for overall survival.ConclusionOur findings suggest that a high serum hepcidin-25 level may indicate the progression of RCC, and that upregulation of hepcidin mRNA expression in tumor tissue may be related to increased metastatic potential.

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“…Additionally, high serum copper levels may be associated with an increased risk for several types of cancer, e.g., lung cancer, neoplastic kidney tissue, leukaemia and hepatocellular carcinoma (Hrgovcic et al, 1973;Karcioglu et al, 1978;Mateo et al, 1979;Poo et al, 2003). Though, whether high copper levels are a cause or "bystander" effect of these malignancies is still under investigation.…”

Section: Copper Toxicity In Age-related Diseases and Wilson Diseasementioning

confidence: 99%

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Giorgi

Marchi

Simões

et al. 2018

International Review of Cell and Molecular Biology

270

162

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Aging has been linked to several degenerative processes that, through the accumulation of molecular and cellular damage, can progressively lead to cell dysfunction and organ failure. Human aging is linked with a higher risk for individuals to develop cancer, neurodegenerative, cardiovascular, and metabolic disorders. The understanding of the molecular basis of aging and associated diseases has been one major challenge of scientific research over the last decades. Mitochondria, the center of oxidative metabolism and principal site of reactive oxygen species (ROS) production, are crucial both in health and in pathogenesis of many diseases. Redox signaling is important for the modulation of cell functions and several studies indicate a dual role for ROS in cell physiology. In fact, high concentrations of ROS are pathogenic and can cause severe damage to cell and organelle membranes, DNA, and proteins. On the other hand, moderate amounts of ROS are essential for the maintenance of several biological processes, including gene expression. In this review, we provide an update regarding the key roles of ROS-mitochondria cross talk in different fundamental physiological or pathological situations accompanying aging and highlighting that mitochondrial ROS may be a decisive target in clinical practice.

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Trace element concentrations in renal cell carcinoma

Cited by 30 publications

References 43 publications

The influence of aging and low zinc nutrition on the choroid in the pig: I. The melanocyte

The influence of aging and low zinc nutrition on the choroid in the pig: I. The melanocyte

Increased serum hepcidin-25 level and increased tumor expression of hepcidin mRNA are associated with metastasis of renal cell carcinoma

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

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