Trabecular Bone Mineral Density in Idiopathic Scoliosis

Cook, Stephen D.; Harding, Amanda F.; Morgan, Eric Lease; Nicholson, Robert J.; Thomas, Kevin A.; Whitecloud, Thomas S.; Ratner, Evan S.

doi:10.1097/01241398-198703000-00011

Cited by 102 publications

(86 citation statements)

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“…Adolescent idiopathic scoliosis patients have been reported to have a low bone mass and osteopenia in both the axial and peripheral skeletons [6,8,11,13,35,38]. However, the precise mechanism of bone loss in AIS patients is unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Generalized low bone mass and osteopenia in both the axial and peripheral skeletons have been reported in AIS [7,8,11,13,35,38], and abnormal histomorphometric bone cell activity has been observed in AIS bone biopsies [9]. In addition, low bone mass is likely to persist through to adulthood in AIS patients [7], and there is increasing concern that adolescents with idiopathic scoliosis might have a lower peak bone mass, which would increase the risk of developing osteoporosis and related complications in later life [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Polymorphism in vitamin D receptor is associated with bone mineral density in patients with adolescent idiopathic scoliosis

2010

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Low bone mass and osteopenia have been reported in the axial and peripheral skeleton of adolescent idiopathic scoliosis (AIS) patients. Furthermore, several recent studies have shown that gene polymorphisms are related to osteoporosis. However, no study has yet linked polymorphisms in the vitamin D receptor (VDR) gene and bone mass in AIS. Accordingly, the authors examined the association between bone mass and VDR gene polymorphisms in 198 girls diagnosed with AIS. The VDR BsmI (rs1544410), FokI (rs2228670) and Cdx2 (rs11568820) polymorphisms and bone mineral density at the lumbar spine (LSBMD) and femoral neck (FNBMD) were analyzed and compared to their levels in healthy controls. Mean LSBMD and FNBMD in AIS patients were lower than in age-and sex-matched healthy controls (P = 0.0022 and P = 0.0013, respectively). A comparison of genotype frequencies in AIS patients and controls revealed a significant difference for the BsmI polymorphism only (P = 0.0054). Furthermore, a significant association was found between the VDR BsmI polymorphism and LSBMD. In particular, LSBMD in AIS patients with the AA genotype was found to be significantly lower than in patients with the GA (P \ 0.05) or GG (P \ 0.01) genotypes. However, no significant association was found between LSBMD or FNBMD and the VDR FokI or Cdx2 polymorphisms. These results suggest that the VDR BsmI polymorphism is associated with LSBMD in girls with AIS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polymorphism in vitamin D receptor is associated with bone mineral density in patients with adolescent idiopathic scoliosis

2010

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“…Whether osteoporosis in young scoliotics cause failure of spinal fusion postoperatively is to be proved. Burner et al [2] first raised the concern of osteopenia in AIS children using plain radiographs, but Cook et al [6] using DEXA showed that low bone mass was common in children of AIS. Thomas et al [22] found 50% of the children they followed up with scoliosis had osteoporosis, whereas Cheng and Guo [5] reported the prevalence of osteopenia to be 58.7% and osteoporosis of 18.7%.…”

Section: Discussionmentioning

confidence: 99%

Does scoliosis causes low bone mass? A comparative study between siblings

et al. 2008

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The aim of this study is to assess the prevalence low bone mass among girls with adolescent idiopathic scoliosis (AIS) and their siblings. The subjects of this study were Saudi Arabian girls with AIS. Patients had their weight and height measured to calculate their body mass index (BMI). Clinical examination and investigations were done to rule out any other cause of scoliosis. All had bone mineral density (BMD) measurement of hip area and the spine using DEXA scan, Hologic Inc. Patients with a BMD of \ -2.6 was taken as osteoporotic and those between \ -1 and -2.5 was taken as osteopenic for analysis. As control subjects, siblings of the patients with normal spine had their BMI calculated and BMD measurement done. We were able to analyze the data of 32 girls with an average age of 18.42 ± 5.71 (14-26) years with mean BMI of 17.7 ± 0.69 (16.5-18.5) kg/M 2 . Analysis of the scans of the hip revealed that 62.5% of the patients were osteoporotic with BMD of 0.837 (0.697-0.936) ± 0.04, T-score -3.8 ± 0.56 (-2.6 to -3.9) and Z-score. Nine (28.1%) were osteopenic with BMD of 0.768 ± 0.15 (0.638-0.878), mean T-score of -1.6 (-1.1 to 2.5) and Z-score -3.5 ± 0.63 (-2.9 to -3.9). Analysis of BMD of the spine showed similar results. In comparison to the scoliotics, girls with normal spine had higher BMI and BMD which was statistically significant at P \ 0.001. T-and Z-score was also lower in scoliotic girls in comparison with girls with normal spine significant at P \ 0.001 (CI 95%). Our study indicates that the scoliosis causes osteopenia and osteoporosis among girls while their siblings with normal spine remain with normal bone mass.

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“…Generalized reduced bone mass and osteopenia in both axial and peripheral skeletons have been reported in AIS [25][26][27]. Scoliosis causes osteopenia and osteoporosis among girls while their siblings with normal spine remain with normal bone mass [7].There is a decreased osteogenic differentiation of mesenchymal stem cell and reduced bone mineral density in AIS patients [28].…”

Section: Discussionmentioning

confidence: 99%

Fasting total ghrelin levels are increased in patients with adolescent idiopathic scoliosis

Gennero¹,

Conte-Auriol²,

Mus³

et al. 2013

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Background: A control study was designed to investigate circulating Ghrelin levels in adolescent girls with adolescent idiopathic scoliosis (AIS) and controls. Eating behavioral disorders, endocrine disorders, abnormal growth pattern and osteopenia have been well documented in AIS. Ghrelin is an orexigenic hormone produced by the stomach which reflects body weight changes and stimulates growth hormone secretion. Recently, it has been shown to be associated with bone metabolism and eating behavior. However, the circulating levels of ghrelin have never been evaluated in AIS patients. Methods: Forty nine AIS girls and 15 controls were included. Anthropometric parameters and fasting circulating total ghrelin were measured. Curve severity was evaluated in AIS girls. The relationships between ghrelin and age, body weight, height, body mass index (BMI), BMI Z-score and corrected anthropometric parameters were analyzed in AIS girls and controls. Results: There was no significant difference in body weight, height, BMI or BMI Z-score between AIS and controls. Serum ghrelin level was 1.8 fold higher in AIS girls than in controls. Elevation of ghrelin levels remained significant when corrected BMI or corrected BMI Z-score were considered. Unlike in controls, positive correlations were found between ghrelin and age in AIS girls with a gradual increase of circulating ghrelin with age. Conclusions: We have observed significantly higher circulating ghrelin levels in AIS than in controls with a positive correlation with age. This pilot-study suggests that ghrelin signaling might play a role in the initiation or development of AIS. Further studies are needed to validate theses results.

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Trabecular Bone Mineral Density in Idiopathic Scoliosis

Cited by 102 publications

References 0 publications

Polymorphism in vitamin D receptor is associated with bone mineral density in patients with adolescent idiopathic scoliosis

Polymorphism in vitamin D receptor is associated with bone mineral density in patients with adolescent idiopathic scoliosis

Does scoliosis causes low bone mass? A comparative study between siblings

Fasting total ghrelin levels are increased in patients with adolescent idiopathic scoliosis

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