Trabeculae type of juvenile aggressive ossifying fibroma of the maxilla: Report of two cases

Abstract

Juvenile ossifying fibroma (JOF) is a rare controversial fibroosseous lesion affecting the craniofacial skeleton and occurring commonly in children and young adults. It is highly aggressive and has a high tendency to recur. It is distinguished from the adult variant of ossifying fibroma on the basis of age, site, clinical behavior and microscopic appearance. Because of its high recurrence rate, which is 30–58%, complete excision is essential. Early diagnosis will circumvent the necessity of radical treatment. We report a rare case of trabecular JOF of maxilla where a computed tomography scan was taken to further support the characteristic feature of the lesion.

Resection of the incisive bone and rostral maxillae for removal of an ossifying fibroma in an 18‐year‐old Warmblood gelding

“…Oral fibromas are relatively common in young animals and human patients (Rai et al . ; Osunde et al . ) but rarely reported in the literature (Barber et al .…”

“…Therefore many tumours are presented at an advanced stage and treatment possibilities are more limited. Oral fibromas are relatively common in young animals and human patients (Rai et al 2012;Osunde et al 2013) but rarely reported in the literature (Barber et al 1983;Richardson et al 1991). These tumours are generally benign but may progress into invasive fibrosarcomas (Easley et al 2011).…”

Trabecular Variant of Juvenile Ossifying Fibroma (WHO Type) - A Rare Case Report and Review of the Literature

“…[10][11][12] Studies have shown that high levels of periodontal ligament activity and the constant irritation associated with both primary tooth exfoliation and permanent tooth eruption can contribute for the increased prevalence of reactive lesions in younger patients. [13] Rarely these lesions occur as a part of syndrome along with primary hyperparathyroidism designated as 'Hyperparathyroidism-Jaw tumor syndrome' (HPT-JT). [14] Genetic studies showed the presence of nonrandom chromosome break points at Xq26 and 2q33 resulting in (X; 2) translocation.…”

“…Malignant transformation rate was found to be 0.4 to 1%. [11,13] As JTOF shows aggressive behaviour, clinicians should be aware of the lesion with distinct histopathology, so that proper treatment can be planned to prevent recurrence in future.…”

“…[14] Genetic studies showed the presence of nonrandom chromosome break points at Xq26 and 2q33 resulting in (X; 2) translocation. [12][13][14] The recommended treatment is surgical excision. Recurrences in the range of 30 to 50% have been reported, mainly due to incomplete excision.…”