Trabecular Bone Score in Rheumatic Disease

Richards, Ceri; Leslie, William D.

doi:10.1007/s11926-022-01062-w

Cited by 11 publications

(8 citation statements)

References 48 publications

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“…The mechanism underlying this association has not previously been elucidated, but might be related, at least in part, to the inflammatory nature of HS. This would be in line with previous research assessing TBS and BMD in patients with other inflammatory conditions, such as RA, psoriasis, and systemic lupus erythematosus ( 12 , 25 , 26 ). Thus, TBS has been assessed in several rheumatic diseases and values consistent with degraded microarchitecture have been related to disease activity in patients with ankylosing spondylitis, systemic sclerosis, and RA ( 13 ).…”

Section: Discussionsupporting

confidence: 90%

Bone Metabolism in Patients with Hidradenitis Suppurativa: A Case-control Study

et al. 2022

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Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicles. The aim of this case-control study was to assess whether HS is associated with disturbances in trabecular bone score, bone mineral density, bone remodelling markers, and calciotropic hormones. A total of 81 patients and 79 controls of similar age and sex were included. Demographic, anthropometric, laboratory data, trabecular bone score, bone mineral density, serum 25-hydroxyvitamin D (25OHD), serum amino-terminal pro-peptide of type 1 collagen (PINP), and C-terminal telopeptide of type 1 collagen (CTX) concentrations were assessed in both groups. Patients with HS had lower serum 25OHD levels than controls, and approximately 62% of them had vitamin D deficiency. Serum PINP was increased and CTX was decreased in patients with HS. Fully adjusted trabecular bone score values were lower in patients with HS compared with controls. Adjusted lumbar bone mineral density was similar in HS and controls, whilst total hip bone mineral density was lower in patients with HS. There were no statistical differences regarding disease severity in terms of 25OHD, serum turnover markers, bone mineral density, or trabecular bone score values. This study shows that patients with HS have lower trabecular bone score and total hip bone mineral density values than population-based controls. In addition, the prevalence of vitamin D deficiency is high in subjects with HS.

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Section: Discussionsupporting

confidence: 90%

Bone Metabolism in Patients with Hidradenitis Suppurativa: A Case-control Study

et al. 2022

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“…In general, compared to control subjects, TBS was reported to be lower in patients with diabetes (42,(57)(58)(59), primary hyperparathyroidism (60)(61)(62)(63)(64), acromegaly (65)(66)(67)(68), anorexia nervosa (69,70), hypercortisolism (71)(72)(73), primary aldosteronism (especially in women) (74), with prolonged GC exposure (75)(76)(77)(78)(79)(80)(81)(82)(83)(84), rheumatoid arthritis and rheumatic disease (85)(86)(87), aromatase inhibition (88), kidney transplant recipients (89), as well as in patients on hemodialysis (90,91). In differentiated thyroid carcinomas, TBS was found to be lower in patients receiving long-term suppressive doses of thyroid-stimulating hormone than in patients receiving shorter-term therapy (92)(93)(94).…”

Section: Tbs and Fracture Risk Prediction In Patients With Diabetes A...mentioning

confidence: 99%

Update on trabecular bone score

Palomo¹,

Muszkat²,

Weiler³

et al. 2022

Archives of Endocrinology and Metabolism

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Trabecular bone score (TBS) is an indirect and noninvasive measure of bone quality. A low TBS indicates degraded bone microarchitecture, predicts osteoporotic fracture, and is partially independent of clinical risk factors and bone mineral density (BMD). There is substantial evidence supporting the use of TBS to assess vertebral, hip, and major osteoporotic fracture risk in postmenopausal women, as well as to assess hip and major osteoporotic fracture risk in men aged > 50 years. TBS complements BMD information and can be used to adjust the FRAX (Fracture Risk Assessment) score to improve risk stratification. While TBS should not be used to monitor antiresorptive therapy, it may be potentially useful for monitoring anabolic therapy. There is also a growing body of evidence indicating that TBS is particularly useful as an adjunct to BMD for fracture risk assessment in conditions associated with increased fracture risk, such as type-2 diabetes, chronic corticosteroid excess, and other conditions wherein BMD readings are often misleading. The interference of abdominal soft tissue thickness (STT) on TBS should also be considered when interpreting these findings because image noise can impact TBS evaluation. A new TBS software version based on an algorithm that accounts for STT rather than BMI seems to correct this technical limitation and is under development. In this paper, we review the current state of TBS, its technical aspects, and its evolving role in the assessment and management of several clinical conditions.

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“…Наибольший интерес вызывает применение ТКИ у пациентов с анкилозирующим спондилитом (АС), так как при этом заболевании хроническое воспаление приводит не только к потере трабекулярной, но и к селективной пролиферации кортикальной кости, что в позвоночнике проявляется в виде синдесмофитов, которые вместе с оссификацией связок ложно увеличивают значения МПК, полученные c помощью DXA [12]. По данным систематического обзора, частота низкой МПК у больных АС составляет 54% в L1-L4 и 51% в шейке бедра, при этом ОП встречается в этих областях в 16% и 13% случаев соответственно [8].…”

Section: анкилозирующий спондилитunclassified

“…В исследовательских целях для определения качества кости используют гистоморфометрический анализ биоптата подвздошной кости, а также дорогостоящие неинвазивные методы с высокой разрешающей способностью: периферическую количественную компьютерную томографию; отдельные виды объемной компьютерной томографии; магнитно-резонансную томографию. Эти методы обычно не доступны в первичном звене здравоохранения, поэтому постоянно ведутся поиски дополнительных способов оценки прочности кости и риска переломов, которые можно было бы использовать в клинической практике [12,13].…”

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Trabecular bone score in rheumatic disease

Kozyreva¹,

Nikitinskaya²,

Торопцова³

2022

Naučno-praktičeskaâ revmatologiâ

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Patients with rheumatic diseases (RD) are at high risk of osteoporosis (OP) and osteoporotic fractures. The Trabecular bone score (TBS) is a relatively novel method of assessing bone quality, which independently predicts fracture risk regardless of bone mineral density (BMD). A lower TBS in patients with RD compared to controls is shown in most studies concerning TBS and RD. The data obtained indicate that TBS predicts fractures better in RD, especially in patients receiving glucocorticoids, than BMD or the FRAX algorithm. TBS degradation has been associated with disease activity in ankylosing spondylitis, systemic sclerosis, and rheumatoid arthritis in a few studies. However, there is little data in the literature on the effect of rheumatic disease therapy and OP treatment in patients with RD on predictive ability of TBS for incident fracture.

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Trabecular Bone Score in Rheumatic Disease

Cited by 11 publications

References 48 publications

Bone Metabolism in Patients with Hidradenitis Suppurativa: A Case-control Study

Bone Metabolism in Patients with Hidradenitis Suppurativa: A Case-control Study

Update on trabecular bone score

Trabecular bone score in rheumatic disease

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