Trabectedin: Supportive care strategies and safety profile

Real-World Management of Trabectedin/Pegylated Liposomal Doxorubicin in Platinum-Sensitive Recurrent Ovarian Cancer Patients: A National Survey

“…31 On the other hand, gastroenterologists and hepatologists were rarely consulted (7.0% and 2.3% of specialists, respectively), thus confirming the relative low impact of liver toxicity in the routine experience. 32 Nonetheless, approximately half of responders surprisingly reported not to consider the consultation of other specialists relevant enough in order to increase patients' compliance to continue T/PLD treatment; this finding sounds really surprising, considering that the involvement of multidisciplinary teams is recognized to guarantee a more comprehensive approach to the adverse events of cytotoxic drugs. 33 On the other hand, the declared availability of most responders to participate to a retrospective collection of their own clinical data regarding T/PLD treatment of ROC patients could reveal that answering the survey in and by itself could have represented a way to test their own awareness of their usual approach and sensitize them to the issue.…”

Trabectedin for the treatment of soft tissue sarcomas

“…Moreover, preclinical and clinical data suggested that pretreatment with high doses of dexamethasone does not affect trabectedin efficacy but protects against trabectedininduced hepatic injury, possibly by decreasing hepatic exposure to trabectedin through the strong induction of the hepatic cytochrome P450 3A4 isoenzyme (43, 68,69). From these data derives the indication of a prophylactic premedication with dexamethasone (70) .…”

Metastatik Yumuşak Doku Sarkomlarında Trabektedin Kullanımının Retrospektif Değerlendirilmesi: Tek Merkez Deneyimi

“…Ayrıca premedikasyona ek olarak trabektedin tedavisi ile birlikte deksametazon kullanımının (4 mg/12 saat dozunda tedaviden 24 saat önce başlayıp, tedavi sonrası 2 gün verilmesi) hepatotoksisite ve diğer yan etkileri azalttığı görülmüştür, bu uygulama standart olarak tercih edilebilir. 12,13 Sarkomların miksoid liposarkom histolojik tipinde trabektedin tedavi yanıtının daha iyi olduğu ve metastazektominin sağkalım sonuçlarına pozitif katkısı olduğu bilinmektedir. Grosso F. ve ark.…”