Trabecular bone score in healthy ageing

Bazzocchi, Alberto; Ponti, Federico; Diano, Danila; Amadori, Michele; Albisinni, Ugo; Battista, Giuseppe; Guglielmi, Giuseppe

doi:10.1259/bjr.20140865

Cited by 58 publications

(27 citation statements)

References 38 publications

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“…Our data are consistent with a recent study in a healthy Italian population across a wide age-spectrum that found no association between TBS and lean mass [40]. …”

Section: Discussionsupporting

confidence: 93%

Body composition predictors of skeletal integrity in obesity

et al. 2016

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Objective To determine body composition predictors of skeletal integrity in overweight/obese subjects using DXA. We hypothesized that visceral adiposity would be negatively, and lean mass positively, associated with DXA measures of skeletal integrity in obesity. Materials and Methods Our study was IRB approved and HIPAA compliant and written informed consent was obtained. We studied 82 overweight or obese but otherwise healthy premenopausal women and men of similar age who were part of a clinical trial (mean age: 37±10 years, mean BMI: 34±7kg/m2). All subjects underwent DXA of the spine and hip for assessment of bone mineral density (BMD), trabecular bone score (TBS), and hip structural analysis (HSA) and of the whole body for assessment of body composition, including estimated visceral adipose tissue (VAT). Results Sixty-three subjects (77%) had normal BMD and 19 subjects (23%) had osteopenia. There were strong age-, sex-, and BMD-independent positive associations between lean mass and HSA parameters (r=0.50 to r=0.81, p<0.0001), while there was no association with TBS. There were strong age-, sex- and BMD-independent inverse association between total fat and VAT mass and TBS (r= −0.60 and r=−0.72, p<0.0001 for both correlations), while there were no associations with HSA parameters. Conclusion Lean mass is a positive predictor of hip geometry while fat and VAT mass are negative predictors of trabecular microarchitecture in overweight/obese subjects.

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“…Our data are consistent with a recent study in a healthy Italian population across a wide age-spectrum that found no association between TBS and lean mass [40]. …”

Section: Discussionsupporting

confidence: 93%

Body composition predictors of skeletal integrity in obesity

et al. 2016

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“…The correlation between TBS and BMI does vary significantly by study. Kim and colleagues (18) reported a positive correlation 44( r =0.10) between TBS and BMI in a study of 1474 postmenopausal Korean women (Lunar DXA); Bazzocchi and colleagues (19) reported no correlation in a study of 250 Italian men and women (Lunar DXA); Sritara and colleagues (9) reported a weak negative correlation in a study of 848 Thai men and women (Hologic DXA); and Romagnoli and colleagues (20) reported a negative correlation in a study of 87 Italian men (Hologic DXA). Finally, McCloskey and colleagues (21) performed a large meta-analysis of studies of men and women of different ethnic origins (both Hologic and Lunar DXA), and reported an overall weaker negative correlation between TBS and BMI ( r =−0.16) than what we have found in the MrOS study population.…”

Section: Discussionmentioning

confidence: 98%

The Association Between Trabecular Bone Score and Lumbar Spine Volumetric BMD Is Attenuated Among Older Men With High Body Mass Index

Langsetmo

Ensrud

et al. 2016

Journal of Bone and Mineral Research

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Trabecular bone score (TBS) has been proposed as a dual-energy X-ray absorptiometry (DXA) derived measure of underlying quality of trabecular bone; however, TBS is not considered valid for those with body mass index (BMI) >37 kg/m2. Our objective was to determine the association between TBS and lumbar spine (trabecular) volumetric BMD (LS-VBMD) and to examine whether the association varied by BMI and body composition among older men below this clinical threshold. We used regression models to study 3479 men age ≥65 years enrolled in the Osteoporotic Fractures in Men (MrOS) study who had TBS from spine DXA scans, LS-VBMD from central quantitative computed tomography, measures of trunk fat and lean mass from DXA, and BMI <37kg/m2. TBS was categorized as normal (n = 925), partially degraded (n = 1747), and degraded (n = 807). TBS was inversely related to BMI, trunk fat mass, and trunk lean mass (all p< 0.001). The relationship between TBS and LS-VBMD was nonlinear with magnitude of effect (slope of regression line using standardized variables) ranging from 0.07 (95% CI, −0.02 to 0.15) among those with degraded TBS up to 0.71 (95% CI, 0.54 to 0.89) among those with normal TBS. The relationship was still nonlinear after adjusting for age, clinical site, and either BMI, trunk lean mass, or trunk fat mass. The magnitude of effect relating TBS and LS-VBMD also decreased with increasing BMI (interaction, p = 0.090) and increasing trunk lean mass (interaction, p = 0.001), but not with increasing trunk fat mass (interaction, p = 0.224). In summary, the strength of the association between TBS and LS-VBMD among older men was variable and dependent on BMI and body composition, particularly trunk lean mass. The clinical utility of TBS among older men may be somewhat limited among men with high BMI or high trunk lean mass.

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“…These deviations should be quantified, for example, in the form of (parametric or non-parametric) percentiles, similar to the Z-score or T-score of bone density. 26 However, no standard or reference values for body posture currently are published for healthy female subjects; reference values of the upper body posture for healthy men have been published only recently. 27 Also, classifications of the severity of posture deviations are only possible when deviations from standard or reference values are quantified.…”

Section: Introductionmentioning

confidence: 99%

Standard reference values of the upper body posture in healthy young female adults in Germany: an observational study

et al. 2018

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ObjectiveClassifications of posture deviations are only possible compared with standard values. However, standard values have been published for healthy male adults but not for female adults.DesignObservational study.SettingInstitute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe-University Frankfurt/Main.Participants106healthy female volunteers (21–30 years old; 25.1±2.7 years) were included. Their body weight ranged from 46 to 106 kg (60.3±7.9 kg), the heights from 1.53 to 1.82 m (1.69±0.06 m) and the body mass index from 16.9 kg/m² to 37.6 kg/m² (21.1±2.6 kg/m²).Outcome measuresA three-dimensional back scan was performed to measure the upper back posture in habitual standing. The tolerance ranges and CI were calculated. Group differences were tested by the Wilcoxon Mann-Whitney U test.ResultsIn normal posture, the spinal column was marginally twisted to the left, and the vertebrae were marginally rotated to the right. The kyphosis angle is larger than the lumbar angle. Consequently, a more kyphotic posture is observed in the sagittal plane. The habitual posture is slightly scoliotic with a rotational component (scapular depression right, right scapula marginally more dorsally, high state of pelvic right, iliac right further rotated anteriorly).ConclusionsHealthy young women have an almost ideally balanced posture with minimal ventral body inclination and a marginal scoliotic deviation. Compared with young males, women show only marginal differences in the upper body posture. These values allow a comparison to other studies, both for control and patient data, and may serve as guideline in both clinical practice and scientific studies.

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Trabecular bone score in healthy ageing

Abstract: The study reports TBS values of a selectively enrolled Italian healthy population, ranging from younger to older ages and including males as a reference standard. Moreover, links between body composition and TBS are explored.

Cited by 58 publications

References 38 publications

Body composition predictors of skeletal integrity in obesity

Body composition predictors of skeletal integrity in obesity

The Association Between Trabecular Bone Score and Lumbar Spine Volumetric BMD Is Attenuated Among Older Men With High Body Mass Index

Standard reference values of the upper body posture in healthy young female adults in Germany: an observational study

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