Trace antibiotics increase the risk of antibiotic resistance genes transmission by regulating the biofilm extracellular polymeric substances and microbial community in the sewer

Xin, Kuan; Chen, Xingdu; Zhang, Zigeng; Zhang, Zhiqiang; Pang, Heliang; Yang, Jing; Jiang, Hui; Lu, Jinsuo

doi:10.1016/j.jhazmat.2022.128634

Cited by 45 publications

(4 citation statements)

References 80 publications

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“…2,3 Unfortunately, long-term exposure to low doses of SMX can induce mass reproduction of antibioticresistant bacteria and transmission resistance genes. 4,5 Thus, it is urgent to develop an effective technology for removing SMX from natural water bodies.…”

Section: Introductionmentioning

confidence: 99%

“…The excessive abuse and uncontrolled discharges of antibiotics pose a severe threat to ecological safety and public health. Sulfamethoxazole (SMX), classified as one of the top 10 priority drugs in European countries, has been frequently detected in various water bodies with an average concentration of 0.01–2.0 μg/L. , Unfortunately, long-term exposure to low doses of SMX can induce mass reproduction of antibiotic-resistant bacteria and transmission resistance genes. , Thus, it is urgent to develop an effective technology for removing SMX from natural water bodies.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MoS₂ Nanosheets Anchored onto MIL-100(Fe)-Derived FeS₂ as a Peroxymonosulfate Activator for Efficient Sulfamethoxazole Degradation: Insights into the Mechanism

et al. 2022

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By anchoring MoS2 nanosheets onto FeS2 derived from different MIL-100(Fe) precursors, a series of FeS2@MoS2-x samples featuring sulfur vacancies (SVs) were prepared as efficient peroxymonosulfate (PMS) activators to degrade sulfamethoxazole (SMX) from aqueous solution. Benefiting from the strongly reductive sulfur species (S2– and S2 2–), enriched Mo(IV) sites, and abundant SVs, 40 μM SMX was completely removed by the FeS2@MoS2-2/PMS system in 7 min (0.2 g/L FeS2@MoS2-2, 0.25 mM PMS). The k obs obtained by FeS2@MoS2-2 was 0.598 min–1, which was 5.8 and 51.1 times higher than that of FeS2 (0.103 min–1) and MoS2 (0.012 min–1), respectively. Quenching experiments, electron paramagnetic resonance (EPR) analysis, and 18O isotope labeling tests evidenced the involvement of radical (•OH, SO4 •–) and non-radical (1O2, FeIV = O) pathways in the FeS2@MoS2-2/PMS system, and MoS2 anchoring enormously enhanced the contribution of non-radicals to 45.5%. In addition, SVs possessed favorable affinity toward PMS and dissolved oxygen (DO), promoting continuous production of reactive active species. The degradation pathways of SMX were unveiled as well. The satisfactory recyclability, stability, and universality enabled FeS2@MoS2-2 to serve as a promising candidate for PMS activation. This study provides a novel strategy to construct sulfur vacancy-featuring Fe-based sulfide catalysts using MIL-100(Fe) as sacrificial templates for activating PMS to treat refractory organic-polluted water.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MoS₂ Nanosheets Anchored onto MIL-100(Fe)-Derived FeS₂ as a Peroxymonosulfate Activator for Efficient Sulfamethoxazole Degradation: Insights into the Mechanism

et al. 2022

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“…It further induced the formation of a heterogeneous biofilm structure, which was confirmed by the analysis results in Sections and 3.2. The process was as follows: (1) Acinetobacter and Pseudomonas (dominant genera in bin 9) with strong resistance preferentially colonized the surface of the carriers (Figure a and S6); (2) the two keystone species, reported with the ability of metabolizing SMX , and mass production of EPS based on QS, ,− led to the formation of a protective microenvironment and might further mediate the assembly of small-cell aggregates as predicted by Chen et al It could be reflected by the high proportion of DLs (Figure a), i.e., higher microbial co-occurrence associations occurred when the relative importance of DL to species sorting increased . (3) Cell aggregates interlinked to form a highly heterogeneous structure .…”

Section: Resultsmentioning

confidence: 83%

Adaptive Evolution Laws of Biofilm under Emerging Pollutant-Induced Stress: Community Assembly-Driven Structure Response

Kong

Jin

Zhao

et al. 2023

Environ. Sci. Technol.

