“…The advantages of TBS compared to the other proposed techniques mainly resides in the use of a non-invasive investigation, performed in the same place as the standard densitometric examination, without exposing the patient to additional radiations, with a (very) low burden on health care costs. The evaluation of TBS has been proposed, in association with dual-energy x-ray absorptiometry (DXA), for the study of bone quality in various endocrine disorders such as primary hyperaldosteronism, Cushing’s syndrome and subclinical hypercortisolism, primary hyperparathyroidism, GH deficiency, as well as diabetes mellitus, proving in some cases more reliable than BMD alone in identifying patients with a higher risk of fractures [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”