TPX2 upregulates MMP13 to promote the progression of lipopolysaccharide-induced osteoarthritis
Jingtao Yu,
Weiqi Wang,
Zenghui Jiang
et al.
Abstract:Purpose
This study seeks to identify potential clinical biomarkers for osteoarthritis (OA) using bioinformatics and investigate OA mechanisms through cellular assays.
Methods
Differentially Expressed Genes (DEGs) from GSE52042 (four OA samples, four control samples) were screened and analyzed with protein-protein interaction (PPI) analysis. Overlapping genes in GSE52042 and GSE206848 (seven OA samples, and seven control samples) were identified and evaluated using Gene Set Enrichment Analysis (GSEA) and clin… Show more
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