Trabecular (merkel cell) carcinoma of the skin. Treatment of primary, recurrent, and metastatic disease

Abstract

Four new patients with trabecular (Merkel cell) carcinoma of the skin are described, and an additional 76 patients from the literature are reviewed. The mean age of the combined group of patients was 68; 84% were 60 years or older. Primary tumors appeared most frequently on the head and neck (44%), leg (28%), arm (16%), or buttock (9%). No primary tumor appeared on the trunk. The rate of local recurrence was 36%, regional metastatic disease, 53%; distant metastases, 28%; and death due to metastatic tumor (minimally), 25%. It appears that trabecular carcinoma of the skin is more aggressive and lethal than previously thought. The authors recommend that patients with this tumor undergo wide resection of the primary site and, in healthy patients, prophylactic regional node dissection. Both radiation therapy and chemotherapy are effective in palliating unresectable disease.

Benefits of combined modality treatment of Merkel cell carcinoma of the head and neck: single institution experience

“…[1][2][3][4][5][6][8][9][10][11][12][13][14] Despite increasing awareness of this cancer, the optimal management of head and neck Merkel cell carcinoma remains unclear. For local disease, wide excision of the primary tumour is a well-established practice, [1][2][3][4][5][9][10][11][12][13][14][15][16][17][18][19][20][21][22] with opinion regarding the minimum surgical margin differing somewhat. Adjuvant of local excision, margin status, and adjuvant radiotherapy and chemotherapy on locoregional recurrence and survival.…”

The role of radiation therapy and chemotherapy in the treatment of merkel cell carcinoma

“…16,17 The authors successfully used doses agents. [20][21][22] The regimens employed are similar to of 40 Gy for prophylactic irradiation and 45 Gy for those used for SCC of the lung, as based on the mormeasurable disease. phologic and immunohistochemical similarities of the MCC has traditionally been managed with surgery two tumors.…”

“…ImLocal recurrences and soft tissue metastases were proved locoregional control was reported by several auhighly responsive, and visceral disease was much less thors using postoperative irradiation to the primary site responsive. Similar to other reports, 12,13,21 response to as well as to the regional draining lymph nodes. 16,17,24 chemotherapy usually occurred early in the course of However, results from pooled data 23 emphasize that the treatment but was of short duration in the absence of major factor adversely affecting prognosis is distant disconsolidative radiotherapy.…”

Yüzde Yerleşen Dev Merkel Hücreli Karsinom

“…Tipik olarak sert, ağrısız, yuvarlak şekilli kırmızı bir nodül olarak başlamakta, yüzeyi ülsere olabilen bu nodül, bazen parlak görünümde, akneiform veya telenjiektatik özellikler gösterebilmektedir 5 9,10 . Hastalarda, başvuru anındaki bölgesel lenf nodu tutulumu %9-26, uzak metastaz ise %1-4 arasında bildirilmektedir 11 . Uzak metastazlar en sık deri, karaciğer, kemik, akciğer, beyin ve uzak lenf nodlarınadır 12 .…”