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The widely used biofilm process in advanced wastewater treatment is currently challenged by numerous exotic emerging pollutants (EPs), and the underlying principle of the challenge is the adaptive evolution laws of biofilm under EP stress. However, there is still a knowledge gap in exploration of the biofilm adaptive evolution theory. Herein, we comprehensively analyzed the morphological variation, community succession, and assembly mechanism of biofilms to report the mechanism underlying their adaptive evolution under sulfamethoxazole and carbamazepine stress for the first time. The ecological role of the dominant species was driven as a pioneer and assembly hub by EP stress, and the deterministic processes indicated the functional basis of the transformation. In addition, the characteristic responses of dispersal limitation and homogenizing dispersal adequately revealed the assembly pathways in adaptive evolution and the resulting structural variation. Therefore, the "interfacial exposure−structural variation−mass transfer feedback" mechanism was inferred to underly the adaptive evolution process of biofilms. Overall, this study highlighted the internal drivers of the adaptive evolution of the biofilm at the phylogenetic level and deepened our understanding of the mechanism of biofilm development under EP stress in advanced wastewater purification.

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“…An interesting study by Xin et al explores a world-that of the sewers-apparently far from the clinic but important in a holistic vision of medicine such as that represented by the modern concept of One Health. The mentioned study highlighted that trace antibiotics favor the transfer of antibiotic resistance genes by regulating the extracellular polymeric substances of biofilm in sewers [84].…”

Section: Can the Biofilm Formation Be Induced By Host-derived Factors?mentioning

confidence: 99%

Emerging Issues and Initial Insights into Bacterial Biofilms: From Orthopedic Infection to Metabolomics

Mirzaei,

Campoccia,

Ravaioli

et al. 2024

Antibiotics

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Bacterial biofilms, enigmatic communities of microorganisms enclosed in an extracellular matrix, still represent an open challenge in many clinical contexts, including orthopedics, where biofilm-associated bone and joint infections remain the main cause of implant failure. This study explores the scenario of biofilm infections, with a focus on those related to orthopedic implants, highlighting recently emerged substantial aspects of the pathogenesis and their potential repercussions on the clinic, as well as the progress and gaps that still exist in the diagnostics and management of these infections. The classic mechanisms through which biofilms form and the more recently proposed new ones are depicted. The ways in which bacteria hide, become impenetrable to antibiotics, and evade the immune defenses, creating reservoirs of bacteria difficult to detect and reach, are delineated, such as bacterial dormancy within biofilms, entry into host cells, and penetration into bone canaliculi. New findings on biofilm formation with host components are presented. The article also delves into the emerging and critical concept of immunometabolism, a key function of immune cells that biofilm interferes with. The growing potential of biofilm metabolomics in the diagnosis and therapy of biofilm infections is highlighted, referring to the latest research.

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Trace antibiotics increase the risk of antibiotic resistance genes transmission by regulating the biofilm extracellular polymeric substances and microbial community in the sewer

Cited by 45 publications

References 80 publications

MoS₂ Nanosheets Anchored onto MIL-100(Fe)-Derived FeS₂ as a Peroxymonosulfate Activator for Efficient Sulfamethoxazole Degradation: Insights into the Mechanism

MoS₂ Nanosheets Anchored onto MIL-100(Fe)-Derived FeS₂ as a Peroxymonosulfate Activator for Efficient Sulfamethoxazole Degradation: Insights into the Mechanism

Adaptive Evolution Laws of Biofilm under Emerging Pollutant-Induced Stress: Community Assembly-Driven Structure Response

Emerging Issues and Initial Insights into Bacterial Biofilms: From Orthopedic Infection to Metabolomics

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Trace antibiotics increase the risk of antibiotic resistance genes transmission by regulating the biofilm extracellular polymeric substances and microbial community in the sewer

Cited by 45 publications

References 80 publications

MoS2 Nanosheets Anchored onto MIL-100(Fe)-Derived FeS2 as a Peroxymonosulfate Activator for Efficient Sulfamethoxazole Degradation: Insights into the Mechanism

MoS2 Nanosheets Anchored onto MIL-100(Fe)-Derived FeS2 as a Peroxymonosulfate Activator for Efficient Sulfamethoxazole Degradation: Insights into the Mechanism

Adaptive Evolution Laws of Biofilm under Emerging Pollutant-Induced Stress: Community Assembly-Driven Structure Response

Emerging Issues and Initial Insights into Bacterial Biofilms: From Orthopedic Infection to Metabolomics

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Product

Resources

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MoS₂ Nanosheets Anchored onto MIL-100(Fe)-Derived FeS₂ as a Peroxymonosulfate Activator for Efficient Sulfamethoxazole Degradation: Insights into the Mechanism

MoS₂ Nanosheets Anchored onto MIL-100(Fe)-Derived FeS₂ as a Peroxymonosulfate Activator for Efficient Sulfamethoxazole Degradation: Insights into the Mechanism