TP63 links chromatin remodeling and enhancer reprogramming to epidermal differentiation and squamous cell carcinoma development

Man, Yi; Tan, Yixin; Wang, Li; Cai, Jing; Li, Xiaoling; Zeng, Zhaoyang; Wang, Xiong; Li, Guiyuan; Li, Xiayu; Tan, Pingqing; Xiang, Bo

doi:10.1007/s00018-020-03539-2

Cited by 46 publications

(40 citation statements)

References 195 publications

(244 reference statements)

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“…The American Cancer Society defines cancer stem celllike cells (CSCs) as a tumor cell type with self-renewal ability and multiple differentiation potential [29]; these form only a small part of tumor cells. Increasing researchers have indicated that differentiated tumor cells can regain stemness and become tumor stem cells through a process involving multiple mechanisms, including the indispensable effect of hypoxia on CSCs [30].…”

Section: Hypoxia Promotes Cancer Stem Cell Differentiation Into An Enmentioning

confidence: 99%

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

et al. 2021

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Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process found in many malignant tumors, and is different from the traditional angiogenetic process involving vascular endothelium. It involves the formation of microvascular channels composed of tumor cells; therefore, VM is considered a new model for the formation of new blood vessels in aggressive tumors, and can provide blood supply for tumor growth. Many studies have pointed out that in recent years, some clinical treatments against angiogenesis have not been satisfactory possibly due to the activation of VM. Although the mechanisms underlying VM have not been fully elucidated, increasing research on the soil “microenvironment” for tumor growth suggests that the initial hypoxic environment in solid tumors is inseparable from VM. Main body In this review, we describe that the stemness and differentiation potential of cancer stem cells are enhanced under hypoxic microenvironments, through hypoxia-induced epithelial-endothelial transition (EET) and extracellular matrix (ECM) remodeling to form the specific mechanism of vasculogenic mimicry; we also summarized some of the current drugs targeting VM through these processes, suggesting a new reference for the clinical treatment of tumor angiogenesis. Conclusion Overall, the use of VM inhibitors in combination with conventional anti-angiogenesis treatments is a promising strategy for improving the effectiveness of targeted angiogenesis treatments; further, considering the importance of hypoxia in tumor invasion and metastasis, drugs targeting the hypoxia signaling pathway seem to achieve good results.

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Section: Hypoxia Promotes Cancer Stem Cell Differentiation Into An Enmentioning

confidence: 99%

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

et al. 2021

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“…Head and neck squamous cell carcinoma (HNSCC) encompasses a group of malignant tumors originating from the squamous epithelium of the oral cavity, oropharynx, larynx, and hypopharynx [96][97][98]. Puram et al…”

Section: Highlighting Intra-and Inter-tumoral Heterogeneitymentioning

confidence: 99%

What are the applications of single-cell RNA sequencing in cancer research: a systematic review

Xiong

Wang

et al. 2021

J Exp Clin Cancer Res

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Single-cell RNA sequencing (scRNA-seq) is a tool for studying gene expression at the single-cell level that has been widely used due to its unprecedented high resolution. In the present review, we outline the preparation process and sequencing platforms for the scRNA-seq analysis of solid tumor specimens and discuss the main steps and methods used during data analysis, including quality control, batch-effect correction, normalization, cell cycle phase assignment, clustering, cell trajectory and pseudo-time reconstruction, differential expression analysis and gene set enrichment analysis, as well as gene regulatory network inference. Traditional bulk RNA sequencing does not address the heterogeneity within and between tumors, and since the development of the first scRNA-seq technique, this approach has been widely used in cancer research to better understand cancer cell biology and pathogenetic mechanisms. ScRNA-seq has been of great significance for the development of targeted therapy and immunotherapy. In the second part of this review, we focus on the application of scRNA-seq in solid tumors, and summarize the findings and achievements in tumor research afforded by its use. ScRNA-seq holds promise for improving our understanding of the molecular characteristics of cancer, and potentially contributing to improved diagnosis, prognosis, and therapeutics.

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“…In order to maintain the stability of the internal environment, normal cells actively and orderly trigger cell apoptosis through signal transduction mechanisms [95][96][97][98][99][100][101]. However, cancer cells can inhibit apoptosis by participating in these signaling pathways.…”

Section: N6-methyladenosine Can Influence the Apoptosisassociated Signaling Pathwaymentioning

confidence: 99%

N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies

Tan

Zhao

Xiong

et al. 2021

J Exp Clin Cancer Res

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The N6-methyladenosine (m6A) modification is a dynamic and reversible epigenetic modification, which is co-transcriptionally deposited by a methyltransferase complex, removed by a demethylase, and recognized by reader proteins. Mechanistically, m6A modification regulates the expression levels of mRNA and nocoding RNA by modulating the fate of modified RNA molecules, such as RNA splicing, nuclear transport, translation, and stability. Several studies have shown that m6A modification is dysregulated in the progression of multiple diseases, especially human tumors. We emphasized that the dysregulation of m6A modification affects different signal transduction pathways and involves in the biological processes underlying tumor cell proliferation, apoptosis, invasion and migration, and metabolic reprogramming, and discuss the effects on different cancer treatment.

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TP63 links chromatin remodeling and enhancer reprogramming to epidermal differentiation and squamous cell carcinoma development

Cited by 46 publications

References 195 publications

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

What are the applications of single-cell RNA sequencing in cancer research: a systematic review

N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies

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