Tpeak-Tend and Tpeak-Tend Dispersion as Risk Factors for Ventricular Tachycardia/Ventricular Fibrillation in Patients With the Brugada Syndrome

Hevia, Jesús Castro; Antzelevitch, Charles; Bárzaga, Francisco Tornés; Sánchez, Margarita Dorantes; Balea, Francisco Dorticós; Molina, Roberto Zayas; Pérez, Miguel Ángel Quiñones; Rodríguez, Yanela Fayad

doi:10.1016/j.jacc.2005.12.049

Cited by 451 publications

(369 citation statements)

References 36 publications

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“…However, due to the fact that the RT interval is shorter than the QT interval, its variability is much reduced and, more importantly, the information provided by RT variability and QTV has been shown to be different in certain populations, such as in patients with cardiovascular diseases [77]. In relation to this, recent studies in the literature have shown that the interval between the apex and end of the T wave possesses variability that is independent from HR and which can provide clinically useful information to be used for arrhythmic risk stratification [78]. The methodology described in [42] considers a linear parametric model to quantify the interactions between QTV and HRV, being applicable under steady-state conditions.…”

Section: ) Qt Adaptation To Hr Changesmentioning

confidence: 99%

Techniques for Ventricular Repolarization Instability Assessment From the ECG

2016

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Abstract-Instabilities in ventricular repolarization have been documented to be tightly linked to arrhythmia vulnerability. Translation of the information contained in the repolarization phase of the ECG into valuable clinical decision-making tools remains challenging. This work aims at providing an overview of the last advances in the proposal and quantification of ECG-derived indices that describe repolarization properties and whose alterations are related with threatening arrhythmogenic conditions. A review of the state-of-the-art is provided, spanning from the electrophysiological basis of ventricular repolarization to its characterization on the surface ECG through a set of temporal and spatial risk markers.Index Terms-Electrophysiological basis of the ECG, ECG waves, ECG intervals, repolarization instabilities, spatial and temporal ventricular repolarization dispersion, cardiac arrhythmias, biophysical modeling of the ECG, ECG signal processing, repolarization risk markers, T wave alternans, QT variability.

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Section: ) Qt Adaptation To Hr Changesmentioning

confidence: 99%

Techniques for Ventricular Repolarization Instability Assessment From the ECG

2016

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“…12) T peak -T end interval (T p-e ) is a well-known sensitive marker of spatial dispersion of ventricular repolarization. 13) A single observer manually measured T p-e of 5 consecutive beats, and the average was calculated. Clinical data: All 9 patients underwent echocardiography (Aplio XG ultrasonoscope, Toshiba Co., Tokyo) equipped with a 2.5-MHz transducer before starting the CR program.…”

Section: Methodsmentioning

confidence: 99%

Utility of Short-Term Variability of Repolarization as a Marker for Monitoring a Safe Exercise Training Program in Patients With Cardiac Diseases

et al. 2011

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SummaryIn order to begin searching for new markers for safe exercise training in patients with cardiac diseases, we tested the sensitivity and reliability of the short-term variability of repolarization (STV QT ) in comparison with QT interval, QTc, and T peak -T end interval (T p-e ) in patients with cardiac diseases.Nine patients (8 men, 1 woman; 58 ± 10 years) were enrolled. The cardiac rehabilitation (CR) program consisted of walking, bicycling on an ergometer, and calisthenics for 30-50 minutes/session and 3-5 sessions/week for 3 months. ECGs of 31 consecutive sinus beats were obtained before and after the CR program. RR and QT intervals were measured in the aV L lead. The mean orthogonal distance from the diagonal to the points of the Poincaré plots was determined using the following equation; STV QT [= Σ |QT n+1 -QT n /(30 × 2 1/2 )], as a marker of temporal dispersion of repolarization. Also, T p-e of 5 consecutive beats was measured as a marker of spatial dispersion.No fatal arrhythmias were observed in the CR. No significant difference was observed in the RR or QT interval between at baseline and at the end of the CR program. Meanwhile, QTc, STV QT and T p-e decreased significantly from 429 ± 27 to 400 ± 17 (P < 0.01), from 6.8 ± 1.3 to 4.7 ± 1.4 msec (P < 0.001), and from 74.8 (61.2/79.1) to 64.8 (51.4/70.7) msec (median (25th/75th percentile), P < 0.01), respectively.STV QT together with T p-e and QTc may reflect the time-courses of safe exercise training. (Int Heart J 2011; 52: 304-307)

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“…The Tp-e interval was defined as the interval from the peak of T wave to the end of T wave ( Figure I). Measurements of Tp-e interval were performed from precordial leads as it was described [13]. T-wave peak to end interval, QT and RR intervals were measured by a computer based method.…”

Section: Measurement Of Tp-e Qt and Qrs Intervals From The 12-lead Ecgmentioning

confidence: 99%

Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis

Ozluk¹,

Yılmaz²,

Topal³

et al. 2016

Eur Res J

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Objectives. Many systemic diseases including cardiovascular disturbances have been described in psoriatic patients. In the previous studies, left ventricle (LV) subclinical myocardial dysfunction was reported in the psoriasis patients. The T-wave peak to end (Tp-e) interval is a relatively new marker for ventricular arrhythmogenesis and repolarization heterogeneity. Prolongation of this interval represents a period of potential vulnerability to ventricular arrhythmias. However, there is no information available assessing the Tp-e interval and related calculations in patients with psoriasis disease. The aim of this study was to evaluate ventricular repolarization in patients with psoriasis disease by using QT, corrected QT (QTc) and Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio. Methods. In this study, retrospective analysis of 30 patients who underwent the psoriasis treatment and of 30 healthy individuals was performed. The severity of the disease was evaluated by the "Psoriasis Area and Severity Index". QT, corrected QT (QTc), Tp-e interval and Tp-e/QT ratio were measured by means of the 12-lead electrocardiogram. Left ventricular function was evaluated by echocardiography. Results. Baseline characteristics and QT and QTc intervals were similar in both groups. No difference was detected between the groups with regards to Tp-e interval (83.0±9 vs 82.3±10; p=0.81), Tpe/QT (0.22±0.03 vs 0.23±0.04; p=0.3) and p=0.77). Conclusions. These findings suggest that ventricular repolarization in mild to moderate psoriasis patients might be unimpaired. Larger samples and severe degree psoriasis patients are needed to evaluate the arrhythmia risk in psoriasis patients.Eur Res J 2016;2(1):46-51

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Tpeak-Tend and Tpeak-Tend Dispersion as Risk Factors for Ventricular Tachycardia/Ventricular Fibrillation in Patients With the Brugada Syndrome

Abstract: Our study demonstrates significant correlation between previous events, QTc >460 ms in V2, Tp-e, and Tp-e dispersion and occurrence of life-threatening arrhythmic events, suggesting that these parameters may be useful in risk stratification of patients with the Brugada syndrome.

Cited by 451 publications

References 36 publications

Techniques for Ventricular Repolarization Instability Assessment From the ECG

Techniques for Ventricular Repolarization Instability Assessment From the ECG

Utility of Short-Term Variability of Repolarization as a Marker for Monitoring a Safe Exercise Training Program in Patients With Cardiac Diseases

Evaluation of Tp-e interval and Tp-e/ QTc ratio in patients with mild to moderate psoriasis

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