Trabecular bone score and bone mineral density in patients with postsurgical hypoparathyroidism after total thyroidectomy for differentiated thyroid carcinoma

Iglesias, Sonsoles Guadalix; Dominguez, M.L.; Herrero, Eduardo Ferrero; Arroba, Cristina Martín-Arriscado; Díaz-Guerra, Guillermo Martínez; Carranza, Federico Hawkins

doi:10.1016/j.surg.2018.10.034

Cited by 9 publications

(8 citation statements)

References 19 publications

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“…A finding reported before in pediatric DTC survivors and adult DTC patients (especially in postmenopausal women). This could be explained by a lower bone turnover as a result of lower PTH values and, therefore, a reduced resorptive activity (17,(26)(27)(28). A second explanation could be found in the treatment of hypoparathyroidism with a PTHindependent stimulating effect of active vitamin D on osteoblasts.…”

Section: Discussionmentioning

confidence: 99%

Bone Mineral Density in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma: A Longitudinal Follow-Up Study

Dekker

Kobold

Brouwers

et al. 2021

Thyroid

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Background: Survivors of pediatric differentiated thyroid carcinoma (DTC) receive thyrotropin-suppressive therapy to minimize disease recurrence. However, knowledge about long-term effects of subclinical hyperthyroidism on bone mineral density (BMD) in pediatric DTC survivors is scarce, as is the information regarding long-term consequences of permanent hypoparathyroidism on BMD. We evaluated BMD in pediatric DTC survivors and investigated if BMD was affected by subclinical hyperthyroidism and/or permanent hypoparathyroidism during long-term follow-up. Methods: In this nationwide longitudinal study, we determined BMD in the lumbar spine and femur by dual energy X-ray absorptiometry in 65 pediatric DTC survivors. Measurements were repeated after minimal 5 years of follow-up in 46 pediatric DTC survivors. BMD results were evaluated according to the recommendations of the International Society for Clinical Densitometry (ISCD) and WHO. At both visits, we determined biochemical parameters and markers of bone resorption (C-terminal telopeptide of type I collagen [b-CTX]) and formation (N-propeptide of type I collagen [PINP] and osteocalcin). Results: First and second BMD measurements were done after a median follow-up of 17.0 (interquartile range [IQR] 8.0-25.0) and 23.5 (IQR 14.0-30.0) years after diagnosis, respectively. Median age at diagnosis was

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Section: Discussionmentioning

confidence: 99%

Bone Mineral Density in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma: A Longitudinal Follow-Up Study

Dekker

Kobold

Brouwers

et al. 2021

Thyroid

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“…As surgery is the primary treatment modality for PTC, the implications of treatment on vitamin D levels must be considered. Bone metabolism is one process which is heavily impacted by thyroidectomy and has potential implications on serum vitamin D. Hypoparathyroidism is common following thyroidectomy, with studies estimating anywhere from 19–38% incidence of transient injury and 3% of permanent deficiency following operative injury [ 43 ]. When studying post-menopausal women who underwent total thyroidectomy for differentiated thyroid cancer, those who underwent TSH suppression therapy with post-surgical hypoparathyroidism exhibited increased bone mineral density and decreased deterioration of bone microarchitecture when compared to their baseline parathyroid counterparts [ 43 ].…”

Section: Vitamin D and Papillary Thyroid Carcinomamentioning

confidence: 99%

“…Bone metabolism is one process which is heavily impacted by thyroidectomy and has potential implications on serum vitamin D. Hypoparathyroidism is common following thyroidectomy, with studies estimating anywhere from 19–38% incidence of transient injury and 3% of permanent deficiency following operative injury [ 43 ]. When studying post-menopausal women who underwent total thyroidectomy for differentiated thyroid cancer, those who underwent TSH suppression therapy with post-surgical hypoparathyroidism exhibited increased bone mineral density and decreased deterioration of bone microarchitecture when compared to their baseline parathyroid counterparts [ 43 ]. While some have proposed that pre-operative vitamin D levels play a role in predicting post-operative hypoparathyroidism, a recent study by Soáres et al found no relationship in a small prospective study [ 44 ].…”

Section: Vitamin D and Papillary Thyroid Carcinomamentioning

confidence: 99%

The Role of Vitamin D as a Prognostic Marker in Papillary Thyroid Cancer

Bains

Mur

Wallace

et al. 2021

Cancers

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The role of vitamin D in modulating several cancer-related pathways has received an increasing amount of attention in the past several years. Previous literature has found an abundance of evidence of vitamin D exerting an anti-proliferative, anti-inflammatory, and pro-differentiation effect in various types of cancers including breast, colon, prostate, and pancreatic cancer. Although the link between vitamin D and thyroid cancer remains controversial, both biochemical evidence and clinical studies have attempted to establish a link between papillary thyroid carcinoma (PTC) and vitamin D status. Furthermore, the use of vitamin D as a prognostic marker has received increased attention, both in regards to clinical outcomes and cancer staging. In this review, we briefly discuss the metabolism and proposed mechanism of action of vitamin D in the context of PTC, and explore links between modulators in the vitamin D pathway and progression of PTC. We provide evidence from both clinical studies as well as molecular studies of metabolic targets, including vitamin D receptor and activating enzymes exerting an effect on PTC tissue, which indicate that vitamin D may play a significant prognostic role in PTC.

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“…This index is more indicative of bone quantity and less indicative of bone quality. [19][20][21] Bone quality can predict osteoporosis and bone fractures better than the quantity of minerals inside the bone. The trabecular score examines the bone microstructure and mostly represents bone quality.…”

Section: Introductionmentioning

confidence: 99%

“…For this reason, two bones with similar density may have different strengths. 21,22 Loss of bone in osteoporosis is also associated with changes in the structure of the bone. The results of some studies have shown that this index can better indicate bone strength status.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Value-Added of the Trabecular Bone Score in Patients with Rheumatoid Arthritis

et al. 2021

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Background: Rheumatoid arthritis (RA) presents with inflammation in the joints and bony tissues around them. The trabecular bone score (TBS) is a relatively new indicator that predicts fracture risk better than bone mineral density (BMD). The aim of the current study was to measure TBSs and BMD of patients with RA referring to Resalat Hospital, Tehran. Methods: In this descriptive cross-sectional study, 129 men and women with RA entered the study through convenient sampling during 2016. TBS and BMD were measured in L1-L4. The relationships between age, sex, body mass index (BMI), duration of disease, and daily corticosteroids dose with TBS and BMD were determined by chi-square test, independent samples t test, Pearson correlation, and linear and logistic regression.

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Trabecular bone score and bone mineral density in patients with postsurgical hypoparathyroidism after total thyroidectomy for differentiated thyroid carcinoma

Cited by 9 publications

References 19 publications

Bone Mineral Density in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma: A Longitudinal Follow-Up Study

Bone Mineral Density in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma: A Longitudinal Follow-Up Study

The Role of Vitamin D as a Prognostic Marker in Papillary Thyroid Cancer

Evaluating the Value-Added of the Trabecular Bone Score in Patients with Rheumatoid Arthritis

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