Trabecular Bone Score and Osteoporotic Fractures in Obese Postmenopausal Women

Ayoub, Marie-Louise; Maalouf, Ghassan; Cortet, Bernard; Legroux-Gérout, Isabelle; Zunquin, Gautier; Hage, Rawad El

doi:10.1016/j.jocd.2016.03.004

Cited by 8 publications

(3 citation statements)

References 12 publications

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“…For now, we do not have established cutoff points for the obtained TBS to classify as normal or abnormal results. The available TBS range has only been established for postmenopausal women ( 14 , 16 , 17 ). Only a few studies assessed the TBS values in acromegaly patients.…”

Section: Introductionmentioning

confidence: 99%

Trabecular Bone Score and Osteoprotegerin as Useful Tools in the Assessment of Bone Deterioration in Acromegaly

Jawiarczyk-Przybyłowska

Halupczok-Żyła

Syrycka

et al. 2022

Front. Endocrinol.

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PurposeThis study aimed to assess bone mineral density (BMD) and trabecular bone score (TBS) in 61 patients from the acromegaly group (AG) with regard to the activity of the disease in comparison to 42 patients—control group (CG). We also analyzed selected bone markers and their association with BMD and TBS.Materials and MethodsLumbar spine and femoral neck BMD measurements were performed. TBS values were obtained. Serum concentrations of selected bone markers, including osteoprotegerin (OPG), were measured.ResultsWe revealed a difference in TBS values between the AG and CG as well as between the TCA (treatment-controlled acromegaly) vs. CG and TCA+CA (cured acromegaly) vs. CG. We did not observe any statistically significant difference in BMD. OPG had a lower concentration in the CG compared to the AG. TBS correlated negatively with OPG in the AG (r = −0.31, p = 0.01) and in the TCA+ CA group (r = −0.3, p = 0.01).ConclusionsThe acromegalic patients have altered bone microstructure as indicated by the decreased TBS regardless of the activity of the disease and BMD. OPG could be a marker of the destruction of the bone microstructure, but further studies are needed.

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Section: Introductionmentioning

confidence: 99%

Trabecular Bone Score and Osteoprotegerin as Useful Tools in the Assessment of Bone Deterioration in Acromegaly

Jawiarczyk-Przybyłowska

Halupczok-Żyła

Syrycka

et al. 2022

Front. Endocrinol.

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“…Trabecular bone score cut-off points classifying normal and abnormal TBS values have not yet been defined. The only available TBS range is one that has been proposed for postmenopausal women [21][22][23].…”

Section: Tbs Evaluation Resultsmentioning

confidence: 99%

Trabecular bone score (TBS) as a noninvasive and complementary tool for clinical diagnosis of bone structure in endocrine disorders

Halupczok-Żyła

Bolanowski

2019

Endokrynologia Polska

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Trabecular bone score (TBS) index has recently been obtained as a result of textural greyscale analysis of DXA images. Because it enables the assessment of bone microarchitectural texture, TBS may be useful in evaluating bone quality. This study explores the current knowledge of the use of TBS in patients with endocrine disorders with co-occurring bone structure changes. Currently, the clinical importance TBS was verified in terms of disorders of the growth hormone/insulin-like growth factor 1 (GH/IGF-I) axis, glucocorticoid excess, thyroid and parathyroid disease, as well as in diabetes mellitus type 1 and 2. It has been clarified that patients suffering from various endocrinopathies are a group in which TBS should be used routinely because it correlates with clinical factors and may improve patient management in various endocrine disorders. (Endokrynol Pol 2019; 70 (4): 350-356)

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“…Lumbar spine BMD correlates positively with BMI, but BMD can be overestimated in obese people because of their central obesity [ 31 ]. However, in contrast to the relationship between BMD and BMI, one study reported a negative association between obesity and the TBS [ 32 ], although another study reported no association between BMI and TBS [ 33 ]. In the present study, TBS correlated negatively only in the group with BMI>25kg/m 2 , but not in the group with BMI<25 kg/m 2 .…”

Section: Discussionmentioning

confidence: 99%

Similarities and differences between bone quality parameters, trabecular bone score and femur geometry

Kim

2022

PLoS ONE

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Bone quality is a critical factor that, along with bone quantity, determines bone strength. Image-based parameters are used for assessing bone quality non-invasively. The trabecular bone score (TBS) is used to assess quality of trabecular bone and femur geometry for cortical bone. Little is known about the associations between these two bone quality parameters and whether they show differences in the relationships with age and body mass index (BMI). We investigated the associations between the trabecular bone score (TBS) and femur cortical geometry. Areal bone mineral density (BMD) was assessed using dual energy X-ray absorptiometry (DXA) and the TBS was assessed using iNsight software and, femur geometry using APEX (Hologic). A total of 452 men and 517 women aged 50 years and older with no medical history of a condition affecting bone metabolism were included. Z-scores for TBS and cortical thickness were calculated using the age-specific mean and SD for each parameter. A ‘discrepancy group’ was defined as patients whose absolute Z-score difference between TBS and cortical thickness was > 1 point. TBS and cortical thickness correlated negatively with age both in men and women, but the associations were stronger in women. Regarding the associations with BMI, TBS provided significant negative correlation with BMI in the range of BMI > 25 kg/m2. By contrast, cortical thickness correlated positively with BMI for all BMI ranges. These bone quality-related parameters, TBS and cortical thickness, significantly correlated, but discordance between these two parameters was observed in about one-third of the men and women (32.7% and 33.4%, respectively). Conclusively, image-based bone quality parameters for trabecular and cortical bone exhibit both similarities and differences in terms of their associations with age and BMI. These different profiles in TBS and FN cortical thickness might results in different risk profiles for the vertebral fractures or hip fractures in a certain percentage of people.

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Trabecular Bone Score and Osteoporotic Fractures in Obese Postmenopausal Women

Cited by 8 publications

References 12 publications

Trabecular Bone Score and Osteoprotegerin as Useful Tools in the Assessment of Bone Deterioration in Acromegaly

Trabecular Bone Score and Osteoprotegerin as Useful Tools in the Assessment of Bone Deterioration in Acromegaly

Trabecular bone score (TBS) as a noninvasive and complementary tool for clinical diagnosis of bone structure in endocrine disorders

Similarities and differences between bone quality parameters, trabecular bone score and femur geometry

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