Trabecular microfractures in the femoral head with osteoporosis: Analysis of microcallus formations by synchrotron radiation micro CT

Okazaki, Narihiro; Chiba, Ko; Taguchi, Koichi; Nango, Nobuhito; Kubota, Shogo; Ito, Masako; Osaki, Makoto

doi:10.1016/j.bone.2014.03.039

Cited by 20 publications

(15 citation statements)

References 24 publications

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“…In recent years, 3D visualization the images of microarchitecture of human and animal bone specimens at different sites were shown using SR-μCT, noninvasively and at high resolution, such as the femur, tibia and vertebrae [ 26 , 30 , 41 – 47 ]. Microarchitecture characterization of bone within different bone diseases, including osteoporosis[ 48 ], osteoarthritis[ 43 ] and bone metastases[ 42 ], have also been carried using SR-μCT, which was also used to predict bone fragility or microcracks [ 29 ]. Although the microarchitecture index could be obtained by SR-μCT, there was a lack of research for using this method as an evaluation tool to study the effects of treatment or intervention.…”

Section: Discussionmentioning

confidence: 99%

Effects of Low-Intensity Pulsed Ultrasound on New Trabecular Bone during Bone–Tendon Junction Healing in a Rabbit Model: A Synchrotron Radiation Micro-CT Study

et al. 2015

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This study was designed to evaluate the effects of low-intensity pulsed ultrasound on bone regeneration during the bone–tendon junction healing process and to explore the application of synchrotron radiation micro computed tomography in three dimensional visualization of the bone–tendon junction to evaluate the microarchitecture of new trabecular bone. Twenty four mature New Zealand rabbits underwent partial patellectomy to establish a bone–tendon junction injury model at the patella–patellar tendon complex. Animals were then divided into low-intensity pulsed ultrasound treatment (20 min/day, 7 times/week) and placebo control groups, and were euthanized at week 8 and 16 postoperatively (n = 6 for each group and time point). The patella–patellar tendon specimens were harvested for radiographic, histological and synchrotron radiation micro computed tomography detection. The area of the newly formed bone in the ultrasound group was significantly greater than that of control group at postoperative week 8 and 16. The high resolution three dimensional visualization images of the bone–tendon junction were acquired by synchrotron radiation micro computed tomography. Low-intensity pulsed ultrasound treatment promoted dense and irregular woven bone formation at week 8 with greater bone volume fraction, number and thickness of new trabecular bone but with lower separation. At week 16, ultrasound group specimens contained mature lamellar bone with higher bone volume fraction and thicker trabeculae than that of control group; however, there was no significant difference in separation and number of the new trabecular bone. This study confirms that low-intensity pulsed ultrasound treatment is able to promot bone formation and remodeling of new trabecular bone during the bone–tendon junction healing process in a rabbit model, and the synchrotron radiation micro computed tomography could be applied for three dimensional visualization to quantitatively evaluate the microarchitecture of new bone in bone–tendon junction.

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Section: Discussionmentioning

confidence: 99%

Effects of Low-Intensity Pulsed Ultrasound on New Trabecular Bone during Bone–Tendon Junction Healing in a Rabbit Model: A Synchrotron Radiation Micro-CT Study

et al. 2015

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“…BS/BV was obtained using a plate model, and DA was derived using the mean intercept length method. DA correlates with the orientation of the loading regime of the bone, and the trabecular bone in the load-bearing skeletal regions adapts to transmit compressive or tensile loads along its primary orientation [ 14 – 16 ]. These parameters are typically used to evaluate bone quality.…”

Section: Methodsmentioning

confidence: 99%

Influence of the lateral pterygoid muscle on traumatic temporomandibular joint bony ankylosis

