Trabecular-like Ti–6Al–4V scaffold for bone repair: A diversified mechanical stimulation environment for bone regeneration

Liang, Huixin; Chao, Long; Xie, Dexin; Yang, Youwen; Shi, Jianping; Zhang, Yun; Xue, Bin; Shen, Lida; Tian, Zongjun; Li, Lan; Jiang, Qing

doi:10.1016/j.compositesb.2022.110057

Cited by 50 publications

(10 citation statements)

References 57 publications

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“…The selection of porous materials in different parts is shown in Table 1 . Existing studies have shown that 3D printing technology can be used to prepare pore gradient scaffolds [ 6 , 30 ]. The porous structure selected in this design has been prepared by 3D printing technology and has good mechanical and biological properties, so the designed femoral scaffolds can be prepared by 3D printing technology.…”

Section: Methodsmentioning

confidence: 99%

“…Aseptic loosening is mainly caused by the failure of bone tissue to grow into the scaffold. At present, researchers focus on how to change the shape and pore size of the porous structure to make better bone tissue ingrowth [ 5 , 6 ]. The research results of Pires et al [ 7 ] showed that the triply periodic minimal surfaces were a good bone repair structure.…”

Section: Introductionmentioning

confidence: 99%

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Design and performance analysis of 3D-printed stiffness gradient femoral scaffold

Liu

Deng

et al. 2023

J Orthop Surg Res

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Studies on 3D-printed porous bone scaffolds mostly focus on materials or structural parameters, while the repair of large femoral defects needs to select appropriate structural parameters according to the needs of different parts. In this paper, a kind of stiffness gradient scaffold design idea is proposed. Different structures are selected according to the different functions of different parts of the scaffold. At the same time, an integrated fixation device is designed to fix the scaffold. Finite element method was used to analyze the stress and strain of homogeneous scaffolds and the stiffness gradient scaffolds, and the relative displacement and stress between stiffness gradient scaffolds and bone in the case of integrated fixation and steel plate fixation. The results showed that the stress distribution of the stiffness gradient scaffolds was more uniform, and the strain of host bone tissue was changed greatly, which was beneficial to the growth of bone tissue. The integrated fixation method is more stable, less stress and evenly distributed. Therefore, the integrated fixation device combined with the design of stiffness gradient can repair the large femoral bone defect well.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design and performance analysis of 3D-printed stiffness gradient femoral scaffold

Liu

Deng

et al. 2023

J Orthop Surg Res

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“…Bone minerals provide stiffness and strength, while collagen provides ductility and the crucial ability to absorb energy before fracturing [ 21 ]. Therefore, bound water shows the viscoelastic characteristics of general liquid, and trabecular bone reflects the elastic characteristics [ 22 , 23 ]. To describe this unique structure, a mechanical model should be used to describe both the liquid and solid.…”

Section: Methodsmentioning

confidence: 99%

Mechanical Behavior of Human Cancellous Bone in Alveolar Bone under Uniaxial Compression and Creep Tests

Liu

et al. 2022

Materials

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In the process of orthodontic treatment, the remodeling of cancellous bone in alveolar bone (in this paper, cancellous bone in alveolar bone is abbreviated as CBAB) is key to promoting tooth movement. Studying the mechanical behavior of CBAB is helpful to predict the displacement of teeth and achieve the best effect of orthodontic treatment. Three CBAB samples were cut from alveolar bone around the root apex of human teeth. A uniaxial compression test was used to study the transient elastic properties of CBAB. A creep test was used to study the time-dependent viscoelastic properties of CBAB. Both tests were carried out at the loading rates of 0.02 mm/min, 0.1 mm/min and 0.5 mm/min. The results revealed that CBAB is a nonlinear viscoelastic and hyperelastic material. The stress–strain curve obtained from the uniaxial compression test could be divided into three stages: the collapse stage of the front section, the exponential stage of the middle section and the almost linear stage of the rear end. According to the strain–time curve obtained from the compression creep test, a trend of increasing strain over time was relatively obvious within the first 30 s. After 200 s, the curve gradually tended to plateau. Four hyperelastic models and three viscoelastic models were used to fit the test data. Finally, the fifth-order polynomial hyperelastic model (coefficient of determination “R2 > 0.999”) was used to describe the hyperelastic properties of CBAB, and the seven-parameter model of the generalized Kelvin modified model (“R2 > 0.98”) was used to describe the viscoelastic properties of CBAB.

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“…The high density can explain the improvement in the mechanical strength and grain refinement of the L-PBF specimens; therefore, the material strength substantially increases according to the Hall-Petch slope equation ( Guan et al, 2019 ). Li et al (2018b) investigated the biomechanical effects of the different crystal structures of WE43 alloy porous scaffolds fabricated using L-PBF and found that porous WE43 scaffolds with diamond structural units provided adequate mechanical support with mechanical properties comparable to those of bone trabeculae even after 4 weeks of immersion in SBF. Shuai et al (2017b) reported that the grain sizes of L-PBF-formed Mg alloy samples were 2, 4, 6, and 8 μm at the Ev values of 420, 500, 600, and 750 J/mm 3 , respectively.…”

Section: Current Status Of the Biomechanical Properties Of Am Mg Allo...mentioning

confidence: 99%

Comprehensive review of additively manufactured biodegradable magnesium implants for repairing bone defects from biomechanical and biodegradable perspectives

et al. 2022

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Bone defect repair is a complicated clinical problem, particularly when the defect is relatively large and the bone is unable to repair itself. Magnesium and its alloys have been introduced as versatile biomaterials to repair bone defects because of their excellent biocompatibility, osteoconductivity, bone-mimicking biomechanical features, and non-toxic and biodegradable properties. Therefore, magnesium alloys have become a popular research topic in the field of implants to treat critical bone defects. This review explores the popular Mg alloy research topics in the field of bone defects. Bibliometric analyses demonstrate that the degradation control and mechanical properties of Mg alloys are the main research focus for the treatment of bone defects. Furthermore, the additive manufacturing (AM) of Mg alloys is a promising approach for treating bone defects using implants with customized structures and functions. This work reviews the state of research on AM-Mg alloys and the current challenges in the field, mainly from the two aspects of controlling the degradation rate and the fabrication of excellent mechanical properties. First, the advantages, current progress, and challenges of the AM of Mg alloys for further application are discussed. The main mechanisms that lead to the rapid degradation of AM-Mg are then highlighted. Next, the typical methods and processing parameters of laser powder bed fusion fabrication on the degradation characteristics of Mg alloys are reviewed. The following section discusses how the above factors affect the mechanical properties of AM-Mg and the recent research progress. Finally, the current status of research on AM-Mg for bone defects is summarized, and some research directions for AM-Mg to drive the application of clinical orthopedic implants are suggested.

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Trabecular-like Ti–6Al–4V scaffold for bone repair: A diversified mechanical stimulation environment for bone regeneration

Cited by 50 publications

References 57 publications

Design and performance analysis of 3D-printed stiffness gradient femoral scaffold

Design and performance analysis of 3D-printed stiffness gradient femoral scaffold

Mechanical Behavior of Human Cancellous Bone in Alveolar Bone under Uniaxial Compression and Creep Tests

Comprehensive review of additively manufactured biodegradable magnesium implants for repairing bone defects from biomechanical and biodegradable perspectives

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