Deng

Liu

et al. 2016

BMC Oral Health

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BackgroundThe pathogenesis of traumatic TMJ ankylosis remains unclear. This study aimed to verify the role of the lateral pterygoid muscle in the pathogenesis of traumatic temporomandibular joint (TMJ) bony ankylosis.MethodsEight 6-month-old male sheep were used in this study. Bilateral TMJ osteotomies were performed to induce sagittal fractures of the mandibular condyle. The lateral one-fourth segment of the disc was removed to establish a model of TMJ bony ankylosis. Subsequently, the function of the left and right lateral pterygoid muscles was blocked (experimental group) or maintained (control group), respectively. At 12 weeks postoperatively, animals were sacrificed and TMJ complex samples were evaluated by gross observation, spiral computed tomography (CT), micro-CT, and histological examinations.ResultsGross observation revealed bony ankylosis in the control TMJs and fibrous adhesions in the experimental TMJs. Spiral CT and micro-CT demonstrated that, compared to the experimental group, the control group showed calcified callus formation in the joint space and roughened articular surfaces after new bone formation, which protruded into the joint space. Maximum mediolateral and anteroposterior condylar diameters were significantly larger in the control group than in the experimental group. Micro-CT also showed that the primary growth orientation of new trabeculae was consistent with the direction of lateral pterygoid traction in the control group, but not in the experimental group. Histological examination showed fibro-osseous ankylosis in the control group, but not in the experimental group.ConclusionsThe lateral pterygoid simulates the effects of distraction osteogenesis, which is an important factor in the pathogenesis of TMJ bony ankylosis during the healing of sagittal condylar fractures.

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“…With the development of scanning and imaging technologies, SR‐µCT had been used in orthopedics, including in osteoarthritis, bone metastases, and osteoporosis . There are many ways to measure the micro‐architecture of bone, such as conventional µCT, SR‐µCT.…”

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confidence: 99%

The effect of low‐intensity pulsed ultrasound on bone‐tendon junction healing: Initiating after inflammation stage

Lü

Liu

Chen

et al. 2016

Journal Orthopaedic Research

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The purpose of this study was to explore the effect of low‐intensity pulsed ultrasound (LIPUS) treatment initiating after inflammation stage on the process of bone‐tendon junction (BTJ) healing in a rabbit model. Thirty‐six rabbits undergoing partial patellectomy were randomly divided into two groups: control and LIPUS. The period of initial inflammatory stage is 2 weeks. So LIPUS treatment was initiated at postoperative week 2 and continued until the patella‐patellar tendon (PPT) complexes were harvested at postoperative weeks 4, 8, and 16. At each time point, the PPT complexes were harvested for qRT‐PCR, histology, radiographs, synchroton radiation micro computed tomography (SR‐µCT), and biomechanical testing. The qRT‐PCR results showed that LIPUS treatment beginning at postoperative week 2 played an anti‐inflammatory role in BTJ healing. Histologically, the LIPUS group showed more advanced remodeling of the lamellar bone and marrow cavity than the control group. The area and length of the new bone in the LIPUS group were significantly greater than the control group at postoperative weeks 8 and 16. SR‐µCT demonstrated that new bone formation and remodeling in the LIPUS group were more advanced than the control group. Biomechanical test results demonstrated that the failure load, ultimate strength and energy at failure were significantly higher than those of the control group. In conclusion, LIPUS treatment beginning at postoperative week 2 was able to accelerate bone formation during the bone‐tendon junction healing process and significantly improved the healing quality of BTJ injury. © 2016 The Authors. Journal of Orthopaedic Research published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society.

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Trabecular microfractures in the femoral head with osteoporosis: Analysis of microcallus formations by synchrotron radiation micro CT

Cited by 20 publications

References 24 publications

Effects of Low-Intensity Pulsed Ultrasound on New Trabecular Bone during Bone–Tendon Junction Healing in a Rabbit Model: A Synchrotron Radiation Micro-CT Study

Effects of Low-Intensity Pulsed Ultrasound on New Trabecular Bone during Bone–Tendon Junction Healing in a Rabbit Model: A Synchrotron Radiation Micro-CT Study

Influence of the lateral pterygoid muscle on traumatic temporomandibular joint bony ankylosis

The effect of low‐intensity pulsed ultrasound on bone‐tendon junction healing: Initiating after inflammation stage